First cycle
degree courses
Second cycle
degree courses
Single cycle
degree courses
School of Medicine
MEDICINE AND SURGERY
Course unit
GENE THERAPY
MEP4069737, A.A. 2019/20

Information concerning the students who enrolled in A.Y. 2019/20

Information on the course unit
Degree course 6 years single cycle degree in
MEDICINE AND SURGERY (Ord. 2015)
ME1726, Degree course structure A.Y. 2015/16, A.Y. 2019/20
N0
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Number of ECTS credits allocated 4.0
Type of assessment Mark
Course unit English denomination GENE THERAPY
Department of reference Department of Medicine
Mandatory attendance No
Language of instruction Italian
Branch PADOVA
Single Course unit The Course unit CANNOT be attended under the option Single Course unit attendance
Optional Course unit The Course unit is available ONLY for students enrolled in MEDICINE AND SURGERY (Ord. 2015)

Lecturers
Teacher in charge MARTA TREVISAN MED/07

ECTS: details
Type Scientific-Disciplinary Sector Credits allocated
Educational activities in elective or integrative disciplines MED/07 Microbiology and Clinical Microbiology 4.0

Course unit organization
Period Second semester
Year 1st Year
Teaching method frontal

Type of hours Credits Teaching
hours
Hours of
Individual study
Shifts
Lecture 4.0 32 68.0 No turn

Calendar
Start of activities 02/03/2020
End of activities 12/06/2020
Show course schedule 2019/20 Reg.2015 course timetable

Examination board
Examination board not defined

Syllabus
Prerequisites: Attendance of the microbiology course
Target skills and knowledge: Basic notions of gene therapy approaches; knowledge of the main viral vectors used in gene therapy; current applied technologies; perspective of gene therapy approaches design.
Examination methods: Oral
Assessment criteria: Knowledge of the subject treated and ability to argue and justify the use of various systems for gene therapy; scientific language and terminology skills.
Course unit contents: -Introduction to gene therapy: choice of therapeutic gene and method of administration of the therapeutic gene.
- Nucleic acids with therapeutic function: genes encoding proteins and non-coding nucleic acids.
- Methods of gene transfer: physical methods and chemical methods; viral vectors for gene transfer: gammaretrovirus-based vectors, lentivirus-based vectors, vectors based on adeno-associated virus, adenovirus-based vectors, vectors based on the herpes simplex virus.
- Examples of clinical trials using viral vectors.
- Tumor gene therapy: active, passive and adoptive immunotherapy; gene therapy with suicide genes; use of oncolytic viruses.
- "Gene editing" techniques for gene therapy: introduction to "gene editing", potentiality and use in clinical trials, use of artificial nucleases, Zinc Finger nuclease, Transcription activator-like effector nucleases and CRISPR / Cas9 system.
Planned learning activities and teaching methods: Lectures and studies of recent scientific publications in the field of gene therapy.
Additional notes about suggested reading: The study material will be provided in pdf format by the teacher.
Textbooks (and optional supplementary readings)
  • Mauro Giacca, Terapia genica. --: Springer Verlag, 2011.

Innovative teaching methods: Teaching and learning strategies
  • Case study
  • Interactive lecturing
  • Working in group
  • Learning journal

Innovative teaching methods: Software or applications used
  • Moodle (files, quizzes, workshops, ...)
  • Top Hat (active quiz, quiz)

Sustainable Development Goals (SDGs)
Good Health and Well-Being