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Structure Department of Biomedical Sciences
Telephone 0498276409
Qualification Professore ordinario
Scientific sector BIO/10 - BIOCHEMISTRY
University telephone book  Show

Office hours
Complesso Vallisneri, via G. Colombo 3, 35131 Padova o Via Ogo Bassi 58 B, 35131 Padova Sempre, su appuntamento prenotato per email
(updated on 23/04/2019 10:30)

Proposals for thesis
Il lavoro di tesi (per laurea magistrale) consiste nel clonaggio, espressione e purificazione di proteine globulari; loro cristallizzazione e determinazione della struttura mediante diffrazione dei raggi X.
I sistemi di interesse del gruppo di ricerca sono le proteine del patogeno umano Helicobacter pylori e alcune proteine di membrana. Maggiori dettagli sono riportato nel sito:

Curriculum Vitae
Giuseppe Zanotti graduated in chemistry in Padua in 1974 and he is now Full Professor at the Faculty of Sciences of the same University. Since the beginning of its scientific career he has worked at the determination of the structure of molecules and macromolecules through x-ray diffraction. After a Dr degree dissertation on bovine pancreatic Ribonuclease, he has been always active in the field of structural biology. In 1979-80 he has spent one year at the Laboratory of Molecular Biophysics in Oxford, working with Louise Johnson on the structure of glycogen phosphorylase b. Back to Padua (Associate Professor in 1983, Full Professor in 2000), he has been interested in proteins that bind and transport small hydrophobic molecules, in the structural determination of protein kinase CK2/inhibitor complexes and, more recently, in that of proteins from pathogenic bacteria, in particular H. pylori.
Giuseppe Zanotti has also been interested in theoretical aspects of the phase problem in crystallography and on the analysis and conformational aspects of the structure of globular proteins.
He has published more than 210 papers on international journals, 16 book chapters and some didactic books. He has deposited more than 148 protein structures at the PDB.
H-index 38, citations 5024 (Scopus).

Research areas

- Biologia strutturale - Biocristallografia
- Cryo-electron microscopy
- Helicobacter pylori
- Calcium transport proteins

Pubblicazioni scelte

1.I. RAMAZZINA, L. CENDRON, C. FOLLI, R. BERNI, D. MONTEVERDI, G. ZANOTTI, AND R. PERCUDANI "Logical identification of an allantoinase analog (puuE) recruited from polysaccharide deacetylases" J. Biol. Chem. (2008) 283, 23295-23304
2. L. CENDRON, M. COUTURIER, A. ANGELINI, N. BARISON, M. STEIN AND G. ZANOTTI “The Helicobacter pylori CagD (HP0545, Cag24) protein is required for CagA translocation but not for type IV secretion pilus assembly” J. Mol. Biol. (2009) 386, 204-217
3. L. CENDRON, A. TROVATO, F. SENO, C. FOLLI, B. ALFIERI, G. ZANOTTI AND R. BERNI “Amyloidogenic potential of transthyretin variants: insights from structural and computational analysis” J. Biol. Chem. (2009) 284, 25832-25841
4. I. RAMAZZINA, R. COSTA, L. CENDRON, R. BERNI, A. PERACCHI, G. ZANOTTI, AND R. PERCUDANI “An aminotransferase branch point connects purine catabolism to amino acid recycling” Nature Chem. Biol. (2010), 6, 801-806, doi:10.1038/NCHEMBIO.445
5. G. ZANOTTI AND L. CENDRON “Structural and functional aspects of Helicobacter pylori acidic stress response” IUBMB Life (2010), 62, 715-723, DOI: 10.1002/iub.382
6.L. CENDRON, I. RAMAZZINA, R. PERCUDANI, C. RASORE, G. ZANOTTI, R. BERNI “Probing the evolution of hydroxyisourate hydrolase into transthyretin through active site redesign” J. Mol. Biol., (2011) 409, 504-512
7. L. CENDRON, P. BERTO, S. D’ADAMO, F. VALLESE, C. GOVONI, M.C. POSEWITZ, G.M GIACOMETTI, P. COSTANTINI, G. ZANOTTI “Crystal structure of YhdF scaffold protein provides insights into [FeFe]-hydrogenase maturation” J. Biol. Chem. (2011), 286, 43944-43950
8. A. ANGELINI, L. CENDRON, S. CHEN, J. TOUATI, G. WINTER, G. ZANOTTI, AND C. HEINIS Bicyclic peptide inhibitor reveals large contact interface with a protease target. ACS Chem. Biol. (2012) 7, 817-821. DOI: 10.1021/cb200478t
9. MONTECUCCO C. AND ZANOTTI G., Botulinum neurotoxin A1 likes it double sweet, Nat. Struct. Mol. Biol. (2016) 23, 619-621.
10. BERCSENYI, N. SCHMIEG, J. B. BRYSON, M. WALLACE, P. CACCIN, M. GOLDING, G. ZANOTTI, L. GREENSMITH, R. NISCHT, G. SCHIAVO “Nidogens are therapeutic targets for the prevention of tetanus” Science, (2014) 346, 1118-1123 doi: 10.1126/science.1258138

Lecturer's Publications (PDF): B4997DF1F539EE282ECC9C7832B1559B.pdf

List of taught course units in A.Y. 2019/20
Degree course code (?) Degree course track Course unit code Course unit name Credits Year Period Lang. Teacher in charge
ME1853 COMMON MEN1033430 7 1st Year Annual ITA MIRELLA ZANCATO
ME1727 COMMON MEP5072539 8 1st Year First