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Structure Department of Biology
Telephone 0498276343
Qualification Professore associato confermato
Scientific sector BIO/10 - BIOCHEMISTRY
University telephone book  Show

Office hours
Monday from 10:00 to 11:00 Complesso Vallisneri - Viale G. Colombo, 3 - 6° PIANO NORD stanza 53
(updated on 22/04/2017 09:13)

Proposals for thesis
Gli argomenti di tesi riguardano lo studio dei canali ionici mitocondriali e del loro ruolo nella tumorigenesi. Le tecniche che si possono apprendere in laboratorio riguardano la biologia cellulare, molecolare, la biochimica, oltre ad esperimenti in vivo su modelli di Zebrafish e di topo.

Curriculum Vitae
Group web page: http://www.bio.unipd.it/iicg/
CV pdf: https://syllabus.didattica.unipd.it/docente/CDBF98B84CCA267639F9B7A3E9A363C9/cv.pdf?tipo=ENG

Dr. Luigi Leanza
Assistant Professor in Biochemistry.

2009: PhD in Biosciences, University of Padova
2005: Master Degree in Molecular Biology, University of Padua
2003: First Degree in Molecular Biology, University of Padua

Research experiences:
2016-today: Assistant Professor, Dept. of Biology, University of Padua, Italy.
2013-16: Senior Post Doc, Dept. of Biology, University of Padua.
2009-12: Junior Research Fellow, Dept. of Biology, University of Padua.
2006-09: PhD student, Dept. of Biology, University of Padua.

Research experiences abroad:
2014: EMBO Short Term Fellowship, University of Duisburg-Essen, Germany.
2013: Visiting Scientist, University of Kiel, Germany.
2004: Stage as Erasmus student, Karolinska Institute, Stockholm, Sweden.

2013-2015: Young Scientist Program, University of Padua 2012.
2017-2018: PRID2016, University of Padua.
2017: FFABR, Italian Ministry of Education.

2016: Grant for European Bioenergetic conference (EBEC), Riva del Garda, Italy.
2014: EMBO short term fellowship.
2013: Best presentation at Annual meeting of Italian Group of Bioenergetics and Biomembranes (GIBB).
2011: Travel grant for European Cell Death Organization (ECDO) conference.

2015: Co-author of an application for the patent titled “Psoralen derivatives as selective tumor-killing agents”, n. PD2015A000006, deposited the 15.01.2015.

Co-author of 24 papers published in peer-reviewed journals with impact factor. First, last or corresponding author in 17 papers. Total citations: 487. H index: 12.

1. Mattarei A, et al. (2018) Front. Oncol., 8: 122.
2. Checchetto V, et al. (2018) BBRC, pii:S0006-291X(17)31226-3.
3. Brini M, et al. (2017) Antioxid. Redox Signal., in press.
4. Peruzzo R, et al. (2017) Front. in Oncol., 7: 239.
5. Venturini E, et al. (2017) Neurosignals, 25(1):26-38.
6. Leanza L, et al. (2017) Cancer Cell, 31: 516-31.
7. Zaccagnino A, et al. (2017) Oncotarget, 8(24):38276-93.
8. Peruzzo R, et al. (2016) Eur. Biophys. J., 45: 685-707.
9. Checchetto V, et al. (2016) BBA Bioenergetics, 1857: 1258-66.
10. Leanza L, et al. (2016) BBA Mol. Cell Res., 1863 (2016) 1385-1397
11. Managò A, et al. (2015) Cell Death Dis., 6: e1930.
12. Szabò I, et al. (2015) Cell. Physiol. Biochem., 37: 965-78.
13. Leanza L, et al. (2014) Cell Calcium, pii: S0143-4160(14)00143-2.
14. Leanza L, et al. (2014) Oncogene, 33: 5569-81.
15. Leanza L, et al. (2014) Current Pharmaceutical Design, 20: 189-200.
16. Leanza L, et al. (2013) Frontiers in Physiology, 4: 227.
17. Leanza L, et al. (2013) Leukemia, 27: 1782-85.
18. Leanza L, et al. (2012) Current Medicinal Chemistry, 19: 5394-5404.
19. Checchetto V, et al. (2012) Proc. Nat. Acad. Sci. USA, 109: 11043-48.
20. Leanza L, et al. (2012) EMBO Mol. Med., 4: 577-93.
21. Szabò I, et al. (2012) Pflügers Archiv - Eur. J. Phys., 463: 231-46.
22. Szabò I, et al. (2011) Cell Death Differ., 18: 427-38.
23. Leanza L, et al. (2010) Exp. Cell Res., 316: 3443-53.
24. Leanza L, et al. (2008) J. Biol. Chem., 283: 16437-45.

Conferences and national or international meetings:
I attended to 31 national and international congresses and in 17 of them I have been selected for an oral presentation.

Lecturer's Curriculum (PDF): CDBF98B84CCA267639F9B7A3E9A363C9.pdf

Research areas
The main topic of our research activity is focused on the study of intracellular ion channels as new oncological targets. Several reports have demonstrated that ion channels show an altered expression in several tumor tissues compared to normal ones, suggesting their targeting as a new strategy to eliminate cancer cells. We have recently demonstrated that the pharmacological targeting of a mitochondrial potassium channel, mitoKv1.3, can selectively eliminate cancer cells in vitro, using several cancers cell lines, ex-vivo, using primary cells obtained from patients, and in vivo, using pre-clinical mouse models for melanoma and pancreatic ductal adenocarcinoma (Leanza et al. Cancer Cell 2017). We have several collaborations with other research groups both in Padova and in Europe and USA.

A complete and updated list of publication can be downloaded by the following website https://www.ncbi.nlm.nih.gov/pubmed/?term=leanza+l.

List of taught course units in A.Y. 2019/20
Degree course code (?) Degree course track Course unit code Course unit name Credits Year Period Lang. Teacher in charge
»   SCP4067772 6 1st Year (2019/20) Second
»   SCP4067771 7 1st Year (2019/20) Second
SC1166 COMMON SC02106033 6 3rd Year (2019/20) First