LAVEDER PAOLO

Contacts
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Structure Department of Biology
Telephone 0498276368
Qualification Ricercatore universitario confermato
Scientific sector BIO/18 - GENETICS
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Office hours
Complesso Biologico "A. Vallisneri", sesto piano est (CRIBI), stanza 87. Tutti i giorni dalle 15.30 alle 16.30, previo appuntamento per e-mail.
(updated on 25/06/2018 20:07)

Proposals for thesis
Human response to hypobaric hypoxia: genetic factors. The research is part of a larger study (european project Resamont2), aimed at the clinical, instrumental and genetic evaluation of high altitude diseases. TECHNIQUES: microarray expression profiling, bioinformatics analyses, real-time qRT-PCR focused on HIF (Hypoxia Inducible Factors) target genes.

Curriculum Vitae
Degree in Biological Sciences (1990), PhD in Biochemistry and Biophysics ( 1994). Post-Doc at the Max Perutz Laboratories (Vienna, Austria) in the Department of Microbiology and Genetics (1994-98). Assistant Professor (Vertragassistent) of the Vienna University in 1997-98. As fellow of Telethon Italy I have been involved for years (1998-2003) in strategic projects aimed to discovery and functional characterization of genes specifically expressed in skeletal muscle. In particular, I had been following construction of the Mouse MuscleArray, a novel non-redundant collection of cDNA probes for microarray studies (GEO Accession Number: GPL1523). My expertise in systematic sequencing of muscle EST, led me to expression profiling of human and mouse skeletal muscle affected by muscular dystrophies and other disorders. From 2006 until today: Assistant Professor (Ricercatore) at the Department of Biology, University of Padua.
My current scientific interest is in the field of functional genomics, with particular focus on molecular mechanisms regulating muscle plasticity. I am also involved in the european project Resamont2, aimed at the clinical, instrumental and genetic evaluation of high altitude diseases.
Teaching activity: Courses of Genetic Engineering (since 2002), Genomics (2006-2009), Transcriptomics (2009-2010). Laboratory instructor for several courses, both in Vienna and in Padua. Since 2012 mentor for biology in the italian team participating at the European Union Science Olympiad (EUSO). Responsible at the University of Padua for the MIUR project "Piano Nazionale Lauree Scientifiche", Biology and Biotechnology in the years 2015 – 2018.
Member of the European Society for Muscle Research (ESMR); author of 15 in extenso papers with average IF 5.16


Research areas
My current scientific interest is in the field of functional genomics, with particular focus on molecular mechanisms regulating muscle plasticity. I am also involved in the european project Resamont2, aimed at the clinical, instrumental and genetic evaluation of high altitude diseases.

Publications
Frangini M, Franzolin E, Chemello F, Laveder P, Romualdi C, Bianchi V, Rampazzo C.
Synthesis of mitochondrial DNA precursors during myogenesis, an analysis in purified C2C12 myotubes.
J Biol Chem. 288(8):5624-35 (2013).

Chemello F, Bean C, Cancellara P, Laveder P, Reggiani C, Lanfranchi G.
Microgenomic analysis in skeletal muscle: expression signatures of individual fast and slow myofibers.
PLoS One. 6(2):e16807 (2011).

Millino C, Fanin M, Vettori A, Laveder P, Mostacciuolo ML, Angelini C, Lanfranchi G.
Different atrophy-hypertrophy transcription pathways in muscles affected by severe and mild spinal muscular atrophy.
BMC Medicine 7 :14 (2009).

Feltrin E et al,
Muscle Research and Gene Ontology: New standards for improved data integration.
BMC Med Genomics. 2(1):6 (2009).

Cagnin S et al,
Reconstruction and functional analysis of altered molecular pathways in human atherosclerotic arteries.
BMC Genomics 10(1):13 (2009).

Calura E, Cagnin S, Raffaello A, Laveder P, Lanfranchi G, Romualdi C.
Meta-analysis of expression signatures of muscle atrophy: gene interaction networks in early and late stages.
BMC Genomics 9(1):630 (2008).

Raffaello A., Laveder P., Romualdi C., Bean C., Toniolo L., Germinario E. Megighian A., Danieli-Betto D., Reggiani C. and Lanfranchi G.
Denervation in Murine Fast-Twitch Muscle: Short Term Physiological Changes and Temporal Expression Profiling.
Physiological Genomics 25 (1): 60-74 (2006).

Toppo, S., Cannata, N., Fontana P., Romualdi, C., Laveder, P., Bertocco, E., Lanfranchi, G. and Valle, G.
TRAIT (TRAnscript Integrated Table): a knowledgebase of human skeletal muscle transcripts
Bioinformatics 19 (5): 661-662 (2003).

Campanaro S et al,
Gene expression profiling in dysferlinopathies using a dedicated muscle microarray
Human Molecular Genetics 11 (26): 3283-3298 (2002).

Laveder P, De Pittà C, Toppo S, Valle G and Lanfranchi G.
A two-step strategy for constructing specifically self-subtracted cDNA libraries.
Nucleic Acids Research 30 (9): e38 (2002).

Faulkner G et al,
FATZ, a filamin-, actinin-, and telethonin-binding protein of the Z-disc of skeletal muscle.
J. Biol. Chem. 275 (52): 41234-42 (2000).

Laveder P, Schmidt WM., Schnabl S, Schweyen RJ. and Mueller, M.W.
Retrotransposition by complete reverse splicing of catalytic group II intron RNA into genomic DNA.
YEAST, vol. 13, p. 120 (1997).

Nicoletti L, Laveder P, Pellizzari R, Cardazzo B and Carignani G.
Comparative analysis of the region of the mitochondrial genome containing the ATPase subunit 9 gene in the two related yeast species Saccharomyces douglasii and Saccharomyces cerevisiae
Curr Genet 25 (6): 504-7 (1994).

Lanfranchi G, Pallavicini A, Laveder P and Valle G.
Ancestral hemoglobin switching in lampreys
Dev Biol 164 (2): 402-8 (1994).

Laveder P, Bergantino E, Carignani G
The protein encoded by a group ll intron is associated with the mitochondrial ribonucleoprotein particles (RNPs) in S. cerevisiae.
YEAST, vol. 8, p. 424 (1992).

Nicoletti L et al,
Sequences analysis of regions coding for the protein biosynthetic apparatus in the mitochondrial genome of S. douglasii.
YEAST, vol. 8, p. 432 (1992).

Lanfranchi G, Odorizzi S, Laveder P and Valle G.
Different globin messenger RNAs are present before and after the metamorphosis in Lampetra zanandreai
Dev Biol 45 (2): 367-73 (1991).

List of taught course units in A.Y. 2019/20
Degree course code (?) Degree course track Course unit code Course unit name Credits Year Period Lang. Teacher in charge
IF1839 COMMON SCO2045392 10 2nd Year (2019/20) Second
semester
ITA CLAUDIA DEL VECCHIO