CASTAGLIUOLO IGNAZIO

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Structure Department of Molecular Medicine
Telephone 0498272360
Qualification Professore associato confermato
Scientific sector MED/07 - MICROBIOLOGY AND CLINICAL MICROBIOLOGY
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Office hours
Monday from 09:00 to 18:00 Via Gabelli 63 - secondo piano Previo accordo telefonico o via mail con il docente
Tuesday from 09:00 to 18:00 Via Gabelli 63 - secondo piano Previo accordo telefonico o via mail con il docente
Wednesday from 09:00 to 18:00 Via Gabelli 63 - secondo piano Previo accordo telefonico o via mail con il docente
Thursday from 09:00 to 18:00 Via Gabelli 63 - secondo piano Previo accordo telefonico o via mail con il docente
(updated on 21/04/2018 08:32)

Proposals for thesis
1. Studio dell'interazione dell'Herpes virus tipo 1 con sistema nervoso enterico, utilizzando modelli murini e campioni di origine umana. Si approfondirà effetto infezione virale su ambiente immunitario nei gangli mienterici e lo sviluppo di linfociti esausti. Saranno ricercati marcatori molecolari di neurodegenerazione.

2. Studio di antagonisti del quorum sensing batterico come nuove strategie terapeutiche. In collaborazione con i colleghi Chimici farmaceutici verranno progettate e sintetitizzate nuove molecole in grado di interferire con i segnali del quorum sensing batterico e se ne valuterà effetto sia con saggi in vivo (formazione biofilm, espressione tossine e altri fattori di patogenicità) che in vitro (saggi di legame tra molecole quorum sensing e recettore batterico).

3. Analisi dei meccanismi di immuno-sorveglianza coinvolti nelle fasi precoci della carcinogenesi colica. Si utilizzeranno modelli murini e tessuti di origine umana. Verranno condotti studi su linee cellulari e su modelli di carcinognesi murina.

4. Studio di nuovi approcci terapeutici alla colite da Clostridium difficile. Saranno condotti test in vivo ed in vitro per verificare la capacità dei nuovi composti di legare le tossine e prevenire la colonizzazione da C. difficile.

Curriculum Vitae
Birth place and date: Naples (Italy), September 8th, 1961. Citizenship: Italian.
University degree: Medicine and Surgery, with honors, at the School of medicine and Surgery of the University of Naples (November 1987). Postgraduate education: Degree at the Postgraduate School of Internal Medicine, University of Naples (July 1992).
Current Academic position: Associate Professor of Microbiology, University of Padua (since December 2004).
Previous Academic positions: Research associate (1996, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston); Instructor in Medicine (1997-1998, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston); Assistant Professor in Medicine (1999, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston); Assistant Professor in Microbiology (1999-2004, University of Padua).
Teaching activity: School of Medicine University of Padua microbiology courses to undergraduate (Medicine, Pharmacy, Nurse school) and graduate (International Master of Perfumery and Business administration, PhD School in Molecular Medicine, Specialization schools in Medicine and Pharmacy) students.
Funding from American private institutions (Crohn's and Colitis foundation), italian public institutions (MIUR, Regione Veneto, University of Padua, Istituto Zooprofilattico delle Venezie), companies (IZO, Zeta farmaceutici, Fidia, Gnosis, AAT, Biocodex, Ajinomoto Co).
Main research topics: 1)role of enteric nervous system in intestinal homeostasis; 2) mechanism of enteric nerves damage mediated by neurotropic nerves; 3) cancer immune surveillance; 4) gut microbiota-host interplay; 5) bacterial quorum sensing as new therapeutic target.
Member of American Society of Microbiology, European Society of Virology, Italian society virology.
Published 142 full papers in international journals subjected to full review and quoted on JCR-ISI database; 42 total H-index (Scopus); 6133 citations (Scopus); 3 international patents.

Research areas
Principali settori di interesse scientifico:
1) ruolo del sistema nervoso enterico nella omeostasi intestinale;
2) meccanismi di danno ai nervi enterici da virus neurotropi;
3) meccanismi di immunosorveglianza nel cancro colico;
4) interazione tra microbiota intestinale ed ospite;
5) il quorum sensing batterico come un nuovo target terapeutico.

Publications
Castagliuolo I, et al. Neuronal involvement in the intestinal effects of C difficile toxin A and V. choleare enterotoxin. Gastroenterology 194;107:657
Castagliuolo I, et al. Increased substance P responses in dorsal root ganglia and intestinal macrophages during C.difficile toxin A enteritis in rats. Proc Natl Acad Sci (USA) 1997;94:4788
Brun P, et al. Exposure to bacterial cell wall products triggers an inflammatory phenotype in hepatic stellate cells. Am J Physiol Gastrointest Liver Physiol 2005;289:G571
Brun P, et al. Increased intestinal permeability in obese mice: new evidences in the pathogenesis of nonalcoholic steatohepatitis. Am J Physiol Gastrointest Liver Physiol 2007;292:G518
Facco M, et al. T cells in the myenteric plexus of achalasia patients show a skewed TCR repertoire and react to HSV-1 antigens. Am J Gastroenterol 2008;103:1598
Voltan S, et al. L. crispatus M247-derived H2O2 acts as a signal transducing molecule activating peroxisome proliferator activated receptor-gamma in the intestinal mucosa. Gastroenterology 2008;135:1216
Brun P, et al. HSV-1 Infection of the Rat Enteric Nervous System Evokes Small Bowel Neuromuscular Abnormalities. Gastroenterology 2010;138:1790
Scarpa M, et al. Relationship between mucosa-associated microbiota and inflammatory parameters in the ileal pouch after restorative proctocolectomy for ulcerative colitis. Surgery 2011;150:56
D'Incà R, et al. Rectal administration of L. casei DG modifies flora composition and Toll-like receptor expression in colonic mucosa of patients with mild ulcerative colitis. Dig Dis Sci 2011;56:1178
Scarpa M, et al. TLR2 and TLR4 up-regulation and colonization of the ileal mucosa by Clostridiaceae spp. in chronic/relapsing pouchitis. J Surg Res. 2011;169:e145-154
Scarpa M, et al. Innate immune environment in ileal pouch mucosa: α5 defensin up-regulation as predictor of chronic/relapsing pouchitis. J Gastrointest Surg 2012;16:188
Brun P, et al. Toll-like receptor 2 regulates intestinal inflammation by controlling integrity of the enteric nervous system. Gastroenterology 2013;145:1323
Zoppellaro C, et al. Adenosine-mediated enteric neuromuscular function is affected during herpes simplex virus type 1 infection of rat enteric nervous system. PLoS One 2013;8:e72648
Scarpa M, et al. CD80-CD28 signaling controls the progression of inflammatory colorectal carcinogenesis. Oncotarget 2015;6:20058
Brun P, et al. TLR-2 regulates production of glial-derived neurotrophic factors in murine intestinal smooth muscle cells. Mol Cell Neurosci 2015;68:24
Pathak S, et al. MiR-155 modulates the inflammatory phenotype of intestinal myofibroblasts by targeting SOCS1 in ulcerative colitis. Exp Mol Med 2015;47:e164
Grillo AR, et al. TAK1 is a key modulator of the profibrogenic phenotype of human ileal myofibroblasts in Crohn's disease. Am J Physiol Gastrointest Liver Physiol 2015;309:G443
Scarpa M, et al. Mismatch repair gene defects in sporadic colorectal cancer enhance immune surveillance. Oncotarget 2015;6:43472
Brun P, et al. S. boulardii CNCM I-745 supplementation reduces gastrointestinal dysfunction in an animal model of IBS. PLoS One 2017;12:e0181863
Scarpa M, et al. Immunonutrition before esophagectomy: Impact on immune surveillance mechanisms. Tumour Biol 2017;39:1010428317728683.
Brun P, et al. HSV-1 Infects Enteric Neurons and Triggers Gut Dysfunction via Macrophage Recruitment. Front Cell Infect Microbiol 2018 Mar 15;8:74. doi: 10.3389/fcimb.2018.00074

List of taught course units in A.Y. 2019/20
Degree course code (?) Degree course track Course unit code Course unit name Credits Year Period Lang. Teacher in charge
ME1844 999FE MEP4063586 6 1st Year (2019/20) Second
semester
ITA
ME1727 COMMON MEP5071108   ITA EDOARDO VINCENZO SAVARINO
»   MEP5071109 4 4th Year (2019/20) Second
semester
ITA EDOARDO VINCENZO SAVARINO
»   MEP5071109 4 4th Year (2019/20) Second
semester
ITA EDOARDO VINCENZO SAVARINO
»   MEP5071110 4 4th Year (2019/20) Second
semester
ITA SAVERIO PARISI
»   MEP5071110 4 4th Year (2019/20) Second
semester
ITA SAVERIO PARISI
FA1732 COMMON MEP8083117 8 2nd Year (2019/20) Second
semester
ITA IGNAZIO CASTAGLIUOLO
ME1726 COMMON MEP5071038 11 2nd Year (2019/20) Second
semester
ITA GUALTIERO ALVISI