MARIN ORIANO

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Structure Department of Biomedical Sciences
Telephone 0498276151
Qualification Professore associato confermato
Scientific sector BIO/10 - BIOCHEMISTRY
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Curriculum Vitae
1. Academic Qualifications:
Graduated in Biological Sciences (University of Padua), discussing the experimental thesis “Synthesis of peptides containing acidic cluster as substrates and inhibitor
of a c-AMP independent liver protein kinase”, reaching 110/110 cum laude. In the Academic years 1988-93 he made his PhD-Course in "Biology Molecular And
Cellular Pathology" at the University of Padua working to a thesis with the title: “Synthesis and Characterization of peptides to study protein kinase”. In the year 1992,
prof. Marin has been named in the role of the University Researchers, for the grouping discipline BIO/10 (Biochemistry) at the Faculty of Medicine and Surgery.
Since 2006 he is Associate Professor of Biochemistry at the School of Medicine and Surgery, University of Padua.
The scientific production of Prof. Marin consists of more than 130 papers (Section 3 - Research topics and Bibliometrics).

2. Core Competency:
He has gotten specific competences in the field of the protein and peptide chemistry, purification of proteins and antibodies production. Prof. Marin has devoted to the
planning of peptide libraries in the laboratory of Prof. Ronald Frank to the Centre of Biotechnologies GBF (Germany) for studying substrate specificity in protein
phosphorylation.
Prof. Marin develops his institutional assignments of research at the CRIBI Biothechnology Centre (University of Padua) where coordinates the activity of a research
group constituted firmly by a graduated technician and a PhD student. Further, Prof. Marin manages the Peptide Facility at CRIBI (http://peptidefacility.bio.unipd.it/)
with a mission to supply synthetic peptide for medical and biological research. At the same time, Prof. Marin has actively participated at proteomic project of
University of Padua and currently coordinates the research and proteomic server activities of the core facility for proteomic at Azienda Ospedaliera di Padova.

3. Research topics and Bibliometrics:
3.1 Protein phosphorylation and human disease . The most common cause of cystic fibrosis is the deletion of phenylalanine- 508 in the first nucleotide-binding
domain in the cystic fibrosis transmembrane conductance regulator (CFTR). How this hereditary defect affects the phosphorylation of CFTR and which signaling
pathways are involved in the process are open questions addressed by our research.
3.2 Antimicrobial peptides (AMPs ). Present research is focused on the synthesis , folding and structural characterization of a new AMP, known as Myticin C,
identified from the analysis of the transcriptome in Mytilus galloprovinciali.
3.3 Nanomedicine. Functionalization of nanoparticles with selective peptides for recognition of biological markers for early diagnosis of esophageal adenocarcinoma
of the colon and rectum.
3.4 Proteomics . Mass spectrometry of protein and peptides.
In complex the scientific production of Prof. Marin Oriano consists of more than 159 papers ( IF= 507,943 Web of Science Citation Report, H-index = 33)published in
the most important international magazines of biochemistry.

4. Memberships:
4.1 Centro interdipartimentale per le Biotecnologie Innovative dell'Università di Padova (CRIBI)
4.2 Istituto Veneto di Medicina Molecolare (VIMM) di Padova.
4.3 Centro di Proteomica, Università di Padova, Azienda Ospedaliera e VIMM.
4.4 Italian Society of Biochemistry and Molecular Biology (SIB).
4.5 Italian Proteomic Association (ItPA)

Publications
1 - Vicario, Mattia, Zanni, Ginevra, Vallese, Francesca, Santorelli, Filippo, Grinzato, Alessandro, Cieri, Domenico, Berto, Paola, Frizzarin, Martina, Lopreiato, Raffaele, Zonta, Francesco, Ferro, Stefania, Sandre, Michele, Marin, Oriano, Ruzzene, Maria, Bertini, Enrico, Zanotti, Giuseppe, Brini, Marisa, Calì, Tito, Carafoli, Ernesto (2018). A V1143F mutation in the neuronal-enriched isoform 2 of the PMCA pump is linked with ataxia. NEUROBIOLOGY OF DISEASE, ISSN: 0969-9961, doi: 10.1016/j.nbd.2018.04.009

2 - Jordi Vilardell, Cristina Girardi, Oriano Marin, Giorgio Cozza, Lorenzo A. Pinna, Maria Ruzzene (2018). The importance of negative determinants as modulators of CK2 targeting. The lesson of Akt2 S131. PLOS ONE, p. ..., ISSN: 1932-6203.

3- Carrer, Andrea, Leparulo, Alessandro, Crispino, Giulia, Ciubotaru, Catalin Dacian, Marin, Oriano, Zonta, Francesco, Bortolozzi, Mario (2018). Cx32 hemichannel opening by cytosolic Ca2+is inhibited by the R220X mutation that causes Charcot-Marie-Tooth disease. HUMAN MOLECULAR GENETICS, vol. 27, p. 80-94, ISSN: 0964-6906, doi: 10.1093/hmg/ddx386.

4 -Tonolo, F., Sandre, M., Ferro, S., Folda, A., Scalcon, V., Scutari, G., Feller, E., Marin, O., Bindoli, A., Rigobello, M. P. (2018). Milk-derived bioactive peptides protect against oxidative stress in a Caco-2 cell model. Food & Function, ISSN: 2042-6496, doi: 10.1039/C7FO01646H.

5 - Turrini Riccardo, Merlo Anna, Martorelli Debora, Faè Damiana Antonia, Sommaggio Roberta, Montagner Isabella Monia, Barbieri Vito, Marin Oriano, Zanovello Paola, Dolcetti Riccardo, Rosato Antonio (2017). A BARF1-specific mAb as a new immunotherapeutic tool for the management of EBV-related tumors. Oncoimmunology, vol. 6, e1304338, ISSN: 2162-4011, doi: 10.1080/2162402X.2017.1304338.

6 - Cali', Tito, Frizzarin, Martina, Luoni, L, Zonta, Francesco, Pantano, S, Cruz, C, Bonza, Mc, Bertipaglia, Ilenia, Ruzzene, Maria, De Michelis, Mi, Damiano, Nunzio, Marin, Oriano, Zanni, G, Zanotti, Giuseppe, Brini, Marisa, Lopreiato, Raffaele, Carafoli, Ernesto (2017). The ataxia related G1107D mutation of the plasma membrane Ca2+ ATPase isoform 3 affects its interplay with calmodulin and the autoinhibition process.. Biochimica et Biophysica Acta. Molecular Basis ff Disease, vol. 1863, p. 165-173, ISSN: 0925-4439, doi: 10.1016/j.bbadis.2016.09.007.

7 - Ottaviani, D, Marin, O, Arrigoni, G, Franchin, C, Vilardell, J, Sandre, M, Li, Wenwen, P, David A, Pinna, LA, Cheetham, ME, Ruzzene, M (2017). Protein kinase CK2 modulates HSJ1 function through phosphorylation of the UIM2 domain. Human Molecular Genetics, vol. 26, p. 611-623, ISSN: 0964-6906, doi: 10.1093/hmg/ddw420.

8 - Busatto, N, Salvagnin, U, Resentini, F, Quaresimin, S, Navazio, L, Marin, O, Pellegrini, M, Costa, F, Mierke, Dale F., Trainotti, L (2017). The Peach RGF/GLV Signaling Peptide pCTG134 Is Involved in a Regulatory Circuit That Sustains Auxin and Ethylene Actions. FRONTIERS IN PLANT SCIENCE, vol. 8, 1711, ISSN: 1664-462X, doi: 10.3389/fpls.2017.01711.

9 - Salvalaio M, Rigon L, Belletti D, D'Avanzo F, Pederzoli F, Ruozi B, Marin O, Vandelli Ma, Forni F, Scarpa M, Tomanin R, Tosi G (2016). Targeted Polymeric Nanoparticles for Brain Delivery of High Molecular Weight Molecules in Lysosomal Storage Disorders. PLOS ONE, vol. 11, ISSN: 1932-6203, doi: 10.1371/journal.pone.0156452.

List of taught course units in A.Y. 2019/20
Degree course code (?) Degree course track Course unit code Course unit name Credits Year Period Lang. Teacher in charge
ME1726 COMMON MEP5072539 8 1st Year First
semester
ITA ORIANO MARIN
ME1844 999PD MEP4065482 10 1st Year Annual ITA ORIANO MARIN