First cycle
degree courses
Second cycle
degree courses
Single cycle
degree courses
School of Medicine
Course unit
MEP4063586, A.A. 2019/20

Information concerning the students who enrolled in A.Y. 2019/20

Information on the course unit
Degree course First cycle degree in
ME1844, Degree course structure A.Y. 2014/15, A.Y. 2019/20
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Degree course track GENERICO - SEDE DI TREVISO [999TV]
Number of ECTS credits allocated 6.0
Type of assessment Mark
Course unit English denomination GENERAL PATHOLOGY AND MICROBIOLOGY
Department of reference Department of Medicine
Mandatory attendance
Language of instruction Italian
Single Course unit The Course unit CANNOT be attended under the option Single Course unit attendance
Optional Course unit The Course unit is available ONLY for students enrolled in NURSING

Teacher in charge MARINA BORTOLAMI MED/05

ECTS: details
Type Scientific-Disciplinary Sector Credits allocated
Basic courses MED/04 General Pathology 4.0
Basic courses MED/07 Microbiology and Clinical Microbiology 2.0

Course unit organization
Period Second semester
Year 1st Year
Teaching method frontal

Type of hours Credits Teaching
Hours of
Individual study
Lecture 6.0 60 90.0 No turn

Start of activities 10/02/2020
End of activities 30/06/2020
Show course schedule 2019/20 Reg.2014 course timetable

Prerequisites: Basic knowledge on Biology, Biochemistry, Anatomy and Physiology
Target skills and knowledge: The purpose of this course is to ensure that the student, through the scientific skills obtained, can understand the pathophysiological mechanisms underlying human diseases. At the end of the course the students will be able to establish the correct relations between cause and effect, identifying the sites of action of cellular and tissue pathological agents.
Examination methods: Written test including open questions and multiple choice questions
Assessment criteria: The evaluation is based on the assessment of the knowledge acquired by the students and on the ability to present, in a complete and comprehensible way, the main aspects of the subject studied with particular reference to the ability to link between different topics. The precise evaluation criteria will be defined by the teacher at the beginning of the lessons.
Course unit contents: General Pathology
1.Etiology and pathogenesis concepts.
2. Physical, chemical and biological agents: examples and mechanism of damage. Oxidative damage: free radicals; antioxidant mechanisms.
3. Cellular and molecular pathology. Degenerative processes. Intracellular accumulation disorders. Extracellular storage disorders. Protein aggregate disorders. Damage and cell death. Concepts and definitions of atrophy, hypertrophy, hyperplasia, metaplasia, dystrophy, dysplasia.
4. Inflammation. Acute inflammation. Vascular phase. Chemical mediators of acute inflammation. Inflammatory cells. Cellular phase. Chemotaxis. Chemokines. Phagocytosis. Chronic inflammation. Types of exudate. Abscess, granulomas. Reparative processes. Granulation tissue. Wound healing. Systemic reactions.
5. Immunity. Cells of the innate and acquired immune response. MHC and antigen presentation. The complement system. Cytokines and chemokines.
Immunopathology. Hypersensitivity classification and tissue damage mechanisms. Autoimmune diseases. Primary and acquired immunodeficiencies.
6. Blood disorders: disorders of blood and blood cells. Anemias. Hemoglobinopathies. White blood cells and leukocytosis. Platelets and the process of hemostasis and coagulation. Bleeding. Thrombotic and embolic processes. Shock: etiology and mechanisms of compensation. Atheromatous process. Risk factor for atherosclerosis.
7. Oncology. Classification of the tumors. Benignant and Malignant tumors. Histological classification and morphological features of human tumors. Molecular basis of the transformed cells. Pathogenetic mechanisms. Oncogenes and tumor suppressors genes. Molecular and cellular process of tumor invasiveness. Angiogenesis in cancer. Molecular mechanism of the metastases. Epidemiology of tumors.

1.General microbiology
Structure of procariotic cells. Bacterial accessory structures (capsule, pili, flagella). Bacterial spore. Bacterial metabolim.
Bacterial staining and microscopic observation. Bacterial culture.
General properties of viruses: classification, structure, replication and modality of diffusion.
General properties of fungi and protozoa.
Body districts colonized by microbes and sterile districts. Normal microbial flora and effects on host physiology. Disbiosys.
Mechanisms of microbial pathogenicity.
Antimicrobial drugs. Antibiogramma. Antibiotic resistance: significance, mechanisms and modality of diffusion.
2. Clinical microbiology
Modality of diffusion of mostm relevant pathogens.
General aspects of microbiological diagnosis. Techniques of sample collection, storage and transport to the laboratory.
General aspects and pathogenetic mechanisms of most relevant human pathogens causing sepsis, respiratory tract infections, urinary trat infections, gastrointestinal infections, central nervous system infections. Nosocomial infections. Infections by opportunistic pathogens.
Textbooks (and optional supplementary readings)