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Structure Department of Surgery, Oncology and Gastroenterology
Qualification Ricercatore a tempo determinato di tipo B
Scientific sector MED/04 - GENERAL PATHOLOGY
University telephone book  Show

Office hours
Monday from 14:00 to 15:00 Please notify Prof. Pasqual by email if you would like to meet her during the student dedicated time, or if you would like to schedule a meeting in another time slot.
(updated on 22/01/2020 12:50)

Curriculum Vitae

Lecturer's Curriculum (PDF): F97D753CA7B1C6B722F4A3C913F0889E.pdf

Research areas
Interactions between different cell types are key for immune function. Nevertheless, our toolbox to observe and decipher the biological meaning of interactions between immune cells in living animals is very limited. By coupling chemical and synthetic biology with mouse genetics, research in my lab aims at developing innovative technologies to study cell-cell communication in the immune system. We use these novel experimental approaches to track interactions between antigen-presenting cells and T cells, with the ultimate goal of revealing the molecular pathways governing the T cell response in vivo.

• Chudnovskiy A, Pasqual G, Victora GD (2019) Studying interactions between dendritic cells and T cells in vivo. Current Opinion in Immunology, 58:24-30.

• Pasqual G, Chudnovskiy A, Tas JM, Schweitzer LD, Cui A, Agudelo M, Hacohen N, Victora GD (2018) Monitoring T cell–dendritic cell interactions in vivo by intercellular enzymatic labeling. Nature, 553:496-500.

• Ersching J, Efeyan A, Mesin L, Jacobsen JT, Pasqual G, Grabiner BC, Dominguez-Sola D, Sabatini DM, Victora GD (2017) Germinal center selection and affinity maturation require dynamic regulation of mTORC1. Immunity 46:1045-1058.

• Tas JM#, Mesin L#, Pasqual G, Targ S, Jacobsen JT, Mano YM, Chen CS, Weill JC, Reynaud CA, Browne EP, Meyer-Hermann M, Victora GD (2016) Visualizing affinity maturation in germinal centers. Science 351:1048-54. #equal contribution

• Pasqual G, Angelini A, Victora GD (2015) Triggering positive selection of germinal center B cells by antigen targeting to DEC-205. Methods in Molecular Biology 1291:125-34.

• Shulman Z, Gitlin AD, Targ S, Jankovic M, Pasqual G, Nussenzweig MC, Victora GD (2013) T follicular helper cell dynamics in germinal centers. Science 341:673-7.

• Pythoud C, Rodrigo WW, Pasqual G, Rothenberger S, Martinez-Sorbido L, de la Torre JC, Kunz S (2012) Arenavirus nucleoprotein targets interferon regulatory factor-activating kinase IKKε. Journal of Virology 86:7728-38.

• Burri DJ, Pasqual G, Rochat C, Seidah NG, Pasquato A, Kunz S (2012) Molecular characterization of the processing of arenavirus envelope glycoprotein precursors by subtilisin kexin isozyme-1/site-1 protease. Journal of Virology 86:4935-46.

• Pasquato A, Rochat C, Burri DJ, Pasqual G, de la Torre JC, Kunz S (2012) Evaluation of the anti-arenaviral activity of the subtilisin kexin isozyme-1/site-1 protease inhibitor PF-429242 in acute and persistent infection. Virology 423:14-22.

• Pasqual G, Rojek JM, Masin M, Chatton JY, Kunz S (2011) Old World arenaviruses enter the host cell via the multivesicular body and depend on the endosomal sorting complex required for transport. PLoS Pathogens 7:e1002232.

• Pasqual G, Burri DJ, Pasquato A, de la Torre JC, Kunz S (2011) Role of the host cell's unfolded protein response in arenavirus infection. Journal of Virology 85:1662-70.

• Rojek JM, Pasqual G, Sanchez AB, Nguyen NT, de la Torre JC, Kunz S (2010) Targeting the proteolytic processing of the viral glycoprotein precursor is a promising novel antiviral strategy against arenaviruses. Journal of Virology 84:573-84.

List of taught course units in A.Y. 2019/20
Degree course code (?) Degree course track Course unit code Course unit name Credits Year Period Lang. Teacher in charge
ME1727 COMMON ME14103788 6 2nd Year (2019/20) Second