SORIANO GARCIA - CUERVA MARIA EUGENIA

Contacts
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Structure Department of Biology
Telephone 0498276236
Qualification Ricercatore a tempo determinato di tipo B
Scientific sector BIO/11 - MOLECULAR BIOLOGY
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Proposals for thesis
1. Role of ATAD3A in the regulation of mitochondrial ultrastructure, dynamics and mtDNA stability: implications for Mitochondrial Depletion Syndromes and Harel-Yoon disease
2. Exploring the ATAD3B role in lung cancer and chemoresistance.

Curriculum Vitae
Education and Academic appointments

2017 Tenure-Track Assistant Professor, Molecular Biology, Department of Biology, University of Padova, Italy
2014 Assistant Professor, Biochemistry and Mitochondrial Pathophysiology, Department of Biology, University of Padua, Italy.
2004 Ph.D. Dept. of Biomedical Sciences, University of Padova, Italy (Molecular and Cellular Biology and Pathology)
1999 B.S. Biological Degree in Cellular and Molecular Biology, Universidad de Alcalà de Henares, Madrid, Spain.

Research and Professional Experience
2012-2014: Young Investigator Research Contract, Fondazione Telethon: “AUTOMED: Analisi dei mecanismi molecolari dell’autofagia nel cancro ed in patologie degenerative” n. S02016FIRU CUP B81J11002730008, Lab. Prof. L.Scorrano, Venetian Institute of Molecular Medicine (VIMM) and Dept. Biology, University of Padua , Italy.
Project collaboration: Proteomic studies on mitochondrial protein complexes, Lab. Prof. J.A. Enriquez at Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.
2009-2011: Postdoctoral Fellow, Fondazione Telethon: “Extending the cristae remodeling pathway…” n. S02016TELU. Lab. Prof. L.Scorrano,
Project collaboration: Proteomic studies on mitochondrial protein complexes, Lab. Prof. J.A. Enriquez at Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.
2006-2008: Postdoctoral Fellow (Assegno di ricerca): Mitochondria in experimental hepatitis, Lab. Prof. P.Bernardi, Dept. Biomedical Sciences, University of Padua , Italy.
2004-2006: Postdoctoral Fellow (Assegno di ricerca): Mitochondria in experimental hepatitis, Lab. Prof. P.Bernardi, Dept. Biomedical Sciences, University of Padua , Italy.
Research stage: Proteomic studies in mitochondria, Lab. Prof. O.Eriksson at Institute of Biomedicine/Biochemistry, University of Helsinki at Biomedicum , Finland.
2001-2004 Research Fellow: Mitochondrial Pathophysiology, Lab Prof. P.Bernardi, Dept. of Biomedical Sciences, University of Padua, Italy
Research stage: Proteomic studies in mitochondria, Lab. Prof. O.Eriksson at Institute of Biomedicine/Biochemistry, University of Helsinki at Biomedicum , Finland.
2000-2001 Research Fellow from Fidia S.p.A.: Mitochondria and Apoptosis. Lab. Prof. Paolo Bernardi, Dept. Biomedical Sciences, University of Padua, Italy.
1999-2000 Postgraduate Fellowship. Lab. Prof. Paolo Bernardi, Dep. Biomedical Sciences, University of Padua, Italy.
1998-1999 Bachelor Thesis: Role of Acid Sphingomielinase in Apoptosis, Lab. Prof. R.Testi, Dept. of Experimental Medicine, University of Tor Vergata , Rome, Italy.

Research areas
Mitochondrial diseases are a heterogeneous group of disorders characterized by a dysfunctional OXPHOS activity. A growing number of mutations in mitochondrial proteins codified by nuclear or mitochondrial DNA (mtDNA) has been associated with mitochondrial disorders. However, the number is still increasing. A crucial aspect to ensure a correct mitochondrial function is the maintenance of mtDNA, ensuring its segregation, replication, and functioning. Our research interest is to understand the molecular mechanisms regulating mtDNA dynamics, and how alteration in this process might affect the onset or progression of mitochondrial diseases.

Publications
Tezze C, Romanello V, Desbats MA, Fadini GP, Albiero M, Favaro G, Ciciliot S, Soriano ME, Morbidoni V, Cerqua C, Loefler S, Kern H, Franceschi C, Salvioli S,Conte M, Blaauw B, Zampieri S, Salviati L, Scorrano L, Sandri M. Age-Associated Loss of OPA1 in Muscle Impacts Muscle Mass, Metabolic Homeostasis, Systemic Inflammation, and Epithelial Senescence. Cell Metab. 2017 Jun 6;25(6):1374-1389.e6. doi: 10.1016/j.cmet.2017.04.021


Quintana-Cabrera R, Mehrotra A, Rigoni G, Soriano ME. Who and how in the regulation of mitochondrial cristae shape and function. Biochem Biophys Res Commun. 2017 Apr 21. pii: S0006-291X(17)30763-5. doi: 10.1016/j.bbrc.2017.04.088.

Glytsou C , Calvo E, Anastasia I, Cogliati S, Raimondi A, Mehrotra A, Shintani N, Loureiro M, Vazquez J, Pellegrini L, Enriquez JA, and Scorrano L, Soriano ME. Optic Atrophy 1 epistatically effects the core MICOS component mitofilin to control mammalian mitochondria cristae shape. Cell Reports 2016 Dec 13;17(11):3024-3034. doi: 10.1016/j.celrep.2016.11.049.

Corrado M, Mariotti FR, Trapani L, Taraborrelli L, Nazio F, Cianfanelli V, Soriano ME, Schrepfer E, Cecconi F, Scorrano L, Campello S. Macroautophagy inhibition maintains fragmented mitochondria to foster T cell receptor-dependent apoptosis. EMBO J. 2016 Aug 15;35(16):1793-809.
Carbognin E, Betto RM, Soriano ME, Smith AG, Martello G. Stat3 promotes mitochondrial transcription and oxidative respiration during maintenance and induction of naive pluripotency. EMBO J. 2016 Mar 15;35(6):618-34.
Papathanasiou S, Rickelt S*, Soriano ME*, Schips TG, Maier HJ, Davos CH, Varela A, Kaklamanis L, Mann DL, Capetanaki Y. Tumor necrosis factor-α confers cardioprotection through ectopic expression of keratins K8 and K18. Nat Med. 2015 Sep;21(9):1076-84.
Lavatelli F, Imperlini E, Orrù S, Rognoni P, Sarnataro D, Palladini G, Malpasso G, Soriano ME, Di Fonzo A, Valentini V, Gnecchi M, Perlini S, Salvatore F, Merlini G. Novel mitochondrial protein interactors of immunoglobulin light chains causing heart amyloidosis. FASEB J. 2015 Nov;29(11):4614-28.
Varanita T, Soriano ME, Romanello V, Zaglia T, Quintana-Cabrera R, Semenzato M, Menabò R, Costa V, Civiletto G, Pesce P, Viscomi C, Zeviani M, Di Lisa F, Mongillo M, Sandri M, Scorrano L. The OPA1-dependent mitochondrial cristae remodeling pathway controls atrophic, apoptotic, and ischemic tissue damage. Cell Metab. 2015 Jun 2;21(6):834-44.
Calì T, Ottolini D, Soriano ME, Brini M. A new split-GFP-based probe reveals DJ-1 translocation into the mitochondrial matrix to sustain ATP synthesis upon nutrient deprivation. Hum Mol Genet. 2015 Feb 15;24(4):1045-60.
Cogliati S, Frezza C, Soriano ME, Varanita T, Quintana-Cabrera R, Corrado M, Cipolat S, Costa V, Casarin A, Gomes LC, Perales-Clemente E, Salviati L, Fernandez-Silva P, Enriquez JA, Scorrano L. Mitochondrial cristae shape determines respiratory chain supercomplexes assembly and respiratory efficiency. Cell. 2013 Sep 26;155(1):160-71.
Soriano ME, Scorrano L. Traveling Bax and forth from mitochondria to control apoptosis. Cell. 2011 Apr 1;145(1):15-7.
Soriano ME, Scorrano L. The interplay between BCL-2 family proteins and mitochondrial morphology in the regulation of apoptosis. Adv Exp Med Biol. 2010;687:97-114.
Bisaglia M, Soriano ME, Arduini I, Mammi S, Bubacco L. Molecular characterization of dopamine-derived quinones reactivity toward NADH and glutathione: implications for mitochondrial dysfunction in Parkinson disease. Biochim Biophys Acta. 20

List of taught course units in A.Y. 2019/20
Degree course code (?) Degree course track Course unit code Course unit name Credits Year Period Lang. Teacher in charge
SC1165 COMMON SCP4068094   ENG MAURO AGOSTINO ZORDAN
»   SCP4068095 7 2nd Year (2019/20) First
semester
ENG MAURO AGOSTINO ZORDAN
»   SCP4068096 7 2nd Year (2019/20) First
semester
ENG MARIA EUGENIA SORIANO GARCIA - CUERVA