CHIARA FEDERICA

Contacts
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Structure Department of Cardiac, Thoracic and Vascular Sciences
Telephone 0498211371
Qualification Ricercatore universitario confermato
Scientific sector MED/44 - OCCUPATIONAL MEDICINE
University telephone book  Show
 

Office hours
Thursday from 10:00 to 11:00 Medicina del Lavoro. Ospedale Giustinianeo
(updated on 25/02/2014 11:41)

Proposals for thesis
Studio dei meccanismi cellulari alla base della tossicità di varie sostanze, con particolare attenzione ai chemoterapici.

Studio dei meccanismi molecolari che sostengono la tumorigenesi in pazienti affetti da Neurofrimomatosi di tipo 1.

Tesi di Medicina del Lavoro.

Research areas
- Studio dei meccanismi cellulari di tossicità dei chemoterapici di nuova generazione.
- Studio delle basi molecolari alla base dell'insorgenza dei tumori in bambini affetti da Neurofibromatosi di Tipo 1. FINANZIATO
- Ricerca di nuovi saggi di tossicità cellulare alternativi ai saggi in vivo.FINANZIATO

Publications
CHIARA F, BARTOLUCCI GB, CATTAI A, NICOLLI A, BUJA A, TREVISAN A
Hepatitis B vaccination of adolescents: significance of non-protective antibodies. VACCINE, Elsevier
CHIARA F,, RASOLA A (2013). GSK-3 and mitochondria in cancer cells. FRONTIERS IN ONCOLOGY, vol. 3, p. 1-6, ISSN: 2234-943X, doi: 10.3389/fonc.2013.00016
CHIARA F, BARTOLUCCI GB, MONGILLO M, FERRETTO L, NICOLLI A TREVISAN A. (2013). Hepatitis B vaccination at three months of age: a successful strategy?. VACCINE, vol. 31, p. 1696-1700, ISSN: 0264-410X, doi: 10.1016/j.vaccine.2013.01.046
CHIARA F., GAMBALUNGA A., SCIACOVELLI M., NICOLLI A., RONCONI L., FREGONA D., RASOLA A., TREVISAN A. (2012). Chemotherapeutic induction of mitochondrial oxidative stress activates GSK-3α/β and Bax, leading to permeability transition pore opening and tumor cell death CELL DEATH & DISEASE - LONDON, ENGLAND: NATURE PUBLISHING GROUP, - London,United Kingdom: Macmillan Magazines Limited -[Baltimore, Md.] : Williams & Wilkins, [c1987] Chief editors: Gerry Melino, Pierluigi Nicotera, Guido Kreumer
Impact Factor: 5.3 (ISI, 2012)
CHIARA F., CASTELLARO D, MARIN O, PETRONILLI V, BRUSILOW W.S, JUHASZOVA M, SOLLOTT S.J, FORTE M, BERNARDI P. AND ANDREA RASOLA (2008). Hexokinase II Detachment from Mitochondria Triggers Apoptosis through the Permeability Transition Pore Independent of Voltage-Dependent Anion Channels. PLOS ONE, ISSN: 1932-6203
LEMBO-FAZIO L, NIGRO G, NOEL G, ROSSI G, CHIARA F., TSILINGIRI K, RESCINIO M, RASOLA A. AND BERNARDINI ML (2010). Gadd45α activity is the principal effector of Shigella mitochondria-dependent epithelial cell death in vitro and ex vivo. CELL DEATH & DISEASE. London,United Kingdom: Macmillan Magazines Limited -[Baltimore, Md.] : Williams & Wilkins, [c1987] Chief editors: Gerry Melino, Pierluigi Nicotera, Guido Kreumer
MARZANO C, RONCONI L, CHIARA F., GIRON MC, FAUSTINELLI I, CRISTOFORI P, TREVISAN A, FREGONA D (2010). Gold(III)-dithiocarbamato anticancer agents: Activity, toxicology and histopathological studies in rodents. INTERNATIONAL JOURNAL OF CANCER, ISSN: 0020-7136, doi: 10.1002/ijc.25684
MONGILLO M, CHIARA F., RANZATO M, TREVISAN A (2010). Strategy for hepatitis A seroprevalence survey in a population of young people. VACCINE, vol. 28; p. 6985-6988, ISSN: 0264-410X, doi: 10.1016/j.vaccine.2010.08.044
RASOLA A, SCIACOVELLI M, CHIARA F.*, PANTIC B, BRUSILOW WS, BERNARDI P (2010). Activation of mitochondrial ERK protects cancer cells from death through inhibition of the permeability transition. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 107; p. 726-731, ISSN: 0027-8424, doi: 10.1073/pnas.0912742107
* second author
MARTIN M, TROVÒ L, PERGA S, SADOWSKAA A, RASOLA A, CHIARA F*. and CARLOS DOTTI (2009). Cyp46-mediated cholesterol loss promotes survival in stressed hippocampal neurons. NEUROBIOLOGY OF AGING, ISSN: 0197-4580, doi: 10.1016
*Chiara F. directed the the project
CHIARA F., BISHAYEE S, HELDIN CH, DEMOULIN JB (2004). Autoinhibition of the platelet-derived growth factor beta-receptor tyrosine kinase by its C-terminal tail. THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 279; p. 19732-19738, ISSN: 0021-9258
CHIARA F., GOUMANS MJ, FORSBERG H, AHGREN A, RASOLA A, ASPENSTROM P, WERNSTEDT C, HELLBERG C, HELDIN CH, HEUCHEL R (2004). A gain of function mutation in the activation loop of platelet-derived growth factor beta-receptor deregulates its kinase activity. THE JOURNAL OF

List of taught course units in A.Y. 2018/19
Degree course code (?) Degree course track Course unit code Course unit name Credits Year Period Lang. Teacher in charge
ME1861 COMMON MEP3053090 8 2nd Year First
semester
ITA VINCENZO BALDO
ME1869 COMMON MEP3056464 7 1st Year Second
semester
ITA MANUEL ZORZI
ME1933 COMMON MEO2044818 8 1st Year Second
semester
ITA SOFIA PAVANELLO