First cycle
degree courses
Second cycle
degree courses
Single cycle
degree courses
School of Engineering
Course unit
INP4062715, A.A. 2018/19

Information concerning the students who enrolled in A.Y. 2018/19

Information on the course unit
Degree course Second cycle degree in
IN0532, Degree course structure A.Y. 2011/12, A.Y. 2018/19
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Number of ECTS credits allocated 6.0
Type of assessment Mark
Course unit English denomination BIOMATERIALS AND BIOLOGICAL TISSUES
Department of reference Department of Information Engineering
E-Learning website
Mandatory attendance No
Language of instruction Italian
Single Course unit The Course unit can be attended under the option Single Course unit attendance
Optional Course unit The Course unit can be chosen as Optional Course unit

Teacher in charge ANDREA BAGNO ING-IND/34

Course unit code Course unit name Teacher in charge Degree course code

ECTS: details
Type Scientific-Disciplinary Sector Credits allocated
Core courses ING-IND/34 Industrial Bioengineering 6.0

Course unit organization
Period First semester
Year 1st Year
Teaching method frontal

Type of hours Credits Teaching
Hours of
Individual study
Lecture 6.0 48 102.0 No turn

Start of activities 01/10/2018
End of activities 18/01/2019
Show course schedule 2019/20 Reg.2011 course timetable

Examination board
Board From To Members of the board
7 A.A. 2019/2020 01/10/2019 15/03/2021 BAGNO ANDREA (Presidente)
TODROS SILVIA (Membro Effettivo)
PAVAN PIERO (Supplente)
6 A.A. 2018/2019 01/10/2018 15/03/2020 BAGNO ANDREA (Presidente)
TODROS SILVIA (Membro Effettivo)
PAVAN PIERO (Supplente)
5 A.A. 2017/2018 01/10/2017 15/03/2019 BAGNO ANDREA (Presidente)
DETTIN MONICA (Membro Effettivo)
PAVAN PIERO (Supplente)

Prerequisites: The course includes the following prerequisites: elements of general chemistry, organic chemistry, biochemistry and biomaterials.
Target skills and knowledge: Students are expected to acquire the following knowledge:
1) main processes regulating the interactions between the surface of an implant device and the surrounding biological environment (coagulation, inflammation, possible infection, remodeling, integration);
2) methods to favor and improve these interactions (biochemical functionalization of surfaces);
3) recent applications of tissue engineering to regenerative medicine for the replacement of tissues/organs with engineered tissues/organs.
Students are also expected to acquire the following skills:
1) the ability to express a documented evaluation of the materials to be used for the realization of prosthetic devices, also obtained with tissue engineering techniques;
2) the ability to propose surface functionalization techniques.
Examination methods: Regular students are given the opportunity to take two written tests in itinere (compitini), each on half of the program. The mark obtained, which is awarded by rewarding the best students’ performance, is then recorded immediately after the end of the course.
All students are given the opportunity to take the oral exam on the entire program during the official appeals.
Assessment criteria: The preparation of the students is evaluated on the basis of their ability to analytically discuss the topics developed during the lessons, taking into account in particular:
- completeness of the exposure;
- lexicon.
Course unit contents: Introduction to the course. General concepts. Modern approach to the study of biomaterials. Regenerative medicine. Tissue engineering: preliminary considerations.
Examples of tissue replacement: skin, cartilage, blood vessels, heart valves.
Metallic materials: general aspects and applications.
Polymeric biomaterials: general aspects and applications.
Ceramic biomaterials: general aspects and applications.
Composite biomaterials: general aspects and applications.
Interaction between proteins and surface. Protein adsorption.
Kinetic factors and mass transport governing protein adsorption.
Interactions between biomaterials and blood. Composition of the blood. Origin and role of blood cells. The process of coagulation: role of platelets.
The intrinsic and extrinsic blood coagulation process. Anticoagulants. The design of biomaterials and biomedical devices as a function of the interaction with blood: the case of vascular grafts, oxygenators, ventricular assist devices, heart valves.
The process of inflammation: redness, swelling, pain and heat. Role of non-lymphoid leukocytes. Tissue macrophages, neutrophils and monocyte-macrophages.
Chemotaxis. Phagocytosis. Opsonization. Diapedesis. Infection: immediate and delayed.
Kinetic model of platelet adhesion.
Immune system. Immunity: innate and acquired. Humoral and cell-mediated. Role of B lymphocytes and T-lymphocytes. Immunogens, antigens and antibodies. The complement system.
Wound healing. Tissues and extra-cellular matrix. Hemostasis and inflammation. Proliferative phase. Outside-in and inside-out signaling. Angiogenesis. Granulation tissue and scar tissue. Remodeling.
Chronic wounds. Using hyaluronic acid in healing ulcers.
Healing around an implant device. Frustrated phagocytosis. Formation of fibrotic capsule in relation to the properties of the device. Complications. Cytotoxicity and immunotoxicity.
Carcinogenesis due to foreign body.
Biochemical functionalization: adsorption of biomolecules, covalent bond and release from carrier.
Experimental work for the determination osteoblasts adhesion in vitro and in vivo.
Biomolecules of interest, peptide mimicry. Cell-cell adhesion, cell-ECM adhesion. Functions of cell membrane. Cell membrane proteins. Functions and composition of the ECM. ECM proteins.
Growth factors: case studies.
Biocompatibility assessment.
The reconstruction of tissue engineered heart valves.
Mass transport phenomena in biological systems. Oxygen consumption and transport in biological systems. Michaelis-Menten’s equation. Henry's Law. Balance equation. Stokes-Einstein’s law. First and second Fick's laws. Thiele’s modulus.
Design of bio-artificial constructs extra-vascular implants. Diffusive-convective processes.
Krogh’s model.
Planned learning activities and teaching methods: - The program is mainly carried out through lectures and seminars. In this way the knowledge that students must acquire is proposed.
- Learning objectives are also achieved through the common discussion of some specific topics. The presentation of several "case studies" aims to encourage the participation of students in the discussion, also through group work. In this way the acquisition of specific skills is achieved.
Additional notes about suggested reading: The following reference text is proposed to the students:
- Carlo Di Bello and Andrea Bagno, Biomaterials (second edition). Bologna: Patron Editore, 2016.
Additional materials will be provided to students through Moodle.
Textbooks (and optional supplementary readings)
  • Carlo Di Bello e Andrea Bagno, Biomateriali (seconda edizione). Bologna: Patron Editore, 2016. Cerca nel catalogo
  • Riccardo Pietrabissa, Biomateriali per protesi e organi artificiali. Bologna: Patron Editore, 1996. Cerca nel catalogo
  • James F. Shackelford, Scienza e ingegneria dei materiali. --: Pearson Prentice Hall, 2009. Cerca nel catalogo

Innovative teaching methods: Teaching and learning strategies
  • Problem based learning
  • Case study
  • Working in group
  • Questioning
  • Video shooting made by the teacher/the students

Innovative teaching methods: Software or applications used
  • Moodle (files, quizzes, workshops, ...)
  • Kaltura (desktop video shooting, file loading on MyMedia Unipd)