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Structure Department of Chemical Sciences
Telephone 0498275279
Qualification Professore associato confermato
Scientific sector CHIM/06 - ORGANIC CHEMISTRY
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Office hours
Tuesday from 14:30 to 16:00 Dipartimento di Scienze Chimiche, Via Marzolo 1 Su appuntamento
(updated on 26/04/2018 15:23)

Proposals for thesis
Nuclear Magnetic Resonance (NMR) is a powerful tool for the detection and the analysis of organic compounds in solution. The main advantage of this technique lies in its capability to provide information useful for the structure determination of unknown compounds. Despite this appealing characteristic, the following drawbacks are often encountered in NMR:

• (very) low sensitivity compared to other spectroscopic techniques
• long acquisition times
• high complexity of the spectrum

While the long acquisition times and the sensitivity issues can be quite improved with proper modifications in the pulse sequences, the complexity of the NMR signal is an intrinsic feature of the technique. As such, especially in <sup>1</sup>H NMR, it is very common to find overlapped signals in a sample containing two or more analytes, compromising the correct identification of the species. Two-dimensional spectroscopic techniques can partly solve the spectral crowding issues, but the assignment of overlapped signals to the respective species can still be a challenging task, especially for complex mixtures.

Curriculum Vitae
Born some time ago, Federico Rastrelli (FR) graduated in Chemistry in year 2000 and spent one year working at the Area Science Park in Trieste. He received his Ph.D. in Chemistry in 2005 and became Assistant Professor in 2006 at the Department of Chemical Sciences of Padova University. He has been a Visiting Scientist at the <I>National Institute of Advanced Industrial Science and Technology</I> in Tsukuba (Japan) and at the <I>Ecole Normale Supérieure</I> in Lyon (France). Since March 2018 he is Associate Professor at the University of Padua and a member of the Department of Chemical Sciences.

FR’s research interests have always been focused on magnetic spectroscopies, particularly on NMR methods in organic chemistry and on the determination of NMR parameters in diamagnetic and paramagnetic species by DFT calculations. FR has also been working on the development of NMR methods for food chemistry and, since 2010, his research is mainly focused on NMR spectroscopy of nanosystems in solution.

FR actively collaborates with Italian and foreign research groups, including those of Marco DeVivo (IIT Genova), Giovanni Appendino (Univ. Piemonte Orientale), Luca Prodi (Univ. Of Bologna), Enrico Dalcanale, (Univ. Parma), Malcolm H Levitt (Southampton University).

FR is a teacher in BSc and MSc degrees in Chemistry, Industrial Chemistry, Biology, and in the PhD School in Molecular Sciences. Since 2017 he is a member of the examining committee for the admission to the class of Natural Sciences at the Galileian School of Higher Education.

He is co-author of 1 patent and 49 papers published in international journals.

Research areas
NMR methodologies in Organic Chemistry
DFT calculations of NMR parameters for small diamagnetic and paramagnetic molecules
Matrix-assisted NMR
NMR of nanosystems
Solid-state NMR

Food Chemistry: NMR characterization of oxidation products resulting from thermal stress of vegetable oils. NMR of honey.

ORCID: http://orcid.org/0000-0002-2369-2228

Schievano, E., Tonoli, M., Rastrelli, F.
NMR Quantification of Carbohydrates in Complex Mixtures. A Challenge on Honey
(2017) Analytical Chemistry, 89 (24), pp. 13405-13414.
DOI: 10.1021/acs.analchem.7b03656

Riccardi, L., Gabrielli, L., Sun, X., De Biasi, F., Rastrelli, F., Mancin, F., De Vivo, M.
Nanoparticle-Based Receptors Mimic Protein-Ligand Recognition
(2017) Chem, 3 (1), pp. 92-109.
DOI: 10.1016/j.chempr.2017.05.016

Casella, G., Causin, V., Rastrelli, F., Saielli, G.
Ionic liquid crystals based on viologen dimers: tuning the mesomorphism by varying the conformational freedom of the ionic layer
(2016) Liquid Crystals, 43 (9), pp. 1161-1173.
DOI: 10.1080/02678292.2016.1161852

González-García, T., Margola, T., Silvagni, A., Mancin, F., Rastrelli, F.
Chromatographic NMR Spectroscopy with Hollow Silica Spheres
(2016) Angewandte Chemie - International Edition, 55 (8), pp. 2733-2737.
DOI: 10.1002/anie.201510203

Rastrelli, F., Bagno, A., Appendino, G., Minassi, A.
Bioactive Phloroglucinyl Heterodimers: The Tautomeric and Rotameric Equilibria of Arzanol
(2016) European Journal of Organic Chemistry, 2016 (28), pp. 4810-4816.
DOI: 10.1002/ejoc.201600597

Diez-Castellnou, M., Salvia, M.-V., Springhetti, S., Rastrelli, F., Mancin, F.
Nanoparticle-Assisted Affinity NMR Spectroscopy: High Sensitivity Detection and Identification of Organic Molecules
(2016) Chemistry - A European Journal, 22 (47), pp. 16957-16963.
DOI: 10.1002/chem.201603578

Salvia, M.-V., Salassa, G., Rastrelli, F., Mancin, F.
Turning Supramolecular Receptors into Chemosensors by Nanoparticle-Assisted "nMR Chemosensing"
(2015) Journal of the American Chemical Society, 137 (35), pp. 11399-11406.
DOI: 10.1021/jacs.5b06300

Borgogno, A., Rastrelli, F., Bagno, A.
Characterization of Paramagnetic Reactive Intermediates: Predicting the NMR Spectra of Iron(IV)-Oxo Complexes by DFT
(2015) Chemistry - A European Journal, 21 (37), pp. 12960-12970.
DOI: 10.1002/chem.201500864

Piserchia, A., Zerbetto, M., Salvia, M.-V., Salassa, G., Gabrielli, L., Mancin, F., Rastrelli, F., Frezzato, D.
Conformational Mobility in Monolayer-Protected Nanoparticles: From Torsional Free Energy Profiles to NMR Relaxation
(2015) Journal of Physical Chemistry C, 119 (34), pp. 20100-20110.
DOI: 10.1021/acs.jpcc.5b04884

Prodi, L., Rampazzo, E., Rastrelli, F., Speghini, A., Zaccheroni, N.
Imaging agents based on lanthanide doped nanoparticles
(2015) Chemical Society Reviews, 44 (14), pp. 4922-4952.
DOI: 10.1039/c4cs00394b

Salvia, M.-V., Ramadori, F., Springhetti, S., Diez-Castellnou, M., Perrone, B., Rastrelli, F., Mancin, F.
Nanoparticle-assisted NMR detection of organic anions: From chemosensing to chromatography
(2015) Journal of the American Chemical Society, 137 (2), pp. 886-892.
DOI: 10.1021/ja511205e

Masseroni, D., Rampazzo, E., Rastrelli, F., Orsi, D., Ricci, L., Ruggeri, G., Dalcanale, E.
pH-responsive host-guest polymerization and blending
(2015) RSC Advances, 5 (15), pp. 11334-11342.

Lecturer's Publications (PDF): 588CB7D4F8EFC7CFD09936E48BDA87F9.pdf

List of taught course units in A.Y. 2019/20
Degree course code (?) Degree course track Course unit code Course unit name Credits Year Period Lang. Teacher in charge
SC1177 COMMON SCL1000651 8 2nd Year (2019/20) First
FA1732 COMMON FA04101354 10 1st Year (2019/20) Second
SC1170 COMMON SCL1001867 6 2nd Year (2019/20) First