CALISTRI ARIANNA

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Structure Department of Molecular Medicine
Telephone 0498272341
Qualification Professore associato confermato
Scientific sector BIO/19 - GENERAL MICROBIOLOGY
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Office hours
Ogni giorno previo appuntamento via e-mail: arianna.calistri@unipd.it
(updated on 20/04/2017 11:51)

Proposals for thesis
- Sviluppo di vettori lentivirali per approcci di terapia genica di malattia infettive, neurodegenerative e tumori

- Ingegnerizzazione del virus dell'herpes simplex di tipo 1 per il trattamento di tumori solidi

- Studio delle interazione tra proteine virali e proteine cellulari coinvolte nelle fasi finali del ciclo replicativo di herpesvirus e lentivirus

Curriculum Vitae
Arianna Calistri, Associate Professor of Microbiology, Department of Molecular Medicine, University of Padova – Italy. DATE OF BIRTH: 22nd of June 1973;
EDUCATION: 1992 Diploma di maturita’ classica, Liceo Ginnasio C Marchesi, Padova, Italy; 1997 Laurea in Scienze Biologiche obtained with best marks and honours (110/110 cum laude), University of Padova, Italy; 2002 Ph.D. in Microbiological Science, University of Genova, Italy.
RESEARCH EXPERIENCE: 1994-1997 Research fellow, University of Padova, Italy; 1997-2001 Ph.D. student, University of Padova, Italy; 1999-2000 Visiting researcher, Department of Pathology, Harvard Medical School, Boston, MA; 2001-2004 Postdoctoral fellow, Department of Pathology, Harvard Medical School, Boston, MA; 2004-2005 Postdoctoral fellow, Department of Histology Microbiology and Medical Biotechnologies, University of Padova, Italy; 2005-2015 Assistant Professor, Department of Molecular Medicine, University of Padova, Italy; 2015- today Associate Professor, Department of Molecular Medicine, University of Padova, Italy.
AWARDS AND HONORS: 1996 Winner of a Scolarship for spending a period of time at a foreign laboratory ("C.A. Iannella Scholarship Foundation", Boston, MA); 2001 Winner of the “3M Pharmaceuticals HSV Research Travel Scholarship”, in association with the International Herpes Management Forum; 2003 Winner of the GlaxoSmithKline Elion Award for Young Investigator, in association with the International Herpes Management Forum; 2011 Winner of the Italian Society for Virology special prize “Virology in the 21st century”. This prize was intended to award a young Italian virologist (under 40 years of age) who carried out intense experimental research in Italy or other Countries.
RESEARCH CONTRIBUTIONS: Arianna Calistri is author of 55 publications in peer review Journals with a total IF of 233.727, 1487 (Scopus) H-index of 16 (Scopus). The main lines of research developed so far are: - the study of the viral/cellular protein interactions involved in specific phases of viral life cycle and pathogenesis. The viral families taken into consideration are Herpesviridae, Retroviridae and Orthomyxoviridae; -the translation of basic research on a more specific and effective manipulation of viruses to be employed as therapeutic tools or transgene delivery systems; -the development of new diagnostic tools based on molecular biology techniques to improve the correct management of patients affected by viral infections, with a special focus on influenza virus.

Research areas
Studi sull’interazione a livello cellulare e molecolare fra HIV-1 e patogeni opportunisti. In particolare viene HHV8) sulla capacità di HIV-1 di infettare specifici tipi cellulari;

Studio dell’interazione fra proteine virali e cellulari implicate in diverse fasi del ciclo replicativo di retrovirus ed herpesvirus, in particolare la gemmazione e la risposta della cellula all'infezione;

Studi di neurovirulenza nel modello murino in seguito ad infezione con herpes simplex di tipo 1;

Studi di sieroprevalenza delle infezioni erpetiche in Italia (in collaborazione con diversi gruppi di ricerca italiani e con l’industria farmaceutica);

Messa a punto di nuovi sistemi diagnostici e analisi molecolare del virus dell'influenza umana e aviaria;

Utilizzo dei virus come tool di terapia genica di malattie infettive e neurodegenerative.

Publications
1. CALISTRI A, PAROLIN C, PIZZATO M, CALVI P, GIARETTA I, PALU’ G. Herpes simplex virus chronically infected human T lymphocytes are susceptible to HIV-1 superinfection and support HIV-1 pseudotyping. JAIDS-J. Acq. Imm. Def. 1999; 21: 90-98.
2. STRACK B, CALISTRI A*, ACCOLA M, PALU’ G, GOTTLINGER H. A role for ubiquitin ligase recruitment in retrovirus release. Proc. Natl. Acad. Sci. USA. 2000; 97:13063-13068. *Co-first authorship.
3. STRACK B, CALISTRI A, GÖTTLINGER H. Late assembly domain function can exhibit context dependence and involves ubiquitin residues implicated in endocytosis. J. Virol. 2002; 76:5472-5479.
4. CALISTRI A, PAROLIN C, PALU' G. Herpes simplex virus type 1 either enhances or suppresses human immunodeficiency virus type 1 replication in human CD4 lymphocytes. J. Med. Virol. 2003; 70:163-170.
5. STRACK B, CALISTRI A, CRAIG S, POPOVA E, GÖTTLINGER H. AIP1/ALIX is a binding partner for HIV-1 p6 and EIAV p9 functioning in virus budding. Cell. 2003; 114: 689-699.
6. SARINELLA F, CALISTRI A, SETTE P, PALU’ G, PAROLIN C. Oncolysis of pancreatic tumour cells by a γ 34.5 deleted HSV-1 does not rely upon Ras-activation, but on the PI 3-kinase pathway. Gene Ther. 2006;13:1080-1087.
7. PIZZATO M, HELANDER A, POPOVA E, CALISTRI A, ZAMBORLINI A, PALU’ G, GÖTTLINGER HG. Dynamin 2 is required for the enhancement of HIV-1 infectivity by Nef. Proc. Natl. Acad. Sci. USA. 2007;104:6812-6817.
8. CALISTRI A, SETTE P, SALATA C, CANCELLOTTI E, FORGHIERI C, COMIN A, GÖTTLINGER H, CAMPADELLI-FIUME G, PALU’ G, PAROLIN C. Intracellular trafficking and maturation of herpes simplex virus type 1 gB and virus egress require functional biogenesis of multivesicular bodies. J. Virol. 2007; 81:11468-11478.
9. CALISTRI A, DEL VECCHIO C, CELESTINO M, CELEGATO M, GOTTLINGER H, PALU’ G, PAROLIN C. Role of the feline immunodeficiency virus l-domain in the presence or absence of gag processing: involvement of ubiquitin and nedd4-2s ligase in viral egress. J. Cell. Physiol. 2009; 218:175-182.
10. CALISTRI A, SALATA C, PAROLIN C, PALU’ G. Role of multivesicular bodies and their components in the egress of enveloped RNA viruses. Rev. Med. Virol. 2009; 19:31-45.
11. CALISTRI A, SALATA C, COSENTINO M, ASNICAR S, FRANCHIN E, CUSINATO R, PACENTI M, DONATELLI I, PALU’ G. Report of two cases of influenza virus A/H1N1v and B co-infection during the 2010/2011 epidemics in the Italian Veneto Region. Virol. J. 2011; 8:502.
12. CELESTINO M, CALISTRI A, DEL VECCHIO C, SALATA C, CHIUPPESI F, PISTELLO M, BORSETTI A, PALU’ G, PAROLIN C. Feline tetherin is characterized by a short N-terminal region and is counteracted by the feline immunodeficiency virus envelope glycoprotein. J Virol. 2012; 86:6688-6700.
14. CALISTRI A, MUNEGATO D, TOFFOLETTO M, CELESTINO M, FRANCHIN E, COMIN A, SARTORI E, SALATA C, PAROLIN C, PALU’ G. Functional interaction between the ESCRT-I component TSG101 and the HSV-1 tegument ubiquitin specific protease. J Cell Physiol. 2015; 230:1794-1806.
15. SPANEVELLO F*, CALISTRI A*, PARISI SP, DEL VECCHIO C, MANTELLI B, FRASSON C, BASSO G, PALU’ G, CAVAZZANA M, PAROLIN C. Development of lentiviral vectors simultaneously expressing multiple siRNAs against CCR5, vif and tat/rev genes for an HIV-1 gene therapy approach. Mol Ther Nucleic Acids. 2016 Apr 19;5:e312.

List of taught course units in A.Y. 2018/19
Degree course code (?) Degree course track Course unit code Course unit name Credits Year Period Lang. Teacher in charge
IF1839 COMMON SCO2045384 12 2nd Year Second
semester
ITA ARIANNA CALISTRI