ZORDAN MAURO AGOSTINO

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Structure Department of Biology
Telephone 0498276211
Qualification Professore associato confermato
Scientific sector BIO/18 - GENETICS
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Office hours
Studio, Secondo Piano Sud (lato ricerca) Complesso Biologico Vallisneri E' possibile concordare appuntamenti liberamente contattando il docente per email: mauroagostino.zordan@unipd.it
(updated on 27/04/2018 10:50)

Proposals for thesis
Currently, my main interest rests in the use of Drosophila as a model of neuropsychiatric disease.Flies allow experimental approaches which are still difficult to address in other vertebrate model organisms, with particular reference to the sophisticated genetics and a very powerful toolbox of transgenic methods for neuronal circuit analysis. In addition, Drosophila has a relatively complex nervous system which shares many fundamental cellular and neurobiological processes with humans.
Altogether the common denominator of my ongoing research activity entails the use of Drosophila melanogaster as a model to study the genetics of behavioural, neuromuscular and synaptic defects which have some relation to known human hereditary diseases.
The subject proposed for thesis work will revolve around the study of different aspects of behaviour in Drosophila, such as: sleep/wake rhtyms; locomotor activityin single individuals and/or groups of flies; attention/eccitability; learning and memory.

Curriculum Vitae
Present position
Associate Professor in Genetics in the School of Science, Department of Biology, University of Padova, Italy; Teaching activity: Genetics, Population Genetics and, Molecular Phylogenetics; Responsible for the ERASMUS International Student Exhange program for the Department of Biology, and within this framework I am actively involved in maintaining a Double Diploma program between our University and the University of Paris VII (France), for the Master's degree in Molecular Biology and the Master's degree in Genetics (Magistére en Génétique), respectively.

Major research interests
• I have been involved in research aimed at understanding the adaptive meaning of the molecular machinery implicated in the generation and maintenance of biological circadian rhythms in Drosophila melanogaster as well as other insects. In this context I developed most of my experience in conducting behavioural analyses with the objective of establishing the presence of locomotor defects as well as alterations in integrative neuronal functions such as those involved in the response to visual and/or olfactory stimuli.
• I have participated in research in which Drosophila melanogaster was used as a model for the study of genes involved in human hereditary neuromuscular and/or mitochondrial diseases.
• I have been involved in a collaborative research project in which the Drosophila larval neuromuscular junction was used as a model chemical synapse (glutamatergic) in which to study the detailed interplay between proteins and membrane lipids (among which the sphingolipids) in the process of neuronal vesicle recycling.
• Currently, my main interest rests in the use of Drosophila as a model of neuropsychiatric disease. The complex constellation of behavioural phenotypes involved in neuropsychiatric disorders and the largely familiar pattern of inheritance, which is of a complex genetic nature, are the main reasons why so little is known of the pathogenesis of these diseases. Flies allow experimental approaches which are still difficult to address in other vertebrate model organisms, with particular reference to the sophisticated genetics and a very powerful toolbox of transgenic methods for neuronal circuit analysis. In addition, Drosophila has a relatively complex nervous system which shares many fundamental cellular and neurobiological processes with humans.
Altogether the common denominator of my ongoing research activity entails the use of Drosophila melanogaster as a model to study the genetics of behavioural, neuromuscular and synaptic defects which have some relation to known human hereditary diseases.

Research areas
Studies having as their main focus the neurogenetics of behaviour using the model organism Drosophila melanogaster. The behavioural aspects of interest essentially include cognitive/motor aspects of the processes involved in decision-making; learning and memory; attention/eccitability.

Publications
Bosco G., Clamer M., Messulam E., Da Re C., Yang Z., Zordan M., Reggiani C., Hu Q., Megighian A. (2015) Effects of oxygen concentration and pressure on Drosophila melanogaster: oxidative stress, mitochondrial activity, and survivorship. Arch Insect Biochem Physiol. 88(4):222-34. doi: 10.1002/arch.21217.

Da-Rè C, von Stockum S, Biscontin A, Millino C, Cisotto P, Zordan MA, Zeviani M, Bernardi P, De Pittà C, Costa R. (2014) Leigh syndrome in Drosophila melanogaster: morphological and biochemical characterization of Surf1 post-transcriptional silencing. J Biol Chem. 289(42):29235-46.

Da-Rè C, Franzolin E, Biscontin A, Piazzesi A, Pacchioni B, Gagliani MC, Mazzotta G, Tacchetti C, Zordan MA, Zeviani M, Bernardi P, Bianchi V, De Pittà C, Costa R. (2014). Functional characterization of drim2, the Drosophila melanogaster homolog of the yeast mitochondrial deoxynucleotide transporter. J Biol Chem. 289(11):7448-59.

Da-Ré C, De Pittà C, Zordan MA, Teza G, Nestola F, Zeviani M, Costa R, Bernardi P. (2014). UCP4C mediates uncoupled respiration in larvae of Drosophila melanogaster. EMBO Rep. 15(5):586-91.

Megighian A., Zordan M., Pantano S., Scorzeto M., Rigoni M., Zanini D., Rossetto O., Montecucco C. (2013). Evidence for a radial SNARE super-complex mediating neurotransmitter release at the Drosophila neuromuscular junction. J Cell Sci. 126: 3134-40.

List of taught course units in A.Y. 2018/19
Degree course code (?) Degree course track Course unit code Course unit name Credits Year Period Lang. Teacher in charge
SC1179 COMMON SCP8084940 6 1st Year First
semester
ITA ALESSANDRA ROSALBA BRAZZALE
SC1165 COMMON SCP3053524 10 3rd Year Second
semester
ENG ANDREA AUGUSTO PILASTRO
SC1175 COMMON SCL1000227 4 2nd Year First
semester
ENG MAURO AGOSTINO ZORDAN
SC1165 COMMON SCP4068094     ITA MAURO AGOSTINO ZORDAN
»   SCP4068095 7 2nd Year First
semester
ITA MAURO AGOSTINO ZORDAN
»   SCP4068096 7 2nd Year First
semester
ITA MARIA EUGENIA SORIANO GARCIA - CUERVA


Responsibility of other activity for A.Y. 2018/19
Degree course code (?) Degree course track Course unit code Course unit name Credits Year Period Lang. Teacher in charge
SC1165 COMMON SC14105165 3 1st Year Annual ENG MAURO AGOSTINO ZORDAN
SC1166 COMMON SC14105165 3 1st Year Annual ENG MAURO AGOSTINO ZORDAN
SC2445 COMMON SCP8085064 2 1st Year Annual ENG MAURO AGOSTINO ZORDAN