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Structure Department of Biology
Telephone 0498276208
Qualification Professore ordinario
Scientific sector BIO/13 - APPLIED BIOLOGY
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(updated on 14/06/2018 12:26)

Proposals for thesis
Studies of the molecular genetics and pathogenesis of inherited cardiomyopathies.
Please contact the teacher for specific information.

Curriculum Vitae
March 1991 Degree in Biological Sciences at the University of Padova
July 1997 PhD in Genetics at the University of Ferrara
December 2004 Post-graduate school in Medical Genetics at the University of Padova.

Academic appointments
December 2002 Assistant professor in Applied Biology at Department of Biology, University of Padova
October 2010 Associate professor in Applied Biology, at Department of Biology, University of Padova
October 2017 Full professor in Applied Biology, at Department of Biology, University of Padova

Teaching activities
Graduate Course in Health Biology and in Food Science and Technologies
PhD Course in Cardiosciences and Biosciences

Research fields
Molecular genetics of cardiomyopathies, with particular reference to Arrhythmogenic Cardiomyopathy (AC or ARVC), which is a common cause of juvenile sudden death among athletes.
Both biologist and medical genetist, working in the field of molecular genetics since 1992, she was involved in mapping four loci and in identifying five novel AC genes. These findings allowed the employment of mutation screening for carrier detection among family members of affected subjects and played an essential role in sudden death prevention and genetic counseling.
In the last years, she moved from molecular genetics studies to functional studies to unveil molecular mechanisms involved in the pathogenesis of inherited cardiomyopathies through generation of animal models.

Selected research achievements:
-1994 Mapping of the first AC locus
-2001 Identification of the gene involved in ARVD2 (RYR2 gene)
-2002 Mapping and identification of the gene involved in ARVD8 (DSP gene)
-2005 Identification of the gene involved in ARVD1 (TGFbeta3 gene)
-2006 Identification of the gene involved in ARVD10 (DSG2 gene)
-2012 Identification of a novel AC gene (CTNNA3 gene)


Research areas
The research activity is focused on the biological basis of inherited cardiomyopathies. To this aim we use various approaches, ranging from genetic and genomic analyses (experimental and computational alike) to the use of in vitro and in vivo models.
In particular, we study mutations and genomic variations involved in different inherited cardiomyopathies, both to identify novel disease genes and to elucidate their molecular pathogenesis. These studies are carried out with in silico genome-wide approaches, with in vitro cell culture models, and with in vivo murine disease models.


List of taught course units in A.Y. 2019/20
Degree course code (?) Degree course track Course unit code Course unit name Credits Year Period Lang. Teacher in charge
SC1177 COMMON SC01122943 9 1st Year (2019/20) Second
AG0057 COMMON AG04100865 8 1st Year (2019/20) First