SANDRELLI FEDERICA

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Structure Department of Biology
Telephone 0498276216
Qualification Professore associato confermato
Scientific sector BIO/18 - GENETICS
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Office hours
Dipartimento di Biologia, II semipiano sud, stanza 16 tutti i giorni, previo appuntamento telefonico o via email
(updated on 10/07/2013 19:24)

Proposals for thesis
Bachelor and Master Degree theses will be focussed on the following research topics:
• Antimicrobial Peptides (AMPs) and innate immune response in B. mori. Four topics are addressed: i) generation of transgenic silkworms producing an AMP-enriched silk; ii) Genetic differences in the innate immune response among laboratory and commercial silkworm strains; iii) Mechanism of action of specific silkworm AMPs, candidates for drug development; iv) the circadian control of the innate immune response in B. mori.
• Analysis of circadian clock and other behavioral genes in insects. This research has been focused on the molecular and functional analyses of circadian and other behavioral genes in the fruit fly Drosophila melanogaster and other insects, developing studies including developmental and behavioral analyses, transgenesis, cellular and molecular analyses (at DNA, RNA and protein levels). The ongoing study has the aim to characterize the in vivo transcriptomic variations in Drosophila adult brain neurons (dopaminergic neurons), under normal and oxidative stress- generating environments and in different mutant backgrounds.

Curriculum Vitae
EDUCATION
• Degree in Biology (110/110 cum laude,University of Padova), 1992
• PhD in Genetics (University of Ferrara; Consortium among Universities of Bologna, Ferrara, Padova, Parma and Pisa), 1998

PROFESSIONAL EXPERIENCE
• Post graduate fellow of ”Associazione Italiana Ricerca sul Cancro” (AIRC) at the Department of Biology, University of Padova, 1993-1994
• PhD student in Genetics (University of Ferrara; Consortium among Universities of Bologna, Ferrara, Padova, Parma and Pisa), 1994-1997.
• Erasmus PhD student at the Department of Genetics, University of Leicester, UK, 1995
• Postdoc (University Hospital, Univeristy of Padova), 1997-1999
• Assistant Professor (Genetics) (University of Padova), 1999-2011
• Associate Professor (Scientific Disciplinary Sector BIO/18-Genetics) at the University Padova, Department of Biology, 2011-present
• Visiting Scientist (University of Fribourg, Fribourg (CH)), 2012-2013

RESEARCH ACTIVITY
Main research topics:
• Antimicrobial Peptides (AMPs) and innate immune response in B. mori. Four topics are addressed: i) generation of transgenic silkworms producing an AMP-enriched silk; ii) Genetic differences in the innate immune response among laboratory and commercial silkworm strains; iii) Mechanism of action of specific silkworm AMPs, candidates for drug development; iv) the circadian control of the innate immune response in B. mori.
• Analysis of circadian clock and other behavioral genes in insects. This research has been focused on the molecular and functional analyses of circadian and other behavioral genes in the fruit fly D. melanogaster and other insects (B. mori, C. capitata), developing studies including developmental and behavioral analyses, transgenesis, cellular and molecular analyses (at DNA, RNA and protein levels).Currently, she is developing a study to characterize the in vivo transcriptomic variations in Drosophila adult brain neurons (dopaminergic neurons), under normal and oxidative stress- generating environments and in different mutant backgrounds.

TEACHING ACTIVITY
• “Genetics” for the first-level degree (Bachelor) in Biotechnology and Natural Science, University of Padova 2000-present
• Invited Professor in the “Spring school of Chronobiology” for PhD students in Haren, Netherlands, June 2004.
• She acquired the Teaching4Learning Badge from University of Padova, 2018
• Tutor of about 30 theses for Bachelor degree and 6 theses for Master degree
• Supervisor of 2 PhD students and 3 PostDocs.

BOARD OF PhD PROGRAMS
• Member of the board of professors of the PhD School in “Biosciences”, Curriculum “Genetics Genomics and Bioinformatics”, University of Padova, 2018
• Member of the board of professors of the PhD School of “Biosciences and Biotechnology”, Curriculum “Genetics and Developmental Molecular Biology”, University of Padova 2009-2015.


Lecturer's Curriculum (PDF): 99903C0CE1E605CEC88599EF6C56E625.pdf

Research areas

Main research topics:
• Antimicrobial Peptides (AMPs) and innate immune response in B. mori. Four topics are addressed: i) generation of transgenic silkworms producing an AMP-enriched silk; ii) Genetic differences in the innate immune response among laboratory and commercial silkworm strains; iii) Mechanism of action of specific silkworm AMPs, candidates for drug development; iv) the circadian control of the innate immune response in B. mori.
• Analysis of circadian clock and other behavioral genes in insects. This research has been focused on the molecular and functional analyses of circadian and other behavioral genes in the fruit fly Drosophila melanogaster and other insects (Bombyx mori, Ceratitis capitata), developing studies including developmental and behavioral analyses, transgenesis, cellular and molecular analyses (at DNA, RNA and protein levels).Currently, she is developing a study aims to characterized the in vivo transcriptomic variations in Drosophila adult brain neurons (dopaminergic neurons), under normal and oxidative stress- generating environments and in different mutant backgrounds.
• Study on the possible link between the circadian clock and psychiatric disorders. This part of the work was developed using both Drosophila and mouse models. To this aim she spent one year (12-13) in the laboratory of Prof. Albrecht (University of Fribourg, CH) to use the mouse as a model organism for analyzing both circadian clock and psychiatric-like behaviors.

Publications
Pubblications 2010-18
1. Alessio Saviane, Ottavia Romoli, Andrea Bozzato, Giuliano Freddi, Chiara Cappelletti, Elena Rosini, Silvia Cappellozza, Gianluca Tettamanti and Federica Sandrelli: Intrinsic antimicrobial properties of silk spun by genetically modified silkworm strains. Transgenic Research_ 27:87–101

2. Biosa A, Sandrelli F, Beltramini M, Greggio E, Bubacco L, Bisaglia M. (2017): Recent findings on the physiological function of DJ-1: Beyond Parkinson's disease. Neurobiol Dis. 108:65-72.

3. Romoli O, Saviane A, Bozzato A, D'Antona P, Tettamanti G, Squartini A, Cappellozza S, Sandrelli F. (2017): Differential sensitivity to infections and antimicrobial peptide-mediated immune response in four silkworm strains with different geographical origin. Sci Rep. 7:1048.

4. Schnell A, Sandrelli F, Ranc V, Ripperger JA, Brai E, Alberi L, Rainer G, Albrecht U. (2015): Mice lacking circadian clock components display different mood-related behaviors and do not respond uniformly to chronic lithium treatment. Chronobiol Int. 2015 Oct;32(8):1075-89.

5. Zordan MA, Sandrelli F (2015): Circadian Clock Dysfunction and Psychiatric Disease: Could Fruit Flies have a Say? Frontiers in Neurology vol. 6, p. 1-16.

6. Schnell A , Albrecht U, Sandrelli F (2014): Rhythm and Mood: Relationships Between the Circadian Clock and Mood-Related Behavior. Behavioral Neuroscience, vol. 128, p. 326-343

7. Baggio F, Bozzato A, Benna C, Leonardi E, Romoli O, Cognolato M, Tosatto SC, Costa R, Sandrelli F (2013): 2mit, an Intronic Gene of Drosophila melanogaster timeless2, Is Involved in Behavioral Plasticity. PLos One, vol. 8

8. Vanin S, Bhutani S, Montelli S, Menegazzi P, Green EW, Pegoraro M, Sandrelli F, Costa R, Kyriacou CP (2012): Unexpected features of Drosophila circadian behavioural rhythms under natural conditions. Nature, vol. 484, p. 371-375

9. Benna C, Bonaccorsi S, Wülbeck C, Helfrich-Förster C, Gatti M, Kyriacou C P, Costa R, Sandrelli F (2010): Drosophila timeless2 is required for chromosome stability and circadian photoreception. Curr Biol 20, 346-352.

Lecturer's Publications (PDF): 99903C0CE1E605CEC88599EF6C56E625.pdf

List of taught course units in A.Y. 2018/19
Degree course code (?) Degree course track Course unit code Course unit name Credits Year Period Lang. Teacher in charge
IF1839 COMMON SC11103434 7 1st Year Second
semester
ITA FEDERICA SANDRELLI
SC1161 COMMON SC07103434 6 2nd Year First
semester
ITA FEDERICA SANDRELLI