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Structure Department of Biology
Telephone 0498276244
Qualification Professore associato confermato
Scientific sector BIO/09 - PHYSIOLOGY
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Proposals for thesis
1. Role of the Parkinson’s disease kinase LRRK2 in shaping neurites and synapses
2. Neuronal signalling associated with the kinase PAK6
3. Role of 14-3-3 proteins in the neuronal regulation of TFEB, the master coordinator of autophagy and lysosome biogenesis
4. Role of SPG11, a protein mutated in Hereditary Spastic Paraplegia, in the autophagy-lysosomal pathway
5. Regulation of GBA activity, subcellular localization and lysosomal function by LRRK2

Curriculum Vitae
A. Positions and honors

Positions and employment
2014-present: Associate Professor of Physiology, Department of Biology, University of Padua, Italy
2009-2014: Assistant Professor ‘Rientro dei Cervelli’, Department of Biology, University of Padua, Italy
2005-2009: Postdoctoral research fellow, Laboratory of Neurogenetics, NIA, NIH, Bethesda, MD, USA
2002-2005: Ph.D. student in Molecular Physiology and Structural Biology, University of Padua, Italy

Other experience and Professional Memberships
2006-present: Member Society for Neuroscience (SfN)
2011-present: Member Italian Society of Physiology
2011-present: Editorial board member of PLoS ONE
2015-present: Editorial board member of Journal of Neurochemistry

Prizes, Awards, Fellowships
2015 Milla Baldo Ceolin Award, best woman researcher of the year at University of Padova
2009 National Institute of Health - Nathan W. Shock Award
2009 Paolo Guidetti Award
2009 Brain Gain (Rientro dei Cervelli) award
2006 National Institute of Health NIH-FARE - Award for Research Excellence
2005-2009 National Institute of Health postdoctoral fellowship

B. Scientific activity

Elisa Greggio is author of 57 papers (12 as first, 12 as last and 20 as corresponding author) in peer-reviewed international journals.
h-index 23 (scopus)
Total citations: 2627 (scopus)

Invited seminars at international centers of excellence
06/2006 NIH, Bethesda, Maryland, USA
03/2007 Department of Biology, University of Padova, Padova, Italy.
04/2009 Department of Biology, University of Padova, Padova, Italy.
04/2010 Institute of Neurology, UCL, London, UK
10/2010 Parkinson Institute, Milano, Italy
04/2011 Istituto di Neuroscienze CNR, Milano, Italy
11/2011 University of Ferrara, Ferrara, Italy
06/2012 Department of Chemistry, KU Leuven, Leuven, Belgium
03/2013 Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland
07/2013 University of Sassari, Sassari, Italy
05/2014 University College London, Institute of Neurology, London, UK
10/2017 VUB, Brussels, Belgium

Invited presentations at international conferences
01/2010 Protein Phosphorylation and Neurodegenerative Diseases, Valencia, Spain.
03/2012 LRRK2 Function & Dysfunction, Biochemical Society Conference, London, UK
04/2018 PHysiopathology Of Parkinson’s disEase (HOPE), Lille, France
09/2018 Biennial International LRRK2 Meeting, Padova, Italy

Organization of scientific meetings
2016 - Biochemical Society Focused Meeting “Leucine-Rich Repeat Kinase 2: ten years along the road to therapeutic intervention”, Henley Business School, Greenlands, UK
2018 - Biochemical Society Focused Meeting "Biennial International LRRK2 Meeting", Orto Botanico, Padova, Italy

C. Research Support and supervision

Over the past 10 years, I obtained funding from national and international agencies (Italian Ministry of Research, Telethon Foundation, Cariplo Foundation, Michael J Fox Foundation) raising more than 2.5 million euros. In addition, I trained 5 post-doctoral fellows (with two of them currently holding an Assistant Professor position) and more than 20 master and PhD students.

Lecturer's Curriculum (PDF): 4896844BE78592024126E807E77926C0.pdf

Research areas
My laboratory is interested in studying the molecular mechanisms underlying the early events of neurodegeneration associated with Parkinson’s disease. We are particularly focused on the pathophysiology of the kinase LRRK2, which mutations represent the single most common cause of familial Parkinson’s disease, on glucocerebrosidase (GBA), a lysosomal enzyme that mutated represents the most important risk factor for Parkinson's disease, and on SPG11, a lysosomal protein mutated in a familial form of Hereditary Spastic Paraplegia with parkinsonism. We combine cellular and animal models to investigate the signaling pathways and the pathological consequences of gene mutations on neuronal and glial cells homeostasis.

List of taught course units in A.Y. 2019/20
Degree course code (?) Degree course track Course unit code Course unit name Credits Year Period Lang. Teacher in charge
SC1179 COMMON SCP8084977 6 1st Year (2019/20) First
IF1839 COMMON SCO2045386 12 2nd Year (2019/20) First
SC1165 COMMON SCP4068159   ITA
»   SCP4068161 9 3rd Year (2019/20) First
»   SCP4068160 7 3rd Year (2019/20) First