First cycle
degree courses
Second cycle
degree courses
Single cycle
degree courses
School of Science
Course unit
SCP5073118, A.A. 2019/20

Information concerning the students who enrolled in A.Y. 2018/19

Information on the course unit
Degree course Second cycle degree in
SC1177, Degree course structure A.Y. 2008/09, A.Y. 2019/20
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Number of ECTS credits allocated 8.0
Type of assessment Mark
Course unit English denomination BIOCHEMISTRY OF DISEASES
Website of the academic structure
Department of reference Department of Biology
Mandatory attendance
Language of instruction English
Single Course unit The Course unit can be attended under the option Single Course unit attendance
Optional Course unit The Course unit can be chosen as Optional Course unit

Teacher in charge LUCA SCORRANO BIO/10

Course unit code Course unit name Teacher in charge Degree course code

ECTS: details
Type Scientific-Disciplinary Sector Credits allocated
Core courses BIO/10 Biochemistry 8.0

Course unit organization
Period First semester
Year 2nd Year
Teaching method frontal

Type of hours Credits Teaching
Hours of
Individual study
Laboratory 2.0 32 18.0 No turn
Lecture 6.0 48 102.0 No turn

Start of activities 30/09/2019
End of activities 18/01/2020
Show course schedule 2019/20 Reg.2008 course timetable

Examination board
Board From To Members of the board
4 BIOCHIMICA DELLE PATOLOGIE 2019-2020 01/10/2019 27/11/2020 SCORRANO LUCA (Presidente)
GIACOMELLO MARTA (Membro Effettivo)
3 BIOCHIMICA DELLE PATOLOGIE 2018-2019 01/10/2018 30/11/2019 SCORRANO LUCA (Presidente)
GIACOMELLO MARTA (Membro Effettivo)

Prerequisites: Biochemistry, Physiology and Pathology
Target skills and knowledge: This course aims at giving to the student an overview of the frontier topics on the molecular and biochemical aspects of pathology. In particular, by using a combination of traditional lectures, seminars, small groups tutorials, Journal Clubs and practicals, the student will acquire specific abilities on the topics discussed during the course. Moreover, the course will allow the student to understand
1. how to build an experimental hypothesis in biomedicine
2. how to falsify this experimental hypothesis
3. how to critically evaluate a paper published in a major Journal
4. how to produce, analyze, present and critically discuss experimental results pertinent to the topics of this course.
Examination methods: Evaluation of the overall active participation to classes and tutorials (30%)
Evaluation of the lab report (30%)
Evaluation of the final public presentation (40%)
Assessment criteria: We will evaluate the individual contribution during the course (30%), the lab reports (30%), the essays produced during the course and the final exam (10%)
Course unit contents: 1. Introduction to the course

2. Mechanisms of protein homeostasis
3. Mechanisms of cellular ion homeostasis
4. Mechanisms of redox homeostasis and cellular bioenergetics
5. Biochemical mechanisms of reversible cellular damage
a. atrophy
b. hypertrophy
c. Metaplasia (EMT)
6. Biochemical mechanisms of irreversible cellular damage
a. apoptosis
b. necrosis
c. necroptosis
d. Autosis
7. Biochemical mechanisms of senescence and aging
8. Biochemical mechanisms of cell transformation and oncogenesis
9. Role of biochemistry in mitochondrial disease

These topics will be covered in specific workshops, Journal Clubs, lectures held by the teacher and by ad-hoc invited international experts.

Laboratory tutorials on biochemical assays of cell death and autophagy and on the analysis of mitochondrial dysfunction
Planned learning activities and teaching methods: Lectures and practicals
Additional notes about suggested reading: Articles and reviews that will be distributed
Textbooks (and optional supplementary readings)

Innovative teaching methods: Teaching and learning strategies
  • Laboratory
  • Problem based learning
  • Interactive lecturing
  • Working in group
  • Questioning
  • Problem solving
  • Flipped classroom
  • Peer feedback

Sustainable Development Goals (SDGs)
Good Health and Well-Being