PILICHOU KALLIOPI

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Structure Department of Cardiac, Thoracic and Vascular Sciences
Telephone 0498272293
Qualification Ricercatore universitario confermato
Scientific sector MED/08 - PATHOLOGICAL ANATOMY
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Office hours
Thursday from 10:00 to 17:00 su appuntamento
(updated on 08/05/2014 13:56)

Proposals for thesis
Next Generation sequencing and genotype-phenotype correlation in juvenile sudden cardiac death.
Next Generation sequencing and genotype-phenotype correlation in the the athletes.
Next Generation sequencing and genotype-phenotype correlation in arrhythmic cardiomyopathies.

Curriculum Vitae
Kalliopi Pilichou, assistant professor (SSD MED/08) in the Dept. of Cardiac, Thoracic and Vascular Sciences- University of Padua Medical School. Graduated in Biological Sciences at the University of Padua in 2003. She carried out her residency in Medical Genetics in 2012 at the University of Padua.
Dr. Pilichou completed her PhD studies in Cardiovascular Sciences in 2006 carrying out research in molecular biology and genetics of heredo-familial cardiomyopathies. Specifically, she identified and associated mutations in desmoglein-2 gene (DSG2) with Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC), providing a significant contribution to the understanding of the genetic origin of this disease and to the early diagnosis of ARVC patients and their asymptomatic relatives (Pilichou K et al., Circulation, 2006).
Subsequently, in 2006, she sought two international collaborations with experts in the field of transgenesis, one with Dr. C.R. Bezzina (Academic Medical Center, Amsterdam, the Netherlands), where she established as a visiting researcher, a transgenic animal model (N271S dsg2) recapitulating major clinical and pathological features of the disease, and in parallel a second collaboration with the group of Prof. R.E. Leube (Johannes Gutenberg- University Mainz, Germany), who kindly shared the dsg2 knock-out model for electric and morphologic cardiac investigation (Pilichou K et al., JEM, 2009).
The research of Dr. Pilichou in cardiac sudden death and cardiomyopathies was published in high-ranking journals of the cardiovascular field, i.e. Circulation, J Exp Med, J Am Coll Cardiol, Eur Heart J with total impact factor 222,518 (IF medio 7.18, H-index 14, Citations 1070).
Since 2006 she is a fellow/member of Italian Society of Cardiology, Italian Association of Cardiovascular Pathology, Association for European Cardiovascular Pathology, European Society of Human Genetics and European Society of Human Genetics. Her studies have been awarded by 6 national and international prizes: in 2006 she received the International award 'Massimo Castagnini' of the Società Italiana di Medicina Legale e delle Assicurazioni, in 2007 she received a scholar for her research in international istitutions from the Italian Society of Cardiology, in 2008 a Travel Grant from the Association for European Cardiovascular Pathology and in the same year she received by the Italian Society of Cardiology an Award for the best abstract presented in cardiovascular science during the American Heart Association Conference in New Orleans-2008, in 2009 she has been awarded with the prize “Giorgio Olivetti” of the Italian Association of Cardiovascular Pathology and the prize for the best publication in international scientific journals of cardiovascular science by the Italian Society of Cardiology, finally in 2012 she received the prize for the ‘best presentation’ from the Association for European Cardiovascular Pathology.
Dr. Pilichou, principal investigator and participant in national and international grants. Teaching duties since 2011: Pathological anatomy for the Dental Care course, and Medicine at the University of Padua.

Publications
1: Pilichou K, Thiene G, Bauce B, Rigato I, Lazzarini E, Migliore F, Perazzolo
Marra M, Rizzo S, Zorzi A, Daliento L, Corrado D, Basso C. Arrhythmogenic
cardiomyopathy. Orphanet J Rare Dis. 2016 Apr 2;11:33. doi:
10.1186/s13023-016-0407-1. Review. PubMed PMID: 27038780; PubMed Central PMCID:
PMC4818879.

2: Pilichou K, Thiene G, Basso C. Assessing the significance of pathogenic
mutations and autopsy findings in the light of 2010 arrhythmogenic right
ventricular cardiomyopathy diagnostic criteria: a clinical challenge. Circ
Cardiovasc Genet. 2012 Aug 1;5(4):384-6. doi: 10.1161/CIRCGENETICS.112.964163.
PubMed PMID: 22896011.

3: Bauce B, Rampazzo A, Basso C, Mazzotti E, Rigato I, Steriotis A, Beffagna G,
Lorenzon A, De Bortoli M, Pilichou K, Marra MP, Corbetti F, Daliento L, Iliceto
S, Corrado D, Thiene G, Nava A. Clinical phenotype and diagnosis of
arrhythmogenic right ventricular cardiomyopathy in pediatric patients carrying
desmosomal gene mutations. Heart Rhythm. 2011 Nov;8(11):1686-95. doi:
10.1016/j.hrthm.2011.06.026. Epub 2011 Jun 30. PubMed PMID: 21723241; PubMed
Central PMCID: PMC3205183.

4: Pilichou K, Bezzina CR, Thiene G, Basso C. Arrhythmogenic cardiomyopathy:
transgenic animal models provide novel insights into disease pathobiology. Circ
Cardiovasc Genet. 2011 Jun;4(3):318-26. doi: 10.1161/CIRCGENETICS.110.959031.
Review. PubMed PMID: 21673311.

5: Xu T, Yang Z, Vatta M, Rampazzo A, Beffagna G, Pilichou K, Scherer SE,
Saffitz J, Kravitz J, Zareba W, Danieli GA, Lorenzon A, Nava A, Bauce B, Thiene
G, Basso C, Calkins H, Gear K, Marcus F, Towbin JA; Multidisciplinary Study of
Right Ventricular Dysplasia Investigators. Compound and digenic heterozygosity
contributes to arrhythmogenic right ventricular cardiomyopathy. J Am Coll
Cardiol. 2010 Feb 9;55(6):587-97. doi: 10.1016/j.jacc.2009.11.020. Erratum in: J
Am Coll Cardiol. 2010 Mar 30;55(13):1401. Pillichou, Kalliopi [corrected to
Pilichou, Kalliopi]. PubMed PMID: 20152563; PubMed Central PMCID: PMC2852685.

6: Pilichou K, Remme CA, Basso C, Campian ME, Rizzo S, Barnett P, Scicluna BP,
Bauce B, van den Hoff MJ, de Bakker JM, Tan HL, Valente M, Nava A, Wilde AA,
Moorman AF, Thiene G, Bezzina CR. Myocyte necrosis underlies progressive
myocardial dystrophy in mouse dsg2-related arrhythmogenic right ventricular
cardiomyopathy. J Exp Med. 2009 Aug 3;206(8):1787-802. doi: 10.1084/jem.20090641.
Epub 2009 Jul 27. PubMed PMID: 19635863; PubMed Central PMCID: PMC2722163.


7: Basso C, Czarnowska E, Della Barbera M, Bauce B, Beffagna G, Wlodarska EK,
Pilichou K, Ramondo A, Lorenzon A, Wozniek O, Corrado D, Daliento L, Danieli GA,
Valente M, Nava A, Thiene G, Rampazzo A. Ultrastructural evidence of intercalated
disc remodelling in arrhythmogenic right ventricular cardiomyopathy: an electron
microscopy investigation on endomyocardial biopsies. Eur Heart J. 2006
Aug;27(15):1847-54. Epub 2006 Jun 14. PubMed PMID: 16774985.


8: Pilichou K, Nava A, Basso C, Beffagna G, Bauce B, Lorenzon A, Frigo G,
Vettori A, Valente M, Towbin J, Thiene G, Danieli GA, Rampazzo A. Mutations in
desmoglein-2 gene are associated with arrhythmogenic right ventricular
cardiomyopathy. Circulation. 2006 Mar 7;113(9):1171-9. Epub 2006 Feb 27. PubMed
PMID: 16505173.

List of taught course units in A.Y. 2018/19
Degree course code (?) Degree course track Course unit code Course unit name Credits Year Period Lang. Teacher in charge
ME1726 COMMON MEP7081577 4 1st Year First
semester
ENG KALLIOPI PILICHOU
ME1854 COMMON MEN1033923 10 1st Year Second
semester
ITA KALLIOPI PILICHOU