First cycle
degree courses
Second cycle
degree courses
Single cycle
degree courses
School of Medicine
Course unit
MEN1033912, A.A. 2019/20

Information concerning the students who enrolled in A.Y. 2019/20

Information on the course unit
Degree course First cycle degree in
ME1854, Degree course structure A.Y. 2011/12, A.Y. 2019/20
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Number of ECTS credits allocated 8.0
Type of assessment Mark
Course unit English denomination PROPAEDEUTIC SCIENCES
Department of reference Department of Neurosciences
Mandatory attendance
Language of instruction Italian
Single Course unit The Course unit CANNOT be attended under the option Single Course unit attendance
Optional Course unit The Course unit is available ONLY for students enrolled in DENTAL HYGIENE

Teacher in charge ALESSANDRO NEGRO BIO/10
Other lecturers FRANCESCO CIDENI

ECTS: details
Type Scientific-Disciplinary Sector Credits allocated
Educational activities in elective or integrative disciplines CHIM/03 General and Inorganic Chemistry 2.0
Basic courses BIO/10 Biochemistry 4.0
Basic courses FIS/07 Applied Physics (Cultural Heritage, Environment, Biology and Medicine) 2.0

Course unit organization
Period First semester
Year 1st Year
Teaching method frontal

Type of hours Credits Teaching
Hours of
Individual study
Lecture 8.0 80 120.0 No turn

Start of activities 30/09/2019
End of activities 18/01/2020
Show course schedule 2019/20 Reg.2011 course timetable

Examination board
Board From To Members of the board
7 SCIENZE PROPEDEUTICHE 01/10/2019 30/09/2020 NEGRO ALESSANDRO (Presidente)
CIDENI FRANCESCO (Membro Effettivo)

Prerequisites: There are no specific preparatory requirements.
Target skills and knowledge: The student acquires basic chemistry concepts through the integrated development of theoretical lessons. The student acquires knowledge about the structure and function of biological macromolecules, metabolism and metabolism regulation strategies
Examination methods: The profit verification will take place in a written way through tests with open questions and exercises. There are no on-going assessments but only one final verification.
Assessment criteria: Evaluation criteria: The students' level of knowledge will be assessed by analyzing both the acquisition of specific concepts belonging to the discipline and the ability to use the acquired knowledge. The knowledge of biochemistry will be evaluated by analyzing both the acquisition of specific concepts belonging to the discipline, and the ability to use the knowledge acquired in an integrated manner.
Course unit contents: Carbohydrates: Monosaccarides, Disaccarides Sucrose e Lactose, Polysaccarides, Starch and Cellulose, Jaluronic acid, Heparin. Lipid: Fatty Acid, Triglicerides, Phosphoglicerides, colesterol, Biological Membrane. Amino acid e Protein Structure Amino acid classification. Primary, Secondary tertiary and Quaternary structure of proteins. Structure and function relationships in proteins and enzymes. Enzymes: mechanisms of catalysis, Michaelis-Menten kinetic, kinetic parameters, activators and inhibitors. Mechanisms of regulations. allosteric enzymes. Mioglobin, hemoglobin. Heme-globin bond, ossigenation, cooperativity, allosteric effectors and the Bohr effect.Bioenergetics.Carbohydrates and lipids metabolism: Transformation of energy during the metabolism. Esergonic and endergonic reactions, coupled reactions. Anabolism and catabolism. High energy compounds relevant to biochemistry. ATP. Substrate-level phosphorylation. The biological oxidation reactions. Structure and function of the respiratory chain. Oxidative phosphorylation in mitochondria and chemiosmotic mechanism of coupling. Physiologically relevant carbohydrates. Glucose metabolism and its regulation: glycolysis, pentose phosphate pathway, Krebs cycle. Gluconeogenesis. Glycogen metabolism. Physiologically relevant lipids. Lipid metabolism and its regulation: fatty acid biosynthesis, elongation, desaturation; Plasma lipoproteins: classification, structure, function, analysis. Digestion of lipids and chilomicrons formation. Metabolism of lipoproteins. Adipose tissue biochemistry, lipogenesis and lipolysis. fatty acids activation and oxidation. Mechanisms of fatty acid oxidation ketogenesis and ketone bodies utilization. Propionic acid utilization. Relationships between lipid and carbohydrate metabolism: role of the metabolic hormones and the tissues. Metabolism of proteins aminoacids Protein turnover. Alpha aminic nitrogen fate: deamination, transamination, glutamine synthesis, urea cycle. Catabolism of the carbon backbone of aminoacids. Hormones classification and general mechanisms of action. Cell surface and intracellular receptors. Intracellular messengers: cAMP and adenylate cyclase system, protein kinases and phosphatases, cGMP, phosphatidylinositols and Ca2+. Nitric oxide: synthesis and action mechanisms. Receptors with tyrosine kinase activity, insulin receptor. Steroid hormones receptors and action mechanisms.
Planned learning activities and teaching methods: Direct teaching activity, through the use of computer tools, the basic concepts of biochemistry. You will follow a step by step approach that provides an illustration of topics gradually more complicated formulas of the compounds to the structure of macromolecules to the relations of metabolism and its regulation pathways.
Additional notes about suggested reading: The presence of students during direct teaching activities are strictly recommended in order to acquire the material presented during lectures. At the end of each lectures the teaching will allow the students to access to slide material in pdf format.
Textbooks (and optional supplementary readings)
  • Jeremy M. Berg, John L. Tymoczko, Lubert Stryer, Biochimica. --: Zanichelli, 2012. Cerca nel catalogo
  • David L. Nelson, Michael M. Cox, I principi di biochimica di Lehninger. --: Zanichelli, 2018. Cerca nel catalogo
  • Fondamenti di biochimica, Donald Voet, Judith G. Voet, Charlotte W. Pratt. --: Zanichelli, 2017. Cerca nel catalogo

Innovative teaching methods: Teaching and learning strategies
  • Lecturing
  • Problem based learning
  • Case study
  • Problem solving

Sustainable Development Goals (SDGs)
Good Health and Well-Being Life on Land