FABRIS LUCA

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Structure Department of Molecular Medicine
Qualification Professore associato confermato
Scientific sector MED/12 - GASTROENTEROLOGY
University telephone book  Show
 

Office hours
Tuesday from 16:00 to 17:00 Palasanità, room#27 Appuntamento da concordare via e-mail o al telefono (049-821-3131)
(updated on 27/06/2018 18:50)

Proposals for thesis
1) Gender-related differences in biliary repair: analysis of animal models and clinical correlates with human pathologies.
2) Unravelling the mechanisms of lymphatic dissemination in Cholangiocarcinoma: the role of tumor reactive stroma.
3) Phenotyping of Non Alcoholic Steatohepatitis (NASH)-associated Cholangiocarcinoma.

Curriculum Vitae
With a Medical degree in Italy, upon his PhD in 1997 at University of Milan, Italy, after a research program developed at University of Birmingham, UK, Luca Fabris was nominated assistant Professor at the University of Padua, School of Medicine. Currently, as associate Professor in Gastroenterology, he leads a laboratory of experimental Hepatology in the Department of Molecular Medicine, in the same University (Istituto Vallisneri).
Over the last 20 years, he has focused his scientific interests on topics related to pathophysiology of cholangiopathies, both of inflammatory and neoplastic origin, mainly with liver cell biology studies. From 2012, he has an appointment as adjunct Professor in the Yale University (New Haven, CT, USA), where he is involved in the program of genetic biliary diseases and cancers, and he is consultant of a NIH Grant (R01DK101528, PI: Prof Spirli).
On the clinical side, he has developed a longstanding experience, mostly devoted to the clinical management of rare liver diseases, in particular primary cholangiopathies. From 2012 to 2016, Dr Fabris was a steering committee member of the International Primary Sclerosing Cholangitis Study Group. Within the same study group, he is currently co-chairing the working group on "Malignancies in PSC" (with Prof. JM Banales).
From 2016, Dr Fabris is a steering committee member of the AASLD Special Interest Group on Cholestasis and Biliary Diseases.

Lecturer's Curriculum (PDF): 0DB6F8E28658077E44E659F595F92375.pdf


Research areas
The major goal of my research is to study the cell biology of biliary epithelial cells and apply this knowledge to understand the pathophysiology of biliary tree diseases (cholangiopathies). This goal is pursued within two specific areas of interest:
1. Genetic and immune-mediated cholangiopathies, as models of liver disease to study:
a) liver repair mechanisms, with focus on the role of ductular reaction as it relates to the progression of chronic biliary damage
b)epithelial-mesenchymal interactions and cross-talk mechanisms, with focus on the involvement of macrophages and fibrocytes in liver fibrosis

2. Cholangiocarcinoma, with main focus on mechanisms of cancer invasiveness, by unravelling:
a) tumor-stroma interactions and pro-invasive role of tumor reactive stroma
b) characterization of tumor biomarkers of enhanced invasive phenotype as tool for molecularly targeted therapies
c) development of animal models linking chronic inflammation to cancer

My scientific and professional interests extend to: 1) clinical management of rare liver diseases, 2) definition and application of outcome indicators (value-based medicine in hepatology) in immune-related liver diseases (AIH, PBC, PSC).

Publications


Lecturer's Publications (PDF): 0DB6F8E28658077E44E659F595F92375.pdf

List of taught course units in A.Y. 2018/19
Degree course code (?) Degree course track Course unit code Course unit name Credits Year Period Lang. Teacher in charge
IF0362 001LE MVO2045622 11 2nd Year First
semester
ITA LUCA BARGELLONI
ME1844 999TV MEP4063911 6 2nd Year First
semester
ITA CARLO AGOSTINI
ME1868 COMMON MEN1035143 13 1st Year Second
semester
ITA LUCIANA CAENAZZO
ME1726 COMMON MEP5071108     ITA FABIO FARINATI
»   MEP5071109 4 4th Year Second
semester
ITA FABIO FARINATI
»   MEP5071109 4 4th Year Second
semester
ITA EDOARDO VINCENZO SAVARINO
»   MEP5071110 4 4th Year Second
semester
ITA SAVERIO PARISI
»   MEP5071110 4 4th Year Second
semester
ITA SAVERIO PARISI
ME1727 COMMON MEP5071108     ITA ANNAROSA FLOREANI
»   MEP5071109 4 4th Year Second
semester
ITA ANNAROSA FLOREANI
»   MEP5071109 4 4th Year Second
semester
ITA EDOARDO VINCENZO SAVARINO
»   MEP5071110 4 4th Year Second
semester
ITA SAVERIO PARISI
»   MEP5071110 4 4th Year Second
semester
ITA SAVERIO PARISI
ME1728 COMMON MEP5071108     ITA FRANCESCO PAOLO RUSSO
»   MEP5071109 4 4th Year Second
semester
ITA FRANCESCO PAOLO RUSSO
»   MEP5071109 4 4th Year Second
semester
ITA EDOARDO VINCENZO SAVARINO
»   MEP5071110 4 4th Year Second
semester
ITA SAVERIO PARISI
»   MEP5071110 4 4th Year Second
semester
ITA SAVERIO PARISI
ME1729 COMMON MEP5071108     ITA PATRIZIA BURRA
»   MEP5071109 4 4th Year Second
semester
ITA PATRIZIA BURRA
»   MEP5071109 4 4th Year Second
semester
ITA EDOARDO VINCENZO SAVARINO
»   MEP5071110 4 4th Year Second
semester
ITA MONICA BASSO
»   MEP5071110 4 4th Year Second
semester
ITA SAVERIO PARISI
ME1726 COMMON MEP8085240 4 1st Year Second
semester
ITA LUCA FABRIS