MARTELLO GRAZIANO

Contacts
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3549b9f5e9c263b85a6329e954fe19fe
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Structure Department of Molecular Medicine
Telephone 0498276088
Qualification Professore associato confermato
Scientific sector BIO/17 - HISTOLOGY
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Curriculum Vitae
PERSONAL INFORMATION
Martello Graziano
Researcher unique identifier: orcid.org/0000-0001-5520-085X
Date of birth: 01/04/1980
Nationality: Italian


• EDUCATION

03/2009 PhD in Genetics and developmental biology
Thesis title: “MicroRNAs involved in embryonic development and tumour progression”
Department of Histology Microbiology and Medical Biotechnologies, University of Padua, Italy - Prof. Stefano Piccolo
03/2005 Master Degreee in Medical Biotechnologies
Thesis title: “Isolation of a Ubiquitin ligase for Smad4: its role in germ layers formation and cell proliferation, University of Padua, Italy


• POSITIONS

08/2017 – Present Associate Professor of Histology
03/2014 – Present Telethon Scientist
03/2014 – 07/2017 Assistant Professor of Molecular Biology
Department of Molecular Medicine - Medical School of Padua University, Italy

04/2010 – 02/2014 Research Associate
Project on the mechanisms controlling pluripotency in mouse ES cells (Prof. Austin Smith)
Wellcome Trust – Medical Research Council Centre for Stem Cell Research, University of Cambridge, UK

01/2009 – 03/2010 Post-Doc - Project on microRNA controlling TGF-beta signalling (Prof. Stefano Piccolo)
Department of Histology Microbiology and Medical Biotechnologies, University of Padua, Italy


• FELLOWSHIPS

01/2011 – 12/2013 HFSP (Human Frontieres Science Program) fellowship
01/2009 – 03/2010 microRNA in cancer, AIRC (Italian Association for Cancer Research), Department of Histology Microbiology and Medical Biotechnologies, University of Padua, Italy


• HONOURS AND PRIZES
2008 - “Concorso giovani ricercatori 2007” (Young researchers award 2007), for young Italian researchers .
2010 - “Cecila Cioffrese” prize from the Carlo Erba Foundation.
2012 - “Young Venetian Excellence Award 2012” in the field of Life sciences.
2013 - "Armenise-Harvard Career Development Award and Telethon Foundation Career Award (1,000,000 dollars , 5 years)
2013 – Telethon DTI Career Development award (600,000 euros, 5 years)
2016 – Europen Research Council (ERC) Starting Grant (1,500,000 euros, 5 years)

ORAL PRESENTATIONS – INVITED SPEAKER

June 21st 2018 – Rome (Italy) SIBBM Frontier in Molecular Biology
Title: A common molecular logic determines pluripotent stem cell self-renewal and reprogramming
May 5th 2018 – Pavia (Italy) University of Pavia, Collegio Ghislieri, Lectio Magistralis for the Research Day,
Title: Chasing cell identity: from embryos to stem cells
February 23rd 2018 - Vienna (Austria) IMP – IMBA, SY-STEM the next generation of stem cell researchers International meeting
Title: Direct generation of human naïve induced pluripotent stem cells from somatic cells in microfluidics.
November 22nd 2017 – Milan (Italy) TIGET - San Raffaele
Title: Metabolic and transcriptional control of pluripotent stem cells
November 20th 2017 - Cold Spring Harbor Laboratories (NY, USA) STATs: IMPORTANCE IN BASIC & CLINICAL CANCER RESEARCH international meeting
Title: LIF/Stat3 signal reshapes the metabolic profile of Pluripotent Stem cells
October 2016 – Dresden (Germany) CRTD “Rising Star Lectures”
Title: Metabolic and transcriptional regulation of Pluripotency”.
September 24th 2014 – Pisa (Italy) FISV 2014
Title: “Cracking the naive Pluripotency code”
June 8th 2013 – University of Coimbra (Portugal) BEB Symposium
Title: Integration of signalling pathways by the gene regulatory network of pluripotent cells

Publications
Yordanov B, Dunn SJ, Kugler H, Smith A, Martello G, Emmott S. A Method to
Identify and Analyze Biological Programs through Automated Reasoning. NPJ Syst
Biol Appl. 2016 Jul 7;2. pii: 16010. doi: 10.1038/npjsba.2016.10.

Carbognin E, Betto RM, Soriano ME, Smith AG, Martello G. Stat3 promotes
mitochondrial transcription and oxidative respiration during maintenance and
induction of naive pluripotency. EMBO J. 2016 Mar 15;35(6):618-34. doi:
10.15252/embj.201592629.

Montagner M, Martello G, Piccolo S. Monitoring Smad Activity In Vivo Using the
Xenopus Model System. Methods Mol Biol. 2016;1344:245-59. doi:
10.1007/978-1-4939-2966-5_15.

Martello G, Smith A. The nature of embryonic stem cells. Annu Rev Cell Dev
Biol. 2014;30:647-75. doi: 10.1146/annurev-cellbio-100913-013116. Review.

Stuart HT, van Oosten AL, Radzisheuskaya A, Martello G, Miller A, Dietmann S,
Nichols J, Silva JC. NANOG amplifies STAT3 activation and they synergistically
induce the naive pluripotent program. Curr Biol. 2014 Feb 3;24(3):340-6. doi:
10.1016/j.cub.2013.12.040.

Leitch HG, Nichols J, Humphreys P, Mulas C, Martello G, Lee C, Jones K, Surani
MA, Smith A. Rebuilding pluripotency from primordial germ cells. Stem Cell
Reports. 2013 Jun 4;1(1):66-78. doi: 10.1016/j.stemcr.2013.03.004.

Martello G, Bertone P, Smith A. Identification of the missing pluripotency
mediator downstream of leukaemia inhibitory factor. EMBO J. 2013 Oct
2;32(19):2561-74. doi: 10.1038/emboj.2013.177.

Martello G, Sugimoto T, Diamanti E, Joshi A, Hannah R, Ohtsuka S, Göttgens B,
Niwa H, Smith A. Esrrb is a pivotal target of the Gsk3/Tcf3 axis regulating
embryonic stem cell self-renewal. Cell Stem Cell. 2012 Oct 5;11(4):491-504. doi:
10.1016/j.stem.2012.06.008.

Inui M, Montagner M, Ben-Zvi D, Martello G, Soligo S, Manfrin A, Aragona M,
Enzo E, Zacchigna L, Zanconato F, Azzolin L, Dupont S, Cordenonsi M, Piccolo S.
Self-regulation of the head-inducing properties of the Spemann organizer. Proc
Natl Acad Sci U S A. 2012 Sep 18;109(38):15354-9.

Inui M, Manfrin A, Mamidi A, Martello G, Morsut L, Soligo S, Enzo E, Moro S,
Polo S, Dupont S, Cordenonsi M, Piccolo S. USP15 is a deubiquitylating enzyme for
receptor-activated SMADs. Nat Cell Biol. 2011 Sep 25;13(11):1368-75. doi:
10.1038/ncb2346.

Martello G, Rosato A, Ferrari F, Manfrin A, Cordenonsi M, Dupont S, Enzo E,
Guzzardo V, Rondina M, Spruce T, Parenti AR, Daidone MG, Bicciato S, Piccolo S. A
MicroRNA targeting dicer for metastasis control. Cell. 2010 Jun
25;141(7):1195-207. doi: 10.1016/j.cell.2010.05.017.

Inui M, Martello G, Piccolo S. MicroRNA control of signal transduction. Nat
Rev Mol Cell Biol. 2010 Apr;11(4):252-63. doi: 10.1038/nrm2868.

Dupont S, Mamidi A, Cordenonsi M, Montagner M, Zacchigna L, Adorno M,
Martello G, Stinchfield MJ, Soligo S, Morsut L, Inui M, Moro S, Modena N,
Argenton F, Newfeld SJ, Piccolo S. FAM/USP9x, a deubiquitinating enzyme essential
for TGFbeta signaling, controls Smad4 monoubiquitination. Cell. 2009 Jan
9;136(1):123-35. doi: 10.1016/j.cell.2008.10.051.

Martello G, Zacchigna L, Inui M, Montagner M, Adorno M, Mamidi A, Morsut L,
Soligo S, Tran U, Dupont S, Cordenonsi M, Wessely O, Piccolo S. MicroRNA control
of Nodal signalling. Nature. 2007 Sep 13;449(7159):183-8.

Cordenonsi M et al - Integration of TGF-b and Ras/MAPK signaling through p53 phosphorylation. Science. 2007 Feb 9;315(5813)

List of taught course units in A.Y. 2018/19
Degree course code (?) Degree course track Course unit code Course unit name Credits Year Period Lang. Teacher in charge
ME1726 COMMON MEL1000195 8 1st Year Second
semester
ITA MICHELANGELO CORDENONSI
ME1727 COMMON MEL1000195 8 1st Year Second
semester
ITA GRAZIANO MARTELLO
ME1934 001PD MEP7079238 8 1st Year First
semester
ENG CLAUDIA DEL VECCHIO
ME1934 002PD MEP7079238 8 1st Year First
semester
ENG CLAUDIA DEL VECCHIO
ME1934 001PD MEP3052685 6 2nd Year First
semester
ENG GRAZIANO MARTELLO
ME1934 002PD MEP3052685 6 2nd Year First
semester
ENG GRAZIANO MARTELLO