VOLPE POMPEO

Contacts
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Structure Department of Biomedical Sciences
Telephone 0498276044
Qualification Professore associato confermato
Scientific sector MED/04 - GENERAL PATHOLOGY
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Office hours
Thursday from 13:00 to 15:00 Complesso Vallisneri, Dipartimento di Scienze Biomediche, I piano nord
(updated on 27/06/2013 13:22)

Curriculum Vitae
Pompeo Volpe earned his M.D. degree from the University of Padova Medical School (July 1979); postdoctoral Fellow (April 1980-March 1984) with Prof. A. Margreth (University of Padova, Italy), Prof. Sidney Fleischer (Vanderbilt University, Nashville, TN, USA), and Prof. Elizabeth W. Stephenson (New Jersey University of Medicine and Dentistry, Newark, NJ, USA); Investigator of the National Research Council, Center for Muscle Biology and Physiopathology, Padova (April 1984-December 1987); Associate Professor of Physiology and Biophysics, Department of Physiology and Biophysics, The University of Texas Medical Branch, Galveston, TX, USA (January 1988-June 1992); from November 1992, Associate Professor of general Pathology, Institute of general Pathology, University of Messina. Presently, Associate Professor of general Pathology, Department of Experimental Biomedical Sciences, University of Padova.
He has been referee for several scientific journals, and grant reviewer for the National Science Foundation, USA. He is member of the Biophysical Society, USA (1984), the Italian Society of Pathology (1985) and the American Physiological Society, USA (1989).
His research activity has been and is supported by funds obtained from: Italian Ministry of University, Telethon, Italian Space Agency, NIH.
He has published 132 articles in peer-reviewed journals and 17 articles in books or Meeting reports. He has been invited to give 73 lectures and seminars at Italian and foreign Universities, and international meetings.
He is in the list of Top Italian Scientists formulated by the VIA-Academy with a an H-index of 43.

Publications
125. J. Qin, G. Valle, A. Nani, A. Nori, S.G Priori, P. Volpe and M. Fill. Luminal Ca2+ Regulation of Single Cardiac Ryanodine Receptor Channels: Insights provided by calsequestrin and its mutants. J. Gen. Physiol. 131: 325-334, 2008.

126. D. Terentyev, Z. Kubalova, G. Valle, A. Nori, S. Vedamoorthyrao, R. Terentyeva, S. Viatchenko-Karpinski, D.M. Bers, S.C. Williams, P. Volpe and S. Gyorke. Modulation of SR Ca release by luminal Ca and calsequestrin in cardiac myocytes: Effects of CASQ mutations Linked to Sudden Cardiac Death. Biophys. J. 95: 2037-2048, 2008.

127. G. Valle, D. Galla, A. Nori, S.G. Priori, S. Gyorke, V. De Filippis and P. Volpe. CPVT-related mutations R33Q and L167H alter calcium sensitivity of human cardiac calsequestrin. Biochem. J. 413: 291-303, 2008.

128. N. Rizzi, N. Liu, C. Napolitano, A. Nori, F. Turcato, B. Colombi, S. Bicciato, D. Arcelli, A. Spedito, M. Scelsi, L. Villani, G. Esposito, S. Boncompagni, F. Protasi, P. Volpe and S.G. Priori. Unexpected structural and functional consequences of the R33Q homozygous mutation in cardiac calsequestrin. A complex arrhythmogenic cascade in a knock in mouse model. Circ. Res. 103: 298-306, 2008.

130. J. Qin, G. Valle, A. Nani, H. Chen, J. Franco-Ramos, A. Nori, P. Volpe and M. Fill. Ryanodine receptor luminal calcium regulation: swapping calsequestrin and channel isoforms. Biophys. J. 97: 1961-1970, 2009.

131. M. Salanova, E. Bortoloso, G. Schiffl, M. Gutsmann, D. L. Belavý, D. Felsenberg, S. Furlan, P. Volpe and D. Blottner. Expression and regulation of Homer in human skeletal muscle during neuromuscular junction adaptation to disuse and exercise. FASEB J. 25: 4312-4325, 2011.

132. M. Tomasi, M. Canato, C. Paolini, M. Dainese, C. Reggiani, P. Volpe, F. Protasi and A. Nori. Calsequestrin (CASQ1) rescues function and structure of calcium release units in skeletal muscles of CASQ1-null mice. Am. J. Physiol. Cell Physiol. 302: C575-C586, 2012.

133. M. Denegri, J.E.E. Cruz, S. Boncompagni, S. De Simone, A. Auricchio, L. Villani, P. Volpe, F. Protasi, C. Napolitano and S.G. Priori. Viral gene transfer rescues arrhythmogenic phenotype and ultrastructural abnormalities in adult Calsequestrin-null mice with inherited arrhythmias. Circ. Res. 110: 663-668, 2012.

134. E. Bortoloso, A. Megighian, S. Furlan, L. Gorza and P. Volpe. Homer 2 antagonizes protein degradation in slow-twitch skeletal muscles. Am. J. Physiol. Cell Physiol. 304: C68-C77, 2013.

135. C. Chiarello, E. Bortoloso, A. Carpi, S. Furlan and P. Volpe. Negative feedback regulation of Homer 1a on norepinephrine-dependent cardiac hypertrophy. Exp. Cell Res., 2013, in press.

136. L. Brunello, J.L. Slabaugh, P.B Radwanski, H.-T. Ho, A.E. Belevych, Q. Lou, H. Chen, C. Napolitano, F. Lodola, S.G. Priori, V. Fedorov, P. Volpe, M. Fill, P.M. Janssen and S. Györke. Synchronization of proarrhythmic Ca2+ signaling in cardiac muscle harboring a calsequestrin 2 mutation linked to Catecholaminergic Polymorphic Ventricular Tachycardia. Proc. Natl. Acad. Sci., 2013, in press.

137. H. Chen, G. Valle, S. Furlan, A. Nani, S. Gyorke, M. Fill and P. Volpe. Mechanism of Calsequestrin Regulation of Single Cardiac Ryanodine Receptor in normal and pathological conditions. J. Gen. Physiol., 2013, in press.

138. C. Manno, L Figueroa, L. Royer, S. Pouvreau, C.-S. Lee, P. Volpe, A. Nori, J. Zhou, G. Meissner, S, L. Hamilton and E. Ríos. Altered Ca2+ concentration, permeability and buffering power in the myofiber Ca2+ store of a mouse model of malignant hyperthermia. J. Physiol., 2013, in press.

List of taught course units in A.Y. 2019/20
Degree course code (?) Degree course track Course unit code Course unit name Credits Year Period Lang. Teacher in charge
FA1732 COMMON FAM1027344 10 3rd Year (2019/20) First
semester
ITA POMPEO VOLPE