DALL'ACQUA STEFANO

Contacts
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B17dc354ef4b5369419d0e554d66a7a7
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Structure Department of Pharmaceutical and Pharmacological Sciences
Telephone 0498275332
Qualification Professore associato confermato
Scientific sector CHIM/08 - PHARMACEUTICAL CHEMISTRY
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Proposals for thesis
Il Laboratorio dei Prodotti Naturali si occupa di chimica dei prodotti naturali.
Le linee di ricerca attualmente attive sono

1) Isolamento e caratterizzazione di costituenti con potenziale attività biologica da fonti botaniche scarsamente studiate, da specie con usi medicinali tradizionali, da altri organismi naturali.
Isolamento di costituenti bioattivi mediante approcci "bioassay-guided".

2) Sviluppo di metodiche analitiche HPLC-MS, HPLC-Fluorescenza, HPLC-DAD, HPLC-ELSD, GC-MS, GC-FID per l'analisi di prodotti naturali in matrici complesse (prodotti vegetali, specie botaniche, specie edibili, prodotti farmaceutici)

3) Valutazione del contenuto in metaboliti secondari e sostanze caratterizzanti in specie vegetali edibili o medicinali in collaborazione con altri gruppi di ricerca.

4) Valutazione di antiossidanti naturali in modelli in vivo mediante approccio Metabolomico.

Curriculum Vitae
Dall’Acqua Stefano, graduated in Chemistry and Pharmaceutical Technology cum laude in 1998 at the University of Padova. PhD (2003) in pharmaceutical Sciences working on the chemistry of natural products, defending a thesis titled “Bioactive compounds from Italian Plants”. Research grant at the Department of Pharmaceutical Science University of Padova. Post-Doc grant at the same Department with a research program entitled “Isolation and characterization of estrogenic compounds from natural sources”. Research grant in 2006 with a project “Bioactive compounds from Nepalese medicinal plants”. Researcher from of October 2007 (SSd CHIM08) at the Faculty of Pharmacy of the University of Padova.
Teaching activity as Assistant professor at University of Padova for Pharmacy, Medicinal Chemistry and Thecnology, Applied Pharmaceutical Sciences. The research activity deal with the medicinal chemistry and mainly with the chemistry of natural products. Main topics are the isolation and structural determination of natural compounds with high focus on 1D and 2D NMR and MS spectroscopy and the development of analytical methods for the determination of natural products in complex mixtures (HPLC-DAD, HPLC-MS, UPLC-DAD-MS, HPLC-Fluorescence, HPLC-ELSD, GC-FID, GC-MS). Chemical classes of natural compounds investigated are lignans, xanthones, alkaloids, flavonoids, saponins, terpenoids, lipids. Further research activity deal with in vivo absorbtion of natural products and in vivo and clinical effects of phytochemicals as well as study of phytochemical effects by metabolomic approach. Author and co-author in more than 100 published papers.

Research areas
Chimica dei prodotti naturali, isolamento caratterizzazione di sostanze naturali. Tecniche impiegate, tecniche estrattive, separazioni cromatografiche (Cromatografia su colonna, Flash cromatografia, HPLC analitico e preparativo), tecniche spettrometriche (HPLC-MS, MS, HR-MS, 1D e 2D NMR).
Sviluppo metodi analitici mediante HPLC accoppiato a detector DAD, Fluorescenza, ELSD, MS, mediante GC FID e GC-MS. Analisi di elementi in tracce mediante tecniche di assorbimento atomico.

Studi in vivo sulla somministrazione di prodotti naturali in modelli animali. Studio metabolomico mediante approcci di tipo HPLC-MS e NMR ed elaborazione dei dati mediante tecniche multivariate.

Publications


Lecturer's Publications (PDF): B17DC354EF4B5369419D0E554D66A7A7.pdf

List of taught course units in A.Y. 2019/20
Degree course code (?) Degree course track Course unit code Course unit name Credits Year Period Lang. Teacher in charge
FA1732 COMMON MEP3051841 6 5th Year (2019/20) First
semester
ITA STEFANO DALL'ACQUA
FA1733 COMMON FAM1027060 10 3rd Year (2019/20) Second
semester
ITA STEFANO DALL'ACQUA