CHILIN ADRIANA

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Structure Department of Pharmaceutical and Pharmacological Sciences
Telephone 0498275349
Qualification Professore associato confermato
Scientific sector CHIM/08 - PHARMACEUTICAL CHEMISTRY
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Office hours
Dipartimento di Scienze del Farmaco Ricevo tutti i giorni (tranne in orario di lezione) previo appuntamento (via mail all'indirizzo adriana.chilin@unipd.it)
(updated on 11/01/2019 09:57)

Proposals for thesis
- Progettazione, sintesi e studio di inibitori ATP-mimetici di tirosinchinasi. Preparazione tramite sintesi convenzionali o MAOS. Definizione di modelli QSAR per la progettazione razionale di nuovi inibitori.
- Progettazione, sintesi e studio di modulatori di CFTR per la terapia della fibrosi cistica. Preparazione tramite sintesi convenzionali o MAOS.
- Progettazione, sintesi e studio di inibitori di NF-kB a struttura furocumarinilacetica e propionica.
- Progettazione, sintesi e studio di inibitori di HDAC e ibridi molecolari.

Curriculum Vitae
Adriana Chilin

1983 - Honours Degree in Pharmaceutical Chemistry and Technology (UniPD)
1984 - Research Fellow at R&D ChemLab - GLAXO - Verona
1985 - 1988 PhD fellow at Dept of Pharmaceutical Sciences (UniPD)
1988 - PhD in Pharmaceutical Sciences (UniPD)
1989 - 2000 Assistant Professor (UniPD)
2000 - today Associate Professor of Medicinal Chemistry (UniPD)

Chair of the Degree Course Teachers' Council in Pharmacy (UniPD)
Coordinator of Teaching Committee (DSF UniPD)
Member of Dept Board (DSF UniPD)
Member of Teaching Committee in School of Medicine (UniPD)
Member of Teachers' Council in "Scuola di Specializzazione in Farmacia Ospedaliera" (UniPD)
Member of Teacher's Council of PhD course in Molecular Sciences UniPD
From 2008 to 2010 President of Veneto Section of Italian Chemical Society.

Teaching activities
Medicinal Chemistry 1 for the master degree in Pharmacy.
Principles of Medicinal Chemistry for the degree in Biotechnology
Laboratory of Synthesis and Extraction of Drugs for the Degree in Pharmaceutical Chemistry and Technology.

AREAS OF EXPERTISE
Organic synthesis and Microwave Assisted Organic Synthesis (expecially in the field of furocoumarins and quinazoline derivatives), Flash Chromatography, HPLC, IR Spectroscopy, 1D and 2D NMR Spectroscopy, Mass Spectrometry, Rationalization of drug-target interactions through QSAR and molecular modelling

Last ten years research topics
1. Design, synthesis and biological evaluation of 1) NF-kB inhibitors, 2) CFTR correctors and potentiators, 3) topoisomerase inhibitors.
2. Design, synthesis and biological evaluation of ATP-mimetic tyrosine kinase inhibitors.

Coordinator of research projects funded by MIUR, Università di Padova, FFC (Fondazione per la fibrosi cistica)
Member of scientific societies (ACS American Chemical Society; SCI Società Chimica Italiana)
Author of 88 international full papers, 1 PCT and 3 national patents.
Peer reviewer of many international Chemistry and medicinal chemistry journals.


Research areas
Design, synthesis and biological evaluation of furocoumarin derivatives as corrector/potentiator of CFTR for the treatmente of Cystic fibrosis
Polyheterocycles with direct or photomediated antiproliferative activity. Preparation by conventional synthetic methodologies and/or microwave assisted synthesis (MAOS). Evaluation of the antiproliferative activity of the compounds mediated by DNA interactions (in the dark and under UV light) and by replicative enzymes.
Coumarin and quinolinone derivatives. Preparation by conventional synthesis and/or MAOS. Evaluation of the antiproliferative activity of the compounds mediated by protein kinase CK2.
New potential topoisomerase I and II inhibitors with heterocyclic structures. Rational design through molecular docking studies and synthesis by conventional techniques and/or MAOS. Evaluation of the antiproliferative and antitopoisomerase activity.
Quinazoline-based compounds as ATP-mimetic tyrosine kinase inhibitors. Setting up of new strategies for the synthesis of quinazoline nucleus and of 4-anilinoquinazoline derivatives by conventional and MAOS techniques. Evaluation of the biological activity profile of the compounds. Refinement of QSAR models for rational design of tyrosine kinase inhibitors.
Non-peptidomimetic proteasome inhibitors with psoralenquinone structure. Synthesis and evaluation of the inhibitory potency on the catalytic activity and study of the selectivity profile of the compounds. Rationalization of the activity and selectivity profiles through molecular docking studies.
NF-kB inhibitors with furocoumarinylacetic or propionic structure. Refinement and setting up of novel synthetic strategies by means of MAOS.
Synthesis of endocannabinoid-like compounds and evaluation of their biological activity.
Identification of organic compounds through 1H-NMR and 13C-NMR spectroscopy and Mass spectrometry.

Publications
See the attached file for the full list of pubblications

Last 10 Papers

1. G. Marzaro, I. Lampronti, E. D’Aversa, G. Sacchetti, G. Miolo, C. Vaccarin, G. Cabrini, MC. Dechecchi, R. Gambari, A. Chilin. Design, Synthesis and Biological Evaluation of Novel Trimethylangelicin Analogues Targeting Nuclear Factor κB (NF-κB). Eur. J. Med. Chem., 151, 285-293 (2018), DOI:10.1016/j.ejmech.2018.03.080
2. I. Lampronti, MG. Manzione, G. Sacchetti, D. Ferrari, S. Spisani, V. Bezzerri, A. Finotti, M. Borgatti, MC. Dechecchi, G. Miolo, G. Marzaro, G. Cabrini, R. Gambari, A. Chilin. Differential Effects of Angelicin Analogues on NF-κB Activity and IL-8 Gene Expression in Cystic Fibrosis IB3-1 Cells, Mediators of Inflammation, DOI:10.1155/2017/238948.
3. Mologni L, Dalla Via M, Chilin A, Palumbo M, Marzaro G. Discovery of novel wtRET and V804MRET inhibitors: from hit to lead. ChemMedChem. 2017 doi:10.1002/cmdc.201700243.
4. Milani, R; Brognara, E; Fabbri, E; Finotti, A; Borgatti, M; Lampronti, I; Marzaro, G; Chilin, A; Lee, Kk; Kok, Sh; Chui, Ch; Gambari, R. Corilagin Induces High Levels of Apoptosis in the Temozolomide-Resistant T98G Glioma Cell Line. Oncology research, 2017 DOI:10.3727/096504017X14928634401187
5. Di Giovanni, C; Novellino, E; Chilin, A; Lavecchia, A; Marzaro, G. Investigational drugs targeting cyclin-dependent kinases for the treatment of cancer: an update on recent findings (2013-2016). Expert Opinion On Investigational Drugs 25, 1215-1230 (2016). doi:10.1080/13543784.2016.1234603.
6. G. Marzaro, L. Dalla Via, A.N. García-Argáez, M. Dalla Via, A. Chilin. Novel benzoquinoline derivatives via unpredicted condensation of ethyl propiolate and naphthylamines: Synthesis and topoisomerase inhibition activity. Bioorganic & Medicinal Chemistry Letters - 26, 4875-4878 (2016). DOI:10.1016/j.bmcl.2016.09.031
7. G. Marzaro, I. Castagliuolo, G. Schirato, G. Palu', M. Dalla Via, A. Chilin, P. Brun*. Substituted quinazolinones as kinase inhibitors endowed with anti-fibrotic properties, Eur. J. Med. Chem., 115, 416-425 (2016), DOI:10.1016/j.ejmech.2016.03.053
8. Bianchi, Nicoletta; Cosenza, Lucia Carmela; Lampronti, Ilaria; Finotti, Alessia; Breveglieri, Giulia; Zuccato, Cristina; Fabbri, Enrica; Marzaro, Giovanni; Chilin, Adriana; De Angelis, Gioia; Borgatti, Monica; Gallucci, Cristiano; Alfieri, Cecilia; Ribersani, Michela; Isgrò, Antonella; Marziali, Marco; Gaziev, Javid; Morrone, Aldo; Sodani, Pietro; Lucarelli, Guido; Gambari, Roberto; Paciaroni, Katia. Structural and Functional Insights on an Uncharacterized Aγ-Globin-Gene Polymorphism Present in Four β(0)-Thalassemia Families with High Fetal Hemoglobin Levels, Mol. Diagn. Ther., 20, 161-173 (2016). DOI:10.1007/s40291-016-0187-2
9. V. Gandin, A. Ferrarese, M. Dalla Via, C. Marzano, A. Chilin, G. Marzaro. Targeting kinases with anilinopyrimidines: discovery of N-phenyl-N'-[4-(pyrimidin-4-ylamino)phenyl]urea derivatives as selective inhibitors of class III receptor tyrosine kinase subfamily. Sci. Rep. 5, 16750 (2015). DOI:10.1038/srep16750
10. L. Dalla Via, G. Marzaro, A. Mazzoli, A. Chilin, G. Miolo. Photobiological properties of 3-psoralenacetic acids. Photochem. Photobiol. Sci., 14, 2074-86 (2015). DOI:10.1039/c5pp00210a

Lecturer's Publications (PDF): F3956EDA370BDD9EF965D89E28C548A2.pdf

List of taught course units in A.Y. 2019/20
Degree course code (?) Degree course track Course unit code Course unit name Credits Year Period Lang. Teacher in charge
FA1732 COMMON FA04101259 10 3rd Year (2019/20) Second
semester
ITA ADRIANA CHILIN
IF1839 COMMON FA01106705 7 3rd Year (2019/20) First
semester
ITA ADRIANA CHILIN


Responsibility of other activity for A.Y. 2019/20
Degree course code (?) Degree course track Course unit code Course unit name Credits Year Period Lang. Teacher in charge
FA1732 COMMON FAL1006436 15 5th Year (2019/20) Annual ITA ADRIANA CHILIN
FA1732 COMMON FAL1002660 30 5th Year (2019/20) Annual ITA ADRIANA CHILIN
FA1732 COMMON FAO2043860 1 4th Year (2019/20) Annual ITA ADRIANA CHILIN
FA1732 COMMON FAO2043870 1 4th Year (2019/20) Annual ITA ADRIANA CHILIN
FA1732 COMMON FAO2043874 1 4th Year (2019/20) Annual ITA ADRIANA CHILIN
FA1732 COMMON FAL1006435 15 4th Year (2019/20) Second
semester
ITA ADRIANA CHILIN
FA1732 COMMON FAO2043874 1 2nd Year (2019/20) Annual ITA ADRIANA CHILIN