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Structure Department of Biology
Telephone 0498276335
Qualification Professore associato confermato
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Office hours
Monday from 15:00 to 16:00 Studio situato al 5° piano sud del Complesso Biologico A. Vallisneri viale G. Colombo, 3 Gli studenti sono pregati di fissare un appuntamento scrivendo a
(updated on 01/05/2018 12:27)

Proposals for thesis
In general, the thesis topics are focused on the identification of strategies to increase the efficacy and selectivity of anticancer therapies.

The approaches are based on:
a) combinations of chemotherapeutics of different nature that act on different cellular targets and with non-overlapping mechanisms creating a synergistic interaction;
b) combinations of different therapeutic modalities such as chemotherapy and photodynamic therapy. Photodynamic therapy is also effective in drug-resistant tumors and is a good adjuvant to chemotherapy in the treatment of these tumors.
c) use of biocompatible nanoparticles for the delivery of single drugs or combinations thereof. The nanoparticles may carry specific ligands for receptors over-expressed by tumor cells that increase the specificity of accumulation in tumor cells by exploiting active targeting mechanisms.

The methods of investigation are based on the use of 2D and 3D cultures of tumor cells and in vivo models of transplanted tumors in Zebrafish embryos. The effects of the treatments are evaluated by analysing the cells through cell viability/death assays and confocal microscopy analysis.

Curriculum Vitae
To see curriculum vitae download the pdf file

Lecturer's Curriculum (PDF): 7ECA0365261F0F2B2808E3A4967884E2.pdf

Research areas
Research themes have the common goal of identifying strategies to make anticancer therapies more effective and selective. The current approaches followed are based on:

1. Delivery of anticancer drugs using biocompatible nanoparticles. The delivery through nanostructures increases the selectivity of release of the drug in the tumor tissue by exploiting the particular characteristics of its vascularization.

2. Combinations of chemotherapeutics that exert cytotoxic action with different mechanisms of action. We identify conditions that result in a synergistic interaction between drugs because synergistic drug interaction allows to maintain the therapeutic efficacy by lowering drug doses and consequently the side effects of the therapy also counteracting the intrinsic or acquired drug resistance of many tumors. The study of the delivery of multiple drugs through appropriately designed nanostructures is a topic of particular interest to the research group.

3. Combinations of different therapeutic modalities. In particular, our attention is focused on the combination of chemotherapy and photodynamic therapy. Photodynamic therapy uses a photosensitizing drug and visible light to induce selective damage in tumor tissue by oxidative stress and is also effective in chemo-resistant tumors.

To see the list of published papers download the pdf document

Lecturer's Publications (PDF): 7ECA0365261F0F2B2808E3A4967884E2.pdf

List of taught course units in A.Y. 2019/20
Degree course code (?) Degree course track Course unit code Course unit name Credits Year Period Lang. Teacher in charge
SC1161 COMMON SC02100882 8 1st Year (2019/20) Second
SC1166 COMMON SCP5071886 9 2nd Year (2019/20) Second

Responsibility of other activity for A.Y. 2019/20
Degree course code (?) Degree course track Course unit code Course unit name Credits Year Period Lang. Teacher in charge
SC1178 COMMON SCP9087102 2 1st Year (2019/20) Annual ENG ELENA REDDI
SC1161 COMMON SCP8085538 3 1st Year (2019/20) Annual ENG ELENA REDDI