CALISTRI ARIANNA

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Structure Department of Molecular Medicine
Telephone 0498272341
Qualification Professore associato confermato
Scientific sector BIO/19 - GENERAL MICROBIOLOGY
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Office hours
Ogni giorno previo appuntamento via e-mail: arianna.calistri@unipd.it
(updated on 20/04/2017 11:51)

Proposals for thesis
- Sviluppo di vettori lentivirali per approcci di terapia genica di malattia infettive, neurodegenerative e tumori

- Ingegnerizzazione del virus dell'herpes simplex di tipo 1 per il trattamento di tumori solidi

- Studio delle interazione tra proteine virali e proteine cellulari coinvolte nelle fasi finali del ciclo replicativo di herpesvirus e lentivirus

Curriculum Vitae
Arianna Calistri, Associate Professor of Microbiology, Department of Molecular Medicine, University of Padova – Italy. DATE OF BIRTH: 22nd of June 1973;
EDUCATION: 1992 Diploma di maturita’ classica, Liceo Ginnasio C Marchesi, Padova, Italy; 1997 Laurea in Scienze Biologiche obtained with best marks and honours (110/110 cum laude), University of Padova, Italy; 2002 Ph.D. in Microbiological Science, University of Genova, Italy.
RESEARCH EXPERIENCE: 1994-1997 Research fellow, University of Padova, Italy; 1997-2001 Ph.D. student, University of Padova, Italy; 1999-2000 Visiting researcher, Department of Pathology, Harvard Medical School, Boston, MA; 2001-2004 Postdoctoral fellow, Department of Pathology, Harvard Medical School, Boston, MA; 2004-2005 Postdoctoral fellow, Department of Histology Microbiology and Medical Biotechnologies, University of Padova, Italy; 2005-2015 Assistant Professor, Department of Molecular Medicine, University of Padova, Italy; 2015- today Associate Professor, Department of Molecular Medicine, University of Padova, Italy.
AWARDS AND HONORS: 1996 Winner of a Scolarship for spending a period of time at a foreign laboratory ("C.A. Iannella Scholarship Foundation", Boston, MA); 2001 Winner of the “3M Pharmaceuticals HSV Research Travel Scholarship”, in association with the International Herpes Management Forum; 2003 Winner of the GlaxoSmithKline Elion Award for Young Investigator, in association with the International Herpes Management Forum; 2011 Winner of the Italian Society for Virology special prize “Virology in the 21st century”. This prize was intended to award a young Italian virologist (under 40 years of age) who carried out intense experimental research in Italy or other Countries.
RESEARCH CONTRIBUTIONS: Arianna Calistri is author of 55 publications in peer review Journals with a total IF of 233.727, 1487 (Scopus) H-index of 16 (Scopus). The main lines of research developed so far are: - the study of the viral/cellular protein interactions involved in specific phases of viral life cycle and pathogenesis. The viral families taken into consideration are Herpesviridae, Retroviridae and Orthomyxoviridae; -the translation of basic research on a more specific and effective manipulation of viruses to be employed as therapeutic tools or transgene delivery systems; -the development of new diagnostic tools based on molecular biology techniques to improve the correct management of patients affected by viral infections, with a special focus on influenza virus.

Research areas
Studi sull’interazione a livello cellulare e molecolare fra HIV-1 e patogeni opportunisti. In particolare viene HHV8) sulla capacità di HIV-1 di infettare specifici tipi cellulari;

Studio dell’interazione fra proteine virali e cellulari implicate in diverse fasi del ciclo replicativo di retrovirus ed herpesvirus, in particolare la gemmazione e la risposta della cellula all'infezione;

Studi di neurovirulenza nel modello murino in seguito ad infezione con herpes simplex di tipo 1;

Studi di sieroprevalenza delle infezioni erpetiche in Italia (in collaborazione con diversi gruppi di ricerca italiani e con l’industria farmaceutica);

Messa a punto di nuovi sistemi diagnostici e analisi molecolare del virus dell'influenza umana e aviaria;

Utilizzo dei virus come tool di terapia genica di malattie infettive e neurodegenerative.

Publications
1. CALISTRI A, PAROLIN C, PIZZATO M, CALVI P, GIARETTA I, PALU’ G. Herpes simplex virus chronically infected human T lymphocytes are susceptible to HIV-1 superinfection and support HIV-1 pseudotyping. JAIDS-J. Acq. Imm. Def. 1999; 21: 90-98.
2. STRACK B, CALISTRI A*, ACCOLA M, PALU’ G, GOTTLINGER H. A role for ubiquitin ligase recruitment in retrovirus release. Proc. Natl. Acad. Sci. USA. 2000; 97:13063-13068. *Co-first authorship.
3. STRACK B, CALISTRI A, GÖTTLINGER H. Late assembly domain function can exhibit context dependence and involves ubiquitin residues implicated in endocytosis. J. Virol. 2002; 76:5472-5479.
4. CALISTRI A, PAROLIN C, PALU' G. Herpes simplex virus type 1 either enhances or suppresses human immunodeficiency virus type 1 replication in human CD4 lymphocytes. J. Med. Virol. 2003; 70:163-170.
5. STRACK B, CALISTRI A, CRAIG S, POPOVA E, GÖTTLINGER H. AIP1/ALIX is a binding partner for HIV-1 p6 and EIAV p9 functioning in virus budding. Cell. 2003; 114: 689-699.
6. SARINELLA F, CALISTRI A, SETTE P, PALU’ G, PAROLIN C. Oncolysis of pancreatic tumour cells by a γ 34.5 deleted HSV-1 does not rely upon Ras-activation, but on the PI 3-kinase pathway. Gene Ther. 2006;13:1080-1087.
7. PIZZATO M, HELANDER A, POPOVA E, CALISTRI A, ZAMBORLINI A, PALU’ G, GÖTTLINGER HG. Dynamin 2 is required for the enhancement of HIV-1 infectivity by Nef. Proc. Natl. Acad. Sci. USA. 2007;104:6812-6817.
8. CALISTRI A, SETTE P, SALATA C, CANCELLOTTI E, FORGHIERI C, COMIN A, GÖTTLINGER H, CAMPADELLI-FIUME G, PALU’ G, PAROLIN C. Intracellular trafficking and maturation of herpes simplex virus type 1 gB and virus egress require functional biogenesis of multivesicular bodies. J. Virol. 2007; 81:11468-11478.
9. CALISTRI A, DEL VECCHIO C, CELESTINO M, CELEGATO M, GOTTLINGER H, PALU’ G, PAROLIN C. Role of the feline immunodeficiency virus l-domain in the presence or absence of gag processing: involvement of ubiquitin and nedd4-2s ligase in viral egress. J. Cell. Physiol. 2009; 218:175-182.
10. CALISTRI A, SALATA C, PAROLIN C, PALU’ G. Role of multivesicular bodies and their components in the egress of enveloped RNA viruses. Rev. Med. Virol. 2009; 19:31-45.
11. CALISTRI A, SALATA C, COSENTINO M, ASNICAR S, FRANCHIN E, CUSINATO R, PACENTI M, DONATELLI I, PALU’ G. Report of two cases of influenza virus A/H1N1v and B co-infection during the 2010/2011 epidemics in the Italian Veneto Region. Virol. J. 2011; 8:502.
12. CELESTINO M, CALISTRI A, DEL VECCHIO C, SALATA C, CHIUPPESI F, PISTELLO M, BORSETTI A, PALU’ G, PAROLIN C. Feline tetherin is characterized by a short N-terminal region and is counteracted by the feline immunodeficiency virus envelope glycoprotein. J Virol. 2012; 86:6688-6700.
14. CALISTRI A, MUNEGATO D, TOFFOLETTO M, CELESTINO M, FRANCHIN E, COMIN A, SARTORI E, SALATA C, PAROLIN C, PALU’ G. Functional interaction between the ESCRT-I component TSG101 and the HSV-1 tegument ubiquitin specific protease. J Cell Physiol. 2015; 230:1794-1806.
15. SPANEVELLO F*, CALISTRI A*, PARISI SP, DEL VECCHIO C, MANTELLI B, FRASSON C, BASSO G, PALU’ G, CAVAZZANA M, PAROLIN C. Development of lentiviral vectors simultaneously expressing multiple siRNAs against CCR5, vif and tat/rev genes for an HIV-1 gene therapy approach. Mol Ther Nucleic Acids. 2016 Apr 19;5:e312.

List of taught course units in A.Y. 2019/20
Degree course code (?) Degree course track Course unit code Course unit name Credits Year Period Lang. Teacher in charge
SC1177 COMMON SCL1000651 8 2nd Year First
semester
ITA FEDERICO RASTRELLI
IF1839 COMMON SCO2045384 12 2nd Year Second
semester
ITA ARIANNA CALISTRI