ORSO GENNY

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Structure Department of Pharmaceutical and Pharmacological Sciences
Telephone Ufficio: 049 8275105 Lab: 049 8275099
Qualification Ricercatore a tempo determinato di tipo A
Scientific sector BIO/14 - PHARMACOLOGY
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Office hours
Department of Pharmaceutical and Pharmacological Sciences, Building C, Largo Meneghetti 2, Padova Any day, upon appointment (please contact via e-mail).
(updated on 14/09/2018 17:00)

Proposals for thesis
1)Hereditary Spastic Paraplegia models: mechanisms, targets and pharmacological screening

2) Schizophrenia model: cellular mechanisms of dysbindin loss of function mutations in endocytic trafficking and autophagy

3) Antipsychotic effects on lipid metabolism

Curriculum Vitae
CURRENT POSITION
2018-present: RTDA, SSD BIO/14 , Department of Pharmaceutical and Pharmacological Sciences
University of Padua, Largo Egidio Meneghetti 2, Building C, 35131 Paua, Italy

EDUCATION
1990-1995 Diploma di maturità scientifica, Liceo scientifico G.B Brocchi, Bassano del Grappa (Vi)
2006: Ph.D. in Molecular and Cellular Pharmacology, University of Padua
2001: Degree in Biological Science, University of Padua

RESEARCH EXPERIENCE
2016-2017 Principal Investigator at the IRCCS E.MEDEA Scientific Institute, Neurobiology, computational biology and Pharmacology area, Conegliano (TV)
2009-2016 Principal Investigator at the IRCCS E.MEDEA Scientific Institute, Neurobiology, computational biology and Pharmacology area, Bosisio Parini (LC)
2006-2008: Postdoctoral Research Fellow 2006, early career award, at the Neuroscience Institute of Trinity College of Dublin, Ireland
2006: Ph.D. in Molecular and Cellular Pharmacology, University of Padua

INSTITUTIONAL RESPONSIBILITIES
2014 – present Member of the Faculty Board , PhD Course in Pharmacological Sciences, DSF, University of Padua
2015 – present Member of the Teaching Committee, PhD Course in Pharmacological Sciences, DSF, University of Padua
2018-present Elected Member of Researcher Board of School of Medicine, University of Padua

TEACHING ACTIVITY 1-General Pharmacology and Toxicology (Degree Course: Biotechnology); ECTS 1, 16 hours bench teaching; 2-Plant Biology and Pharmacognosy (Degree Course: Chemistry and Pharmaceutical Techniques); ECTS 5, 40 hours frontal lectures ; 3- Methods of Molecular Pharmacology (PhD program in Pharmacological Sciences); ECTS 1, 6 hours frontal lectures and 14 hours bench teaching

TUTORIAL ACTIVITY
2013 - present Tutor for experimental thesis , degree in Biotechnology, CTF and Biology
2013 – present Supervisor /co-supervisor for research project of PhD students : B. Napoli (2016 - 2019), M. Corrà (2015-2018), S. Gumeni (2010-2013)

MEMBERSHIP IN SCIENTIFIC SOCIETY
Member of Genetic Society of America ( GSA )

RESEARCH PROJECTS AND FUNDS
2017-2020 Collaborator: “A fruit-fly screening model to accelerate development of species-selective vertebrate toxins” . Smart Ideas grant 2017, Ministry of Business, Inoovation and Employent, New Zeland.
2014-2016 PI: “Malattie del motoneurone: analisi di modelli di Drosophila per lo studio del ruolo del metabolismo lipidico nei processi neurodegenerativi, Ministero della Salute, Ricerca Corrente 2014
2013–2017 Coordinator “The neuronal role of lipids: from molecular function of genes to identification of biomarker in juvenile spastic paraplegia forms”. Young Investigator Grant on Pediatric Research 2013, IRP, Fondazione Cariparo.
2013-2018 –Collaborator of the European project NEUROLIPID "Lipid metabolism in the pathogenesis of hereditary spastic paraplegia: genes, biomarkers, and models for therapy” . European Research Projects on Rare Diseases 2013.
2012-2016 Co-investigator : “Schizophrenia pathogenetic mechanisms associated to dysbindin dysfunctions in fly and mouse models”. Progetto Giovani Ricercatori, Ministero del Lavoro, della Salute e delle Politiche Sociali. GR-2010-2315883
2009-2012 Coordinator: “Development of motor neuron disease models in Drosophila”. Progetto Giovani Ricercatori, Ministero del Lavoro, della Salute e delle Politiche Sociali.
2006-2008 Postdoctoral Research Fellow 2006, early career award. Irish Research Council for Science, Engineering and Technology (IRCSET), Irelan

Research areas
1) Drosophila and cellular models of neurological disorders

Part of our research activity is focused on neurological disorders such as Schizophrenia and Hereditary Spastic Paraplegia (HSP). For many neurological diseases the pathogenic mechanism is unknown or unclear making the development of a therapy difficult. In our lab we use Drosophila as model organism to identify the pathogenic mechanisms and/or pharmacological targets linked to human disorders.

HSP. In the past we developed Drosophila models to study the biological function of genes involved in HSP. Our activity is now focused on metabolic dysfunctions associated to HSP pathology. Pharmacological screening tests are in progress in our lab to identify compounds able to rescue lethality and neurological defects, with a specific focus on lipid metabolism as amenable target.

Schizophrenia. We developed a fruit fly model of the schizophrenia susceptibility gene dysbindin and we are working to clarify its function in endocytic trafficking and autophagy in glia and neurons. A parallel study aims to analyze the antipsychotic effects in wild type and loss of function model of dysbindin as well as to explore the metabolic side effects of antipsychotics.


2) Target and toxicant mechanism of Norbormide

A new project started in the lab in 2018 supported by the grant Smart Ideas grant 2017, Ministry of Business, Innovation and employment of New Zealand. In collaboration with Landcare Research and University of Auckland the project aims to identify the norbormide target and develop Drosophila transgenic models to screen species-selective vertebrate toxins.

Publications
1. Claudio D'Amore*, Genny Orso, Alessia Forgiarini, Giulio Ceolotto, David Rennison, Giovanni Ribaudo, Morgan J. Smith, Brian Hopkins, Margaret A. Brimble and Sergio Bova. Synthesis and biological characterization of a new norbormide derived Bodipy FL-conjugated fluorescent probe fpr cell imaging CELL IMAGING. Front. Pharmacol. | doi: 10.3389/fphar.2018.01055.
2. Antonioli L, Caputi V, Fornai M, Pellegrini C, Gentile D, Giron MC, Orso G, Bernardini N, Segnani C, Ippolito C, Csóka B, Haskó G, Németh ZH, Scarpignato C, Blandizzi C, Colucci R. Interplay between colonic inflammation and tachykininergic pathways in the onset of colonic dysmotility in a mouse model of diet-induced obesity. Int J Obes (Lond). 2018 Aug 6. doi: 10.1038/s41366-018-0166-2. [Epub ahead of print]
3. Scheggia D, Mastrogiacomo R, Mereu M, Sannino S, Straub RE, Armando M, Managò F, Guadagna S, Piras F, Zhang F, Kleinman JE, Hyde TM, Kaalund SS, Pontillo M, Orso G, Caltagirone C, Borrelli E, De Luca MA, Vicari S, Weinberger DR, Spalletta G, Papaleo F. Variations in Dysbindin-1 are associated with cognitive response to antipsychotic drug treatment. Nat Commun. 2018 Jun 11;9(1):2265. doi: 10.1038/s41467-018-04711-w.
4. Caputi V, Marsilio I, Filpa V, Cerantola S, Orso G, Bistoletti M, Paccagnella N, De Martin S, Montopoli M, Dall'Acqua S, Crema F, Di Gangi IM, Galuppini F, Lante I, Bogialli S, Rugge M, Debetto P, Giaroni C, Giron MC. Antibiotic-induced dysbiosis of the microbiota impairs gut neuromuscular function in juvenile mice. Br J Pharmacol. 2017 Oct;174(20):3623-3639. doi: 10.1111/bph.13965. Epub 2017 Aug 30.
5. Mushtaq Z, Choudhury SD, Gangwar SK, Orso G, Kumar V. Human Senataxin Modulates Structural Plasticity of the Neuromuscular Junction in Drosophila through a Neuronally Conserved TGFβ Signalling Pathway.Neurodegener Dis. 2016 May 21;16(5-6):324-336.
6. D'Amore C*, Orso G*, Fusi F, Pagano MA, Miotto G, Forgiarini A, De Martin S, Castellani G, Ribaudo G, Rennison D, Brimble MA, Hopkins B, Ferrarese A, Bova S. An NBD Derivative of the Selective Rat Toxicant Norbormide as a New Probe for Living Cell Imaging. Front Pharmacol. 2016 Sep 23;7:315.
7. Papadopoulos C, Orso G, Mancuso G, Herholz M, Gumeni S, Tadepalle N, Jüngst C, Tzschichholz A, Schauss A, Höning S, Trifunovic A, Daga A, Rugarli EI.Spastin binds to lipid droplets and affects lipid metabolism. PLoS Genet. 2015 Apr 13;11(4):e1005149. doi: 10.1371/journal.pgen.1005149. eCollection 2015 Apr.
8. Catanzaro D, Gaude E, Orso G, Giordano C, Guzzo G, Rasola A, Ragazzi E, Caparrotta L, Frezza C, Montopoli M. Inhibition of glucose-6-phosphate dehydrogenase sensitizes cisplatin-resistant cells to death.Oncotarget. 2015 Aug 17.
9. Orso G*, Pendin D*, Liu S, Tosetto J, Moss TJ, Faust JE, Micaroni M, Egorova A, Martinuzzi A, McNew JA, Daga A. Homotypic fusion of ER membranes requires the dynamin-like GTPase atlastin. Nature. 2009 Aug 20;460(7258):978-83. Erratum in: Nature.2010 Apr 8;464(7290):942.
10. Orso G, Martinuzzi A, Rossetto MG, Sartori E, Feany M, Daga A.Disease-related phenotypes in a Drosophila model of hereditary spastic paraplegia are ameliorated by treatment with vinblastine. J Clin Invest. 2005 Nov;115(11):3026-34.
11. Trotta N*, Orso G*, Rossetto MG, Daga A, Broadie K.The hereditary spastic paraplegia gene, spastin, regulates microtubule stability to modulate synaptic structure and function.Curr Biol. 2004 Jul 13;14(13):1135-47.

List of taught course units in A.Y. 2019/20
Degree course code (?) Degree course track Course unit code Course unit name Credits Year Period Lang. Teacher in charge
ME1846 999PD MEO2043919 6 2nd Year (2019/20) First
semester
ITA GENNY ORSO
FA1733 COMMON MEP3052473 9 3rd Year (2019/20) Second
semester
ITA GENNY ORSO