MEGIGHIAN ARAM

Contacts
E-mail
A512163bd0937e5ec8270b81a54e0b37
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Structure Department of Biomedical Sciences
Telephone 0498276863
Qualification Professore associato confermato
Scientific sector BIO/09 - PHYSIOLOGY
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Notice and additional information

@ https://elearning.unipd.it/dsb/

you can find a dedicated site (Aram Megighian) where all informations (Programs, useful suggested readings, slides pdf) about Courses where he's teacher are present.

Office hours
Si riceve previo appuntamento concordato tramite e-mail
(updated on 05/05/2018 19:09)

Proposals for thesis
Dissertations and Original Researches are proposed for the final discussion for acquiring the degree in Courses where Prof Megighian is faculty member as well as in other Courses in collaboration with the proper faculty members.


Suggested arguments

Study of the evolutively maintained molecular nanomachine regulating neurotransmitter release in chemical synapses, using combined genetic, molecular and neurophysiological techniques in fruitflies.

Adaptive behaviors in response to sudden environmental modifications (i.e., food finding; predator identification; detection of another individual) have and had an enormous evolutive significance. They are based on fundamental brain processes similar among different and evolutively distant organisms (i.e. invertebrates and vertebrates). Are these similar mechanisms sharing also similar neural circuits and neurotransmitters ? Or, differently, did evolution "found" different functional strategies to process these similar adaptive behaviors ?
Using as model the fruitfly and the possibility to combine in this model sophisticated genetic, neurophysiological, and behavioral techniques, are investigated in this invertebrate complex behaviors like wake/sleep cycle, social interactions, decision making and action selection processes, selective attention, reward and fear behaviors.

Utilized techniques: behavioral quantitative analysis using video tracking techniques and offline computer analysis; simple genetic techniques (fruitfly lines crossings and selection of specific mutants using phenotipic markers); confocal microscopy techniques; neurophysiology and electrophysiology techniques.

On the basis of Lab multidisciplinary approaches and collaborations, students are involved in a stimulating and collaborative environment together with other students developing in turn their thesis.

Curriculum Vitae
Education
1988- MD, magna cum laude. University of Padova
1992- Residency in Neurology, magna cum laude. University of Padova

Academic qualifications
1988-1992 Fellow. Institute of Human Physiology, University of Padova
1992-2010 Assistant Professor in Physiology, Institute of Human Physiology. University of Padova
2010- Associate Professor in Physiology. Del of Biomedical Sciences. University of Padova
2005-2011 Faculty Board of Neuroscience PhD Program
2011-2012 Faculty Board of Neurobiology PhD Program
2012-2018 Faculty Board of Biomedica Sciences PhD Program
2018- Faculty Board PhD of Padova Neuroscience Center (PNC)
1997- Adjunct Professor, Del of Biology, San Diego State University

SCIENTIFIC ACTIVITY

Past

Neural control of skeletal muscle function: role of motor neuron activity, neurotrophic factors, nerve-muscle signalling, ageing, on Excitation, Excitation-Coupling and Contraction processes of skeletal muscle fibres from rodent models.

Current

Study of the evolutively maintained molecular nanomachine regulating neurotransmitter release in chemical synapses, using combined genetic, molecular and neurophysiological techniques in fruitflies.

Adaptive behaviors in response to sudden environmental modifications (i.e., food finding; predator identification; detection of another individual) have and had an enormous evolutive significance. They are based on fundamental brain processes similar among different and evolutively distant organisms (i.e. invertebrates and vertebrates). Are these similar mechanisms sharing also similar neural circuits and neurotransmitters ? Or, differently, did evolution "found" different functional strategies to process these similar adaptive behaviors ?
Using as model the fruitfly and the possibility to combine in this model sophisticated genetic, neurophysiological, and behavioral techniques, are investigated in this invertebrate complex behaviors like wake/sleep cycle, social interactions, decision making and action selection processes, selective attention, reward and fear behaviors.

Lecturer's Curriculum (PDF): A512163BD0937E5EC8270B81A54E0B37.pdf

Research areas
Study of the evolutively maintained molecular nanomachine regulating neurotransmitter release in chemical synapses, using combined genetic, molecular and neurophysiological techniques in fruitflies. Alterations of these molecular components are observed in some psychiatric diseases (i.e. schizophrenia, depression, autism) where they can led to a synaptic dysfunction, to a consequent modification of postsynaptic integration and, finally, to an altered information coding fo post-synaptic neurons.

Adaptive behaviors in response to sudden environmental modifications (i.e., food finding; predator identification; detection of another individual) have and had an enormous evolutive significance. They are based on fundamental brain processes similar among different and evolutively distant organisms (i.e. invertebrates and vertebrates). Are these similar mechanisms sharing also similar neural circuits and neurotransmitters ? Or, differently, did evolution "found" different functional strategies to process these similar adaptive behaviors ?
Using as model the fruitfly and the possibility to combine in this model sophisticated genetic, neurophysiological, and behavioral techniques, are investigated in this invertebrate complex behaviors like wake/sleep cycle, social interactions, decision making and action selection processes, selective attention, reward and fear behaviors.

Publications
To obtain a complete list of publications, copy and paste the below link on the URL address of your Browser.

http://www.ncbi.nlm.nih.gov/pubmed/?term=Megighian+a

List of taught course units in A.Y. 2019/20
Degree course code (?) Degree course track Course unit code Course unit name Credits Year Period Lang. Teacher in charge
ME1726 COMMON MEP6077020 11 3rd Year First
semester
ITA ARAM MEGIGHIAN
ME1727 COMMON MEP6077020 11 3rd Year First
semester
ITA ARAM MEGIGHIAN
FA1732 COMMON MEL1000388 10 2nd Year Second
semester
ITA ARAM MEGIGHIAN