First cycle
degree courses
Second cycle
degree courses
Single cycle
degree courses
School of Science
MOLECULAR BIOLOGY
Course unit
CELL BIOLOGY
SCP8085218, A.A. 2018/19

Information concerning the students who enrolled in A.Y. 2018/19

Information on the course unit
Degree course Second cycle degree in
MOLECULAR BIOLOGY
SC2445, Degree course structure A.Y. 2018/19, A.Y. 2018/19
N0
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Degree course track Common track
Number of ECTS credits allocated 9.0
Type of assessment Mark
Course unit English denomination CELL BIOLOGY
Website of the academic structure http://biologiamolecolare.scienze.unipd.it/2018/laurea_magistrale_biologiamolecolare
Department of reference Department of Biology
E-Learning website https://elearning.unipd.it/biologia/course/view.php?idnumber=2018-SC2445-000ZZ-2018-SCP8085218-N0
Mandatory attendance
Language of instruction English
Branch PADOVA
Single Course unit The Course unit can be attended under the option Single Course unit attendance
Optional Course unit The Course unit can be chosen as Optional Course unit

Lecturers
Teacher in charge CHIARA RAMPAZZO BIO/06
Other lecturers FRANCESCO ARGENTON BIO/06

ECTS: details
Type Scientific-Disciplinary Sector Credits allocated
Core courses BIO/06 Comparative Anatomy and Citology 9.0

Course unit organization
Period First semester
Year 1st Year
Teaching method frontal

Type of hours Credits Teaching
hours
Hours of
Individual study
Shifts
Lecture 9.0 72 153.0 No turn

Calendar
Start of activities 01/10/2018
End of activities 18/01/2019

Examination board
Board From To Members of the board
1 CELL BIOLOGY 2018-2019 01/10/2018 30/11/2019 RAMPAZZO CHIARA (Presidente)
ARGENTON FRANCESCO (Membro Effettivo)
MOGNATO MADDALENA (Supplente)

Syllabus
Prerequisites: Basic level of Cell Biology, Molecular Biology and Genetics
Target skills and knowledge: The aim of the course is to provide students with advanced knowledge on Cell Biology and in particular to: (i) explore complex eukaryotic cell processes and their control mechanisms, (ii) understand how gene expression affects cell biology, (iii) learn how cell regulation mechanisms are connected to human diseases.
In particular topics include: 1- fundamental aspects of microscopy and other methodologies used by advanced cell biology 2- nuclear organization and functions, 3- Signal transduction networks in cell proliferation, autophagy, cell differentiation and cancer, 4- cell polarity and stem cells
Examination methods: The knowledge acquired by the student will be evaluated with a written exam organized in two parts.
First part (1 CFU) described in the course contents at section 1 will be assesed with one open question that include a long answer.
the second part (7 CFU) described in the course content at section 2 to 5 will be assessed with six questions that include short or longer answer.
The final grade is expressed as a weighted average between the two parties.
Assessment criteria: The purpose of the examination is to assess the student knowledge on all the topics illustrated in the program of the lecture course. The criteria to evaluate student’s knowledge are:
1) understanding of the topics covered in the course
2) critical ability to connect the acquired knowledge
3) completeness of the acquired knowledge
4) synthesis capacity
5) properties of the terminology used
Students will be evaluated based on the quality of the written exam and also on the participation in class discussions and during journal club presentations.
Course unit contents: The 9 CFU course is organized in about 7 CFU of frontal lectures and 2 CFU dedicated to the presentation and discussion of recent articles on the topics covered in class. The discussion of the articles is an integral part of the program.
Lectures will cover 5 main topics:
1) In vitro cultures, methods for cellular molecular biology. Physical principles behind the most common microscopy techniques.
2) Chromatin Biology and nuclear organization to address fundamental questions in Epigenetics and Gene Regulation as well as in cellular differentiation and nuclear reprograming. Mechanisms of epigenetic regulation, including DNA methylation and post-translational modification of histones, and the roles of chromatin-assembly modifying complexes, non-coding RNAs and nuclear organization. X chromosome inactivation. Cell Memory and Genomic Imprinting. Centromeres and telomeres chromatin.
3) Main principles of autophagy and related diseases
4) Stem cell origins, plasticity and epigenetics. Bivalent Chromatin. Stem cell niche. Adult, Embryonic, and induced pluripotent Stem cells.
5) Signal transduction and cancer. Immortalization, role of telomeres. Malignant transformation, disturbances in signal transduction pathways resulting in malignant transformation, role of failure in signaling pathways regulating cellular proliferation, apoptosis and DNA-repair pathways. Cancer stem cells.
Planned learning activities and teaching methods: The course is organized in frontal lectures and journal club:
1) The knowledge provided by the program is presented in the lectures using ppt, images, diagrams and videos. The teaching is interactive, with questions and presentation of research studies (based on articles and reviews) to promote critical thinking and discussion in the classroom.
2) The Journal Club leads discussions on recent primary literature in all areas of the course
Additional notes about suggested reading: As supplementary materials, power point slides of all lectures, research paper and review will be available on https://elearning.unipd.it/biologia/. Recent scientific publication on international journal useful for the understanding of specific topics will be suggested.
Textbooks (and optional supplementary readings)
  • Lodish, Harvey F., Molecular cell biologyHarvey Lodish ... [et al.]. New York: W. H. Freeman, 2016. Cerca nel catalogo

Innovative teaching methods: Teaching and learning strategies
  • Lecturing
  • Case study
  • Interactive lecturing
  • Working in group
  • Use of online videos
  • Loading of files and pages (web pages, Moodle, ...)
  • Learning journal

Innovative teaching methods: Software or applications used
  • Moodle (files, quizzes, workshops, ...)
  • socrative

Sustainable Development Goals (SDGs)
Good Health and Well-Being