MARZANO CRISTINA

Contacts
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Structure Department of Pharmaceutical and Pharmacological Sciences
Telephone 0498275347
Qualification Professore associato confermato
Scientific sector CHIM/08 - PHARMACEUTICAL CHEMISTRY
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Office hours
Monday from 12:30 to 14:00 Dipartimento di Scienze del Farmaco
Tuesday from 12:30 to 14:00 Dipartimento di Scienze del Farmaco
Wednesday from 12:30 to 14:00 Dipartimento di Scienze del Farmaco
Thursday from 12:30 to 14:00 Dipartimento di Scienze del Farmaco
(updated on 03/05/2018 16:02)

Curriculum Vitae
EDUCATION.
1995: Ph.D. in Pharmaceutical Sciences at the University of Padova, Italy.
1991: Degree in Pharmacy (110/110 cum laude) at the University of Padova, Italy.
PROFESSIONAL EXPERIENCE.
2014-present: Associate Professor of Medicinal Chemistry at the Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Italy.
1997-2014: Assistant Professor of Medicinal Chemistry at the Department of Pharmaceutical Sciences, University of Padova, Italy.

1995-1997: A.I.R.C. (Italian Association for Cancer Therapy) Fellow.
1994: Visiting Researcher at the Curie Institute, Paris (France).
1991-1994: Ph.D. program in Pharmaceutical Sciences, Department of Pharmaceutical Sciences, University of Padova, Italy.
SCIENTIFIC and RESEARCH INTERESTS.
Current research interests are in Bioinorganic and Medicinal Chemistry, Cellular and Molecular Biology. Her work focuses especially on the development of target-specific anticancer metallodrugs. A close eye is thrown to the recognition of the chemical features and molecular mechanisms responsible for the antitumor activity of new Cu(I,II), Pt(II), Pd(II), Ru(II,III) and Au(I,III) complexes by means of suitable subcellular, cellular and animal model systems. The studies, being revolved around the identification of structure-activity relationships (SARs), aim at the design of novel anticancer agents with improved pharmacological properties in comparison with the reference chemotherapeutic drugs.
CM is co-author of more than 130 scientific publications and 4 invited reviews in peer-reviewed international journals, more than 150 communications in National and International Conferences (some of which upon invitation).
She is co-inventor in 4 pharmaceutical patents concerning the use of metal compounds as antitumor agents.

CM cooperates with national and international chemical and pharmaceutical companies and she has established collaborations with different international University. She received funds from public institutions and private companies for the development of several research projects.

Research areas
Development of novel anticancer coordination compounds. Special attention is paid to the recognition of the chemical features and molecular mechanisms responsible for the antitumor activity of new metal complexes, by means of suitable animal, cellular and subcellular model systems. The studies aim at the design of novel anticancer agents with improved pharmacological properties in comparison with the reference chemotherapeutic metallodrugs.

Publications
Gandin, Valentina, Ceresa, Cecilia, Esposito, Giovanni, Indraccolo, Stefano, Porchia, Marina, Tisato, Francesco, Santini, Carlo, Pellei, Maura, Marzano, Cristina (2017). Therapeutic potential of the phosphino Cu(I) complex (HydroCuP) in the treatment of solid tumors. SCIENTIFIC REPORTS, vol. 7, p. 1-12, ISSN: 2045-2322, doi: 10.1038/s41598-017-13698-1

Jopp, Melanie, Becker, Jonathan, Becker, Sabine, Miska, Andreas, GANDIN, VALENTINA, MARZANO, CRISTINA, Schindler, Siegfried (2017). Anticancer activity of a series of copper(II) complexes with tripodal ligands. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 132, p. 274-281, ISSN: 1768-3254, doi: 10.1016/j.ejmech.2017.03.019 -

Porchia, Marina, Tisato, Francesco, Zancato, Mirella, Gandin, Valentina, Marzano, Cristina (2017). In vitro antitumor activity of water-soluble copper(I) complexes with diimine and monodentate phosphine ligands. ARABIAN JOURNAL OF CHEMISTRY, ISSN: 1878-5352, doi: 10.1016/j.arabjc.2017.09.003

Gandin Valentina, Trenti Annalisa., Porchia Marina., Tisato Francesco., Giorgetti Marco., Zanusso Ilenia., Trevisi Lucia., Marzano Cristina. (2015). Homoleptic phosphino copper(i) complexes with in vitro and in vivo dual cytotoxic and anti-angiogenic activity. METALLOMICS, vol. 7, p. 1497-1507, ISSN: 1756-5901, doi: 10.1039/C5MT00163C

C. Santini, M. Pellei, V. Gandin, M. Porchia, F. Tisato, C. Marzano (2014). Advances in Copper Complexes as Anticancer Agents. CHEMICAL REVIEWS, vol. 114, p. 815-862, ISSN: 0009-2665, doi: 10.1021/cr400135x

The complete list of publications:
https://www.research.unipd.it/simple-search?query=cristina+marzano#.Wuwi8bi2qNZ

List of taught course units in A.Y. 2019/20
Degree course code (?) Degree course track Course unit code Course unit name Credits Year Period Lang. Teacher in charge
ME1861 999PD MEN1036276 8 1st Year (2019/20) First
semester
ITA BARBARA SCOLARO
FA1732 COMMON MEP3051728 12 3rd Year (2019/20) First
semester
ITA CRISTINA MARZANO
FA1732 COMMON MEP3051831 6 5th Year (2019/20) First
semester
ITA CRISTINA MARZANO