First cycle
degree courses
Second cycle
degree courses
Single cycle
degree courses
School of Medicine
MEDICINE AND SURGERY
Course unit
BIOLOGICAL MOLECULES 2
MEP8085602, A.A. 2019/20

Information concerning the students who enrolled in A.Y. 2019/20

Information on the course unit
Degree course 6 years single cycle degree in
MEDICINE AND SURGERY
ME2491, Degree course structure A.Y. 2019/20, A.Y. 2019/20
N0
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Number of ECTS credits allocated 8.0
Type of assessment Mark
Course unit English denomination BIOLOGICAL MOLECULES 2
Department of reference Department of Medicine
Mandatory attendance
Language of instruction English
Branch PADOVA
Single Course unit The Course unit CANNOT be attended under the option Single Course unit attendance
Optional Course unit The Course unit is available ONLY for students enrolled in MEDICINE AND SURGERY

Lecturers
Teacher in charge FULVIO URSINI BIO/10
Other lecturers GIORGIO COZZA BIO/10
MATILDE MAIORINO BIO/10
STEFANO TOPPO BIO/10

ECTS: details
Type Scientific-Disciplinary Sector Credits allocated
Basic courses BIO/10 Biochemistry 8.0

Course unit organization
Period Second semester
Year 1st Year
Teaching method frontal

Type of hours Credits Teaching
hours
Hours of
Individual study
Shifts
Lecture 8.0 80 120.0 No turn

Calendar
Start of activities 02/03/2020
End of activities 12/06/2020
Show course schedule 2019/20 Reg.2019 course timetable

Examination board
Examination board not defined

Syllabus
Prerequisites: To profitably follow the Biochemistry for Medicine II course knowledge of physics, chemistry and structural biochemistry is required. Having acquired the credits by passing the exams of Physics for Medicine and Biochemistry for Medicine I is therefore mandatory for being admitted to the Biochemistry for Medicine II exam. Basic knowledge on cell biology, molecular biology and anatomy is also desirable.

Note: At the time of the learning test, the student is asked to produce a written self-certification stating that the preparatory exams have been passed with positive results
Target skills and knowledge: The student will acquire knowledge on:
1. Structure and function of enzymes
2. Thermodynamic and kinetic bases of metabolism
3. Nutrients and their transformations during the catabolic and anabolic phases of metabolism and energy exchanges associated with these transformations
4. Metabolism of the nitrogen bases and porphyrins
5. Transcriptional, translational and post transcriptional mechanisms of metabolic regulation
It is expected that the student will be able to discuss:
1. The chemical and molecular aspects of the compounds and the metabolic intermediates produced during the catabolic and anabolic phases of metabolism.
2. The mechanisms and significance of the regulation and coordination of metabolism during distinct nutritional conditions and in diabetes, as a paradigmatic metabolic disease.
Examination methods: Where possible, the learning test will take place at a computer terminal and will be integrated, for the graphical and structural aspects, with a hand-written part. Otherwise the learning test will be entirely hand-written.
The acquisition of the required knowledge and skills will be verified by a multiple choices test integrated with some themes or questions to be answered synthetically in a written form, which encompass graphs and molecular structures. Both, multiple choices and themes will deal with arguments presented and discussed during the classroom lessons.
The vote will result from the sum of the scores obtained in the multiple choices (max. 20) and the themes (max. 10). Based on the number of the assessment criteria which the student will be able to satisfy (see below), additional scores might implement the score that the student reached up.
Assessment criteria: Student's performance in the learning test will be assessed by the following criteria:
1. Evidence of understanding of the topics covered during the lessons
2. Ability to discuss, in a critical and integrated way, the metabolic pathways, the relationships between them, the nature of the regulation / metabolic coordination mechanisms and their significance
3. Knowledge of the chemical structure of the major compounds and intermediates produced during metabolism
4. Proper terminology
5. Completeness of the answers
Course unit contents: Enzymology, bioenergetics and conservation of metabolic energy, oxygen, oxidoreductases, carbohydrate metabolism, acetyl-CoA and Krebs cycle, lipid metabolism, plasma lipoprotein metabolism, metabolism of amino acids and of the other compounds containing Nitrogen, signal transduction and regulation mechanisms in distinct nutritional conditions and in diabetes. Metabolic hormones and transcriptional regulation of the metabolism. Role of sirtuins and AMPK in the metabolism.
Planned learning activities and teaching methods: The students will be driven toward a path in which the above-mentioned contents will be discussed during classroom lectures. The use of informatic supports is foreseen (power point slides). These, after being presented and discussed during the classroom lectures, will be made accessible to the students.
The students will be trained with respect to the ability to integrate educational information with informatic support and reference texts.
For specific topics, recent scientific acquisitions will be commented and interpreted at the level of original studies. One of the course principal objective is in fact to give the students tools to understand at molecular level the most up-to date biomedical knowledge.
Additional notes about suggested reading: At the end of each lesson, students will have access to the teaching material by the moodle platform. This material is intended to serve as a trace for the study in-depth over reference texts, which is indeed indispensable.
Textbooks (and optional supplementary readings)
  • Devlin, biochemistry with clinical aspects. --: --, --. Cerca nel catalogo
  • Garrett & Grisham, Biochemistry. --: --, --. Cerca nel catalogo
  • Nelson-Cox, Lehninger principles of Biochemistry. --: --, --. Cerca nel catalogo
  • Siliprandi – Tettamanti, Medical Biochemistry. --: --, --.
  • Voett-Pratt, Biochemistry. --: --, --. Cerca nel catalogo

Innovative teaching methods: Teaching and learning strategies
  • Lecturing
  • Active quizzes for Concept Verification Tests and class discussions

Innovative teaching methods: Software or applications used
  • Moodle (files, quizzes, workshops, ...)

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