First cycle
degree courses
Second cycle
degree courses
Single cycle
degree courses
School of Medicine
Course unit
MEN1036440, A.A. 2019/20

Information concerning the students who enrolled in A.Y. 2019/20

Information on the course unit
Degree course First cycle degree in
ME1857, Degree course structure A.Y. 2012/13, A.Y. 2019/20
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Number of ECTS credits allocated 10.0
Type of assessment Mark
Course unit English denomination SCIENCE OF LABORATORY MEDICINE
Department of reference Department of Medicine
Mandatory attendance
Language of instruction Italian
Single Course unit The Course unit CANNOT be attended under the option Single Course unit attendance
Optional Course unit The Course unit is available ONLY for students enrolled in BIOMEDICAL LABORATORY TECHNIQUES

Teacher in charge LUISA BARZON MED/46

ECTS: details
Type Scientific-Disciplinary Sector Credits allocated
Basic courses BIO/14 Pharmacology 3.0
Core courses BIO/12 Clinical Biochemistry and Biology 2.0
Core courses MED/46 Laboratory Medicine Techniques 5.0

Course unit organization
Period Second semester
Year 1st Year
Teaching method frontal

Type of hours Credits Teaching
Hours of
Individual study
Lecture 10.0 100 150.0 No turn

Start of activities 10/02/2020
End of activities 30/06/2020
Show course schedule 2019/20 Reg.2012 course timetable

Examination board
Examination board not defined

Prerequisites: Basic knowledge in biology, chemistry, and biochemistry
Target skills and knowledge: After completing the course the student will demonstrate knowledge and understanding of:
Clinical biochemistry and clinical molecular biology.
Techniques of Pharmacology and Toxicology: fundamental concepts of pharmacodynamics and pharmacokinetics and main applications of pharmacology and experimental toxicology, with special reference to the techniques used in TDM and preclinical and clinical trials of drugs.
Medicine techniques laboratory and automation, with particular reference to the innovative techniques of molecular diagnostics.
Examination methods: The exam consists of tests with open and multiple choice questions or an oral exam.
Assessment criteria: Level of knowledge on the topics of the course.
Course unit contents: Clinical biochemistry and clinical molecular biology:
The various stages of a laboratory analysis: pre-analytical, intra-analytical and post-analytical: guidelines, methods of control, quality control, analysis of results; evaluation of the accuracy, precision analytical, internal controls and external quality, total analytical error; reference intervals, threshold, sensitivity and diagnostic specificity, positive and negative predictive value, critical difference. Diagnostic applications: serum proteins, enzymes, tumor markers.

Medicine techniques and laboratory automation:
Principles and techniques of molecular diagnostics; techniques of nucleic acid amplification, nucleic acid hybridization techniques, nucleic acids sequencing techniques, diagnostic applications of molecular techniques. Recombinant DNA technologies and molecolar biotecnologies; Cell biology tecniques. Immunological diagnostic techniques. Spectrophotometric techniques. Organization of the clinical laboratory; Instrumentation, automation, robotics.

Techniques of pharmacology and toxicology:
Pharmacology: pharmacokinetics, pharmacodynamics
Relations between pharmacokinetics and pharmacodynamics
Routes of administration of drugs
Bioavailability and absorption
Steady state, peak, and downstream concentrations
Interval (range) and therapeutic index
Definitions of TDM
TDM: major directions
Clinical trials of the drugs, clinical trials
Drug adverse events; AIFA data bank.
Planned learning activities and teaching methods: Lectures and laboratory exercises.
Additional notes about suggested reading: The teacher will provide the slides of the lectures. For further information bibliography and web bibliography reference will be provided.
Textbooks (and optional supplementary readings)
  • Anna Valerio, QUADERNI DI BIOCHIMICA CLINICA. via Belzoni 118/3, Padova: CLEUP, --. Cerca nel catalogo
  • Maria Rosa Baiocchi, DISPENSE. via Belzoni 118/3, Padova: CLEUP, --.

Innovative teaching methods: Teaching and learning strategies
  • Lecturing
  • Laboratory
  • Problem based learning
  • Case study
  • Interactive lecturing
  • Working in group
  • Questioning
  • Action learning
  • Story telling
  • Problem solving
  • Active quizzes for Concept Verification Tests and class discussions
  • Video shooting made by the teacher/the students
  • Use of online videos
  • Loading of files and pages (web pages, Moodle, ...)

Innovative teaching methods: Software or applications used
  • Moodle (files, quizzes, workshops, ...)
  • Top Hat (active quiz, quiz)

Sustainable Development Goals (SDGs)
Good Health and Well-Being Quality Education Gender Equality