CALISTRI ARIANNA

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Structure Department of Molecular Medicine
Telephone 0498272341
Qualification Professore associato confermato
Scientific sector BIO/19 - GENERAL MICROBIOLOGY
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Office hours
Ogni giorno previo appuntamento via e-mail: arianna.calistri@unipd.it
(updated on 20/04/2017 11:51)

Proposals for thesis
- Sviluppo di vettori lentivirali per approcci di terapia genica di malattia infettive, neurodegenerative e tumori

- Ingegnerizzazione del virus dell'herpes simplex di tipo 1 per il trattamento di tumori solidi

- Studio delle interazione tra proteine virali e proteine cellulari coinvolte nelle fasi finali del ciclo replicativo di herpesvirus e lentivirus

Curriculum Vitae
EDUCATION
1992 Diploma di maturita’ classica, Liceo Ginnasio C Marchesi, Padova, Italy
1997 Laurea in Scienze Biologiche obtained with best marks and honours (110/110 cum laude), University of Padova, Italy, discussing a thesis: “A new in vitro model of herpes simplex virus type 1 (HSV-1) persistent infection: interactions between HSV-1 and human immunodeficiency virus type 1 (HIV-1)”.
1998 Member of the college of Biologists of Italy after passing the National board examination
2002 Ph.D. in Microbiological Science, University of Genova, Italy.

RESEARCH EXPERIENCE AND POSITIONS
1994-1997 Research fellow, University of Padova, Italy
1997-2001 Ph.D. student, University of Padova, Italy
1999-2000 Visiting researcher, Dana Farber Cancer Institute, Department of Pathology, Harvard Medical School, Boston, MA
2001-2004 Postdoctoral fellow, Dana Farber Cancer Institute, Department of Pathology, Harvard Medical School, Boston, MA
2004-2005 Postdoctoral fellow, Department of Histology Microbiology and Medical Biotechnologies, University of Padova, Italy
01/01/2005-31/08/2015 Assistant Professor of Microbiology and Clinical Microbiology (SSD MED/07), Department of Molecular Medicine, University of Padova, Italy
03/2012- 12/2013 Seconded National Expert for HIV-1/AIDS and chronic diseases at the General Directorate SANCO, Unit C4 ("Health determinants"), at the European Commission, Luxembourg
01/09/2015- Associate Professor of Microbiology (SSD BIO/19), Department of Molecular Medicine, University of Padova, Italy

AWARDS AND HONORS
1996 Winner of a Scolarship for spending a period of time at a foreign laboratory ("C.A. Iannella Scholarship Foundation", Boston, MA).
2000 Winner of a fellowship for AIDS research (Borsa AIDS, Istituto Superiore di Sanità, Italy)
2001 Winner of the “3M Pharmaceuticals HSV Research Travel Scholarship”, in association with the International Herpes Management Forum.
2001 Winner of a fellowship for AIDS research (Borsa AIDS Istituto Superiore di Sanità, Italy)
2003 Winner of the GlaxoSmithKline Elion Award for Young Investigator, in association with the International Herpes Management Forum.
2011 Winner of the Italian Society for Virology special prize: "Virology in the 21st Century". Awarder by Prof. Adriano Aguzzi Institute of Neuropathology, University Hospital of Zurich; Prof. Pier Luigi Gambetti, Institute of Pathology, Case Western Reserve University School of Medicine, Cleveland, USA; Prof. Volker ter Meulen, Institut für Virologie und Immunobiologie Universität Wuerzburg, Germany; Prof. Sir John James Skehel National Institute for Medical Research Mill Hill, London

MAIN RESEARCH CONTRIBUTIONS
Arianna Calistri is author of 63 publications in peer reviewed journals with an H-index of 20(Scopus June 2019).

AFFILIATIONS
Member of the Società Italiana di Microbiologia Generale e Biotecnologie Microbiche (SIMGBM) since 2004, Member of the Società Italiana di Virologia (SIV) (2001-2016) – Vicepresident of the SIV (2012-2016). Member of the European Society for Virology since 2009, Member of the Advisory Board (April 2019-today). Founding Member and Member of the Advisory Council of the Società Italiana di Virologia – Italian Society for Virology (SIV-ISV) since October 2016.

Research areas
Studi sull’interazione a livello cellulare e molecolare fra HIV-1 e patogeni opportunisti. In particolare viene HHV8) sulla capacità di HIV-1 di infettare specifici tipi cellulari;

Studio dell’interazione fra proteine virali e cellulari implicate in diverse fasi del ciclo replicativo di retrovirus ed herpesvirus, in particolare la gemmazione e la risposta della cellula all'infezione;

Studi di neurovirulenza nel modello murino in seguito ad infezione con herpes simplex di tipo 1;

Studi di sieroprevalenza delle infezioni erpetiche in Italia (in collaborazione con diversi gruppi di ricerca italiani e con l’industria farmaceutica);

Messa a punto di nuovi sistemi diagnostici e analisi molecolare del virus dell'influenza umana e aviaria;

Utilizzo dei virus come tool di terapia genica di malattie infettive e neurodegenerative.

Publications
1. CALISTRI A, PAROLIN C, PIZZATO M, CALVI P, GIARETTA I, PALU’ G. Herpes simplex virus chronically infected human T lymphocytes are susceptible to HIV-1 superinfection and support HIV-1 pseudotyping. JAIDS-J. Acq. Imm. Def. 1999; 21: 90-98.
2. STRACK B, CALISTRI A*, ACCOLA M, PALU’ G, GOTTLINGER H. A role for ubiquitin ligase recruitment in retrovirus release. Proc. Natl. Acad. Sci. USA. 2000; 97:13063-13068. *Co-first authorship.
3. STRACK B, CALISTRI A, GÖTTLINGER H. Late assembly domain function can exhibit context dependence and involves ubiquitin residues implicated in endocytosis. J. Virol. 2002; 76:5472-5479.
4. CALISTRI A, PAROLIN C, PALU' G. Herpes simplex virus type 1 either enhances or suppresses human immunodeficiency virus type 1 replication in human CD4 lymphocytes. J. Med. Virol. 2003; 70:163-170.
5. STRACK B, CALISTRI A, CRAIG S, POPOVA E, GÖTTLINGER H. AIP1/ALIX is a binding partner for HIV-1 p6 and EIAV p9 functioning in virus budding. Cell. 2003; 114: 689-699.
6. SARINELLA F, CALISTRI A, SETTE P, PALU’ G, PAROLIN C. Oncolysis of pancreatic tumour cells by a γ 34.5 deleted HSV-1 does not rely upon Ras-activation, but on the PI 3-kinase pathway. Gene Ther. 2006;13:1080-1087.
7. PIZZATO M, HELANDER A, POPOVA E, CALISTRI A, ZAMBORLINI A, PALU’ G, GÖTTLINGER HG. Dynamin 2 is required for the enhancement of HIV-1 infectivity by Nef. Proc. Natl. Acad. Sci. USA. 2007;104:6812-6817.
8. CALISTRI A, SETTE P, SALATA C, CANCELLOTTI E, FORGHIERI C, COMIN A, GÖTTLINGER H, CAMPADELLI-FIUME G, PALU’ G, PAROLIN C. Intracellular trafficking and maturation of herpes simplex virus type 1 gB and virus egress require functional biogenesis of multivesicular bodies. J. Virol. 2007; 81:11468-11478.
9. CALISTRI A, DEL VECCHIO C, CELESTINO M, CELEGATO M, GOTTLINGER H, PALU’ G, PAROLIN C. Role of the feline immunodeficiency virus l-domain in the presence or absence of gag processing: involvement of ubiquitin and nedd4-2s ligase in viral egress. J. Cell. Physiol. 2009; 218:175-182.
10. CALISTRI A, SALATA C, PAROLIN C, PALU’ G. Role of multivesicular bodies and their components in the egress of enveloped RNA viruses. Rev. Med. Virol. 2009; 19:31-45.
11. CALISTRI A, SALATA C, COSENTINO M, ASNICAR S, FRANCHIN E, CUSINATO R, PACENTI M, DONATELLI I, PALU’ G. Report of two cases of influenza virus A/H1N1v and B co-infection during the 2010/2011 epidemics in the Italian Veneto Region. Virol. J. 2011; 8:502.
12. CELESTINO M, CALISTRI A, DEL VECCHIO C, SALATA C, CHIUPPESI F, PISTELLO M, BORSETTI A, PALU’ G, PAROLIN C. Feline tetherin is characterized by a short N-terminal region and is counteracted by the feline immunodeficiency virus envelope glycoprotein. J Virol. 2012; 86:6688-6700.
14. CALISTRI A, MUNEGATO D, TOFFOLETTO M, CELESTINO M, FRANCHIN E, COMIN A, SARTORI E, SALATA C, PAROLIN C, PALU’ G. Functional interaction between the ESCRT-I component TSG101 and the HSV-1 tegument ubiquitin specific protease. J Cell Physiol. 2015; 230:1794-1806.
15. SPANEVELLO F*, CALISTRI A*, PARISI SP, DEL VECCHIO C, MANTELLI B, FRASSON C, BASSO G, PALU’ G, CAVAZZANA M, PAROLIN C. Development of lentiviral vectors simultaneously expressing multiple siRNAs against CCR5, vif and tat/rev genes for an HIV-1 gene therapy approach. Mol Ther Nucleic Acids. 2016 Apr 19;5:e312.

Lecturer's Publications (PDF): F26B867CF35CCE751C013FC979868514.pdf

List of taught course units in A.Y. 2019/20
Degree course code (?) Degree course track Course unit code Course unit name Credits Year Period Lang. Teacher in charge
SC1177 COMMON SCL1000651 8 2nd Year (2019/20) First
semester
ITA FEDERICO RASTRELLI
IF1839 COMMON SCO2045384 12 2nd Year (2019/20) Second
semester
ITA ARIANNA CALISTRI