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Course unit
CELL AND ORGAN PHYSIOLOGY AND MEDICAL PATHOPHYSIOLOGY
MEO2045676, A.A. 2018/19
Information concerning the students who enrolled in A.Y. 2018/19
ECTS: details
Type |
Scientific-Disciplinary Sector |
Credits allocated |
Core courses |
BIO/09 |
Physiology |
2.0 |
Core courses |
BIO/18 |
Genetics |
2.0 |
Core courses |
MED/04 |
General Pathology |
2.0 |
Core courses |
BIO/09 |
Physiology |
2.0 |
Course unit organization
Period |
Second semester |
Year |
1st Year |
Teaching method |
frontal |
Type of hours |
Credits |
Teaching hours |
Hours of Individual study |
Shifts |
Lecture |
8.0 |
64 |
136.0 |
No turn |
Start of activities |
25/02/2019 |
End of activities |
14/06/2019 |
Examination board
Board |
From |
To |
Members of the board |
6 Commissione 2018/19 |
01/10/2018 |
30/09/2019 |
MUCIGNAT
CARLA
(Presidente)
PIOVAN
ERICH
(Membro Effettivo)
RUSSO
ANTONELLA
(Membro Effettivo)
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Prerequisites:
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In order to take advantage from the topics of the course, the student should be familiar with the fundamental principles of Physics, Biology, Anatomy, Biochemistry, Genetics and general Physiology. |
Target skills and knowledge:
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Module I - Physiology: The goal is to make the student able to understand the basic functioning mechanisms of the human body in physiologic conditions, and of the homeostatic mechanisms that allow regulation and adaptation of organ activity to the environmental challenges.
Module II - The cellular response to DNA damage and repair:
A second goal is to make students familiar with the main molecular processes involved in genome maintenance, which safeguard the correct functionality of both dividing and non-dividing cells.
Module III - Signaling pathways deregulated in cancer: The aim of this module is to give adequate knowledge on the mechanisms responsible for aberrant activation of signaling pathways implicated in tumorigenesis and consequent potential therapeutic implications. |
Examination methods:
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Oral examination. |
Assessment criteria:
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Students should know the basic cellular, physiological and pathological mechanisms and their relationships. We will evaluate the ability to answer completely and accurately. |
Course unit contents:
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Module I: how the body survive to challenges.
Homeostatic mechanisms to environmental challenges.
Physiological responses to stress.
Aging.
Module II: The cellular response to DNA damage and repair.Molecular pathways activated in the presence of bulk lesions, double-strand or single-strand breaks, DNA crosslinks.Replication stress, oxidative stress, telomere dysfunction. Cell senescence, apoptosis.Polyploidy and cell transformation.
Module III: signaling pathways aberrantly activated in tumors, with a focus on haematological malignancies |
Planned learning activities and teaching methods:
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Academic lectures and seminars. |
Additional notes about suggested reading:
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Module I: Text and articles will be given during lectures. Any Physiology textbook for recalling main concepts.
Module II and III: scientific reviews and selected book chapters. |
Textbooks (and optional supplementary readings) |
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Innovative teaching methods: Teaching and learning strategies
- Lecturing
- Laboratory
- Problem based learning
- Case study
- Interactive lecturing
- Working in group
- Questioning
- Problem solving
- Loading of files and pages (web pages, Moodle, ...)
Innovative teaching methods: Software or applications used
- Moodle (files, quizzes, workshops, ...)
Sustainable Development Goals (SDGs)
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