First cycle
degree courses
Second cycle
degree courses
Single cycle
degree courses
School of Science
Course unit
SCN1037601, A.A. 2019/20

Information concerning the students who enrolled in A.Y. 2019/20

Information on the course unit
Degree course Second cycle degree in
SC1731, Degree course structure A.Y. 2014/15, A.Y. 2019/20
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Number of ECTS credits allocated 6.0
Type of assessment Mark
Course unit English denomination MOLECULAR AND CELLULAR BIOLOGY
Website of the academic structure
Department of reference Department of Biology
E-Learning website
Mandatory attendance
Language of instruction Italian
Single Course unit The Course unit can be attended under the option Single Course unit attendance
Optional Course unit The Course unit can be chosen as Optional Course unit

Other lecturers CHIARA RAMPAZZO BIO/06

ECTS: details
Type Scientific-Disciplinary Sector Credits allocated
Core courses BIO/06 Comparative Anatomy and Citology 3.0
Core courses BIO/11 Molecular Biology 2.0
Core courses MED/04 General Pathology 1.0

Course unit organization
Period First semester
Year 1st Year
Teaching method frontal

Type of hours Credits Teaching
Hours of
Individual study
Lecture 6.0 48 102.0 No turn

Start of activities 30/09/2019
End of activities 18/01/2020
Show course schedule 2019/20 Reg.2014 course timetable

Examination board
Board From To Members of the board
8 BIOLOGIA MOLECOLARE E CELLULARE 2019-2020 01/10/2019 27/11/2020 BERGANTINO ELISABETTA (Presidente)
RAMPAZZO CHIARA (Membro Effettivo)
7 BIOLOGIA MOLECOLARE E CELLULARE 2018-2019 01/10/2018 30/11/2019 BERGANTINO ELISABETTA (Presidente)
RAMPAZZO CHIARA (Membro Effettivo)

Prerequisites: Basic knowledge of molecular and cellular biology acquired during the Bachelor's degree.
Target skills and knowledge: The course provides the cultural elements necessary to understand the relationships between organization and function of the molecules - nucleic acids and proteins - present in the cell nucleus. It provides also the means for a molecular approach to understand the cellular response to extracellular signals.
Examination methods: Written exam with open questions.
Assessment criteria: The knowledge and the comprehension, with analytical and synthetic ability, of the complex regulatory levels of a eukaryotic cell will be verified. Verification of the acquisition of an appropriate and specific lexicon on the topics of the course.
Course unit contents: • Chromatin biology and nuclear organization: chromosomal territories and TAD (Topologically Associated Domain). Nuclear bodies (assembly and functions). Histone variants and histone chaperons. Constitutive chromatin and HP1 proteins. Centromere and telomere chromatin and their non-coding RNAs. Polycomb complexes and facultative chromatin. X chromosome inactivation. Stem cell plasticity and epigenetics. Bivalent Chromatin nuclear reprogramming and IPSC (induced pluripotent stem cells). Nuclear lamina and nucleoli.
• Definition of eukaryotic genes and genomes in the light of systematic sequencing projects; comparison between the genomes of Saccharomyces cerevisiae and Homo sapiens. Results of the ENCODE project and discussion of the meaning of ‘junk DNA’.
• Molecular mechanisms of gene regulation in eukaryotes (to be reviewed) with particular regard to the role of the mediator and activators of transcription. Transcription factors; regulation of transcription at the level of the formation of the open complex in response to an external stimulus or to phases of the development and to epigenetic controls.
• RNA polymerase II, structure and functions; regulation of transcription during elongation and synchronization with normal and alternative splicing. Pervasive transcription. Termination of transcription.
• The eukaryotic genome as an RNA machine: RNA editing; post-transcriptional regulation and role of microRNAs; small RNAs and RNA interference mechanism; some examples of long non-coding RNAs.
Planned learning activities and teaching methods: Classroom lectures.
Additional notes about suggested reading: Scientific papers and reviews on the main topics of the course and reference textbooks for the recovery of prior knowledge. Indications on these materials will be clearly provided as an attachment to the presentations, available to the students on the Moodle page of the course (articles and reviews for each topic covered in class, in pdf format).
Textbooks (and optional supplementary readings)
  • Amaldi, Benedetti, Pesole, Plevani, Biologia molecolare (3a ed.). --: CEA - Distribuzione Zanichelli, 2018. Cerca nel catalogo
  • Lewin, Krebs, Goldstein, Kilpatrick, Lewin's genes XII. --: Jones & Bartlett Learning, 2018. Cerca nel catalogo
  • Lodish, Berk, Kaiser, Krieger, Bretscher, Ploegh, Amon, Scott, Molecular Cell Biology, 7th edition. --: W.H.Freeman & Co Ltd Eds., 2012. Cerca nel catalogo

Innovative teaching methods: Teaching and learning strategies
  • Lecturing
  • Working in group
  • Questioning
  • Peer feedback
  • Peer assessment
  • Active quizzes for Concept Verification Tests and class discussions

Innovative teaching methods: Software or applications used
  • Moodle (files, quizzes, workshops, ...)