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Structure Department of Biology
Telephone 0498276308
Qualification Ricercatore a tempo determinato di tipo A
Scientific sector MED/04 - GENERAL PATHOLOGY
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Office hours
Contattare via mail per appuntamento
(updated on 23/09/2019 16:35)

Proposals for thesis
Our research group is interested in studying the immune evasion mechanisms in tumor context and chronic infections.

In particular, we are focused in investigating:

- the mechanisms that lead to antigen presentation impairment in colorectal cancer, with attention to MHC-II antigen presenting molecule and immunne receptor CD300e;

- the signaling pathway triggered upon CD300e activation;

- the mechanisms that lead to antigen presentation impairment in Helicobacter pylori infection, one of the major risk factor for gastric cancer development.

To this aim, we work mainly with primary immune cells isolated from healthy donosrs and tumor cell lines. We adopt combined approaches of cell biology, biochemistry and molecular biology.

Interested students can contact me for more informations.

Curriculum Vitae
Gaia Codolo
Assistant Professor
ORCID 0000-0002-7793-2549

2003 Bachelor Degree in Molecular Biology, University of Padua
2005 Master Degree in Biomedical Sciences, University of Padua
2010 Ph.D. Degree in Biosciences curriculum Cell Biology and Pathology, University of Padua

2017-to date Assistant Professor in General Pathology at the Department of Biology, University of Padua
2013-2017 Senior post-doc, Assegno di ricerca senior, Department of Biology, University of Padua, Padua, Italy
2013 Postdoctoral fellow at Max Plank Institute for Cell Biology and Genetics, Dresden, Germany
2012 Postdoctoral fellow, Department of Biology, University of Padua, Padua, Italy
2010-2012 Postdoctoral fellow, Department of Biology, University of Padua, Padua, Italy
2007-2010 Ph.D. student in Biosciences curriculum Cellular Biology, Department of Biomedical Sciences, University of Padua, Italy
2005-2006 Research fellow, University of Firenze, Firenze, Italy

2019 PRID seed, Department of Biology, University of Padua
2018 Integrated Research Department Budget (BIRD) from University of Padova
2015 Assegno di ricerca senior, University of Padua
2013 Journal of Cell Science fellowship to join Zerial's laboratory at the MPI-CBG, Dresden, Germany
2012 Giovani Studiosi Grant,(University of Padua
2012-2013 CA.RI.PLO. postdoctoral fellowship
2010-2012 Postdoctoral fellowship, University of Padua

26 peer reviewed papers. 9 as first author and 1 as corresponding author.
Scopus h-index 13; 844 citations.

Research areas
G. CODOLO is interested in elucidating the MOLECULAR PATHWAYS that regulate the innate IMMUNE RESPONSE both in CANCER and in CHRONIC INFECTIONS.
In particular, her research is focused on the study of the immune escape mechanisms in cancer and chronic infection.

1. Capitani N*, Codolo G*, et al. The lipoprotein HP1454 of Helicobacter pylori regulates T-cell response by shaping T-cell receptor signalling. Cell Microbiol. 2019 Jan 15:e13006. *equal contribution
2. Biglari S, et al. Simulating Inflammation in a Wound Microenvironment Using a Dermal Wound-on-a-Chip Model. Adv Healthc Mater. 2019 Jan;8(1):e1801307
3. Gatto M, et al. SERPINB3 Delays Glomerulonephritis and Attenuates the Lupus-Like Disease in Lupus Murine Models by Inducing a More Tolerogenic Immune Phenotype. Front Immunol. 2018 Sep 11;9:2081.
4. Pagliari M, et al. Helicobacter pylori affects the antigen presentation activity of macrophages modulating the expression of the immune receptor CD300E through miR-4270. Front Immunol. 2017 Oct 12;8:1288.
5. Vallese F, et al. Helicobacter pylori antigenic Lpp20 is a structural homologue of Tipα and promotes epithelial-mesenchymal transition. Biochim Biophys Acta. 2017 Dec;1861(12):3263-3271.
6. D’Elios MM, et al. The Helicobacter cinaedi antigen CAIP participates in atherosclerotic inflammation by promoting the differentiation of macrophages in foam cells. Scientific Report. 2017 7:40515.
7. Vila-Caballer M, et al. A pH-sensitive stearoyl-PEG-poly(methacryloyl sulfadimethoxine)-decorated liposome system for protein delivery: An application for bladder cancer treatment. J Control Release. 2016 Sep 28;238:31-42.
8. Pozzobon T, et al. The Treponema pallidum antigen TpF1 influences secondary syphilis by impacting on the angiogenic response of the host. Sci Rep. 2016 6:18785
9. Munari F, et al. Macrophages Triggers the Th17 Response in Human Chronic Gastritis. J. Immunol. 2014 193(11):5584-94
10. Casellato A, et al. The C2 fragment from Neisseria meningitidis antigen NHBA increases endothelial permeability by destabilizing adherens junctions. Cell Microbiol. 2014 16(6):925-37
11. Amedei A*, Codolo G*, et al. Cerebrospinal fluid T-regulatory cells recognize Borrelia burgdorferi NapA in chronic Lyme borreliosis. Int J Immunopathol and Pharmacol. 2013 26(4):907-15 *Equal contribution.
12. Codolo G, et al. Orchestration of inflammation and adaptive immunity in Borrelia burgdorferi-induced arthritis by NapA. Arthritis and Rheumatism 2013 65(5):1232-42.
13. Codolo G, et al. Triggering of inflammasome by aggregated α-synuclein, an inflammatory response in synucleinopathies. PLOS One 2013 8(1):e55375
13. Codolo G, et al. HP-NAP inhibits the growth of bladder cancer in mice by activating a cytotoxic Th1 response. Cancer Immunol Immunother 2012 61(1):31-40
14. Codolo G, et al. Structure and immunological properties of NapA of Borrelia burgdorferi. BBA Proteins and Proteomics 2010 1804(12):2191-7.
15. Calore F, et al. Endosome-mitochondria juxtaposition during apoptosis induced by H. pylori VacA. Cell Death Differ. 2010 17(11):1707-16.
16. D'Elios MM, et al. Helicobacter pylori, asthma and allergy. FEMS Immunol Med Microbiol. 2009 56(1):1-8.
17. Codolo G, et al. NapA of Borrelia burgdorferi drives Th17 inflammation in Lyme Arthritis. Arthr and Rheum 2008 58(11):3609-17.
18. Codolo G, et al. The neutrophil-activating protein of Helicobacter pylori down-modulates Th2 inflammation in ovalbumin-induced allergic asthma. Cell Microbiol. 2008 10(11):2355-63.
19. Amedei A, et al. The neutrophil-activating protein of Helicobacter pylori promotes Th1 immune responses. J Clin Invest. 2006 116(4):1092-101.

List of taught course units in A.Y. 2019/20
Degree course code (?) Degree course track Course unit code Course unit name Credits Year Period Lang. Teacher in charge
SC1166 COMMON SCP3053999 6 3rd Year (2019/20) Second