First cycle
degree courses
Second cycle
degree courses
Single cycle
degree courses
School of Science
Course unit
SCP4068163, A.A. 2019/20

Information concerning the students who enrolled in A.Y. 2017/18

Information on the course unit
Degree course First cycle degree in
SC1166, Degree course structure A.Y. 2015/16, A.Y. 2019/20
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Number of ECTS credits allocated 7.0
Type of assessment Mark
Course unit English denomination GENETICS 2
Website of the academic structure
Department of reference Department of Biology
E-Learning website
Mandatory attendance
Language of instruction Italian


Integrated course for this unit
Course unit code Course unit name Teacher in charge

ECTS: details
Type Scientific-Disciplinary Sector Credits allocated
Educational activities in elective or integrative disciplines BIO/18 Genetics 7.0

Course unit organization
Period First semester
Year 3rd Year
Teaching method frontal

Type of hours Credits Teaching
Hours of
Individual study
Laboratory 1.0 16 9.0 No turn
Lecture 6.0 48 102.0 No turn

Start of activities 30/09/2019
End of activities 18/01/2020
Show course schedule 2019/20 Reg.2015 course timetable

Examination board
Examination board not defined


Common characteristics of the Integrated Course unit

Prerequisites: Propaedeutic courses are all those characterizing the first and second year of the Degree in Molecular Biology (in particular Genetics I, Genetic engineering, and Molecular Biology I.
Target skills and knowledge: Specific skills and knowledges in advanced genetics are supplied with particular reference to the following subjects: population genetics, molecular evolution, genomes organization., mobile genetic elements, extranuclear Inheritance, maternal Inheritance and maternal effects, genomic imprinting, mutations, DNA damage repair, recombination.
Examination methods: The examination is conducted in written form (exercises/problems and open questions). The individual report on the practical experience maturated during the laboratory training is also evaluated.
Assessment criteria: Student performances are evaluated on the basis of the following criteria:
1) knowledge and understanding of facts, concepts and principles
2) logic and methodological rigour
3) appropriate descriptive vocabulary is used

Specific characteristics of the Module

Course unit contents: Allele Frequencies and Genotype Frequencies, Allele Frequency Calculations, Enzyme Polymorphisms, DNA Polymorphisms, Random Mating and the Hardy-Weinberg Principle, Implications of the Hardy-Weinberg Principle, Frequency of Heterozygotes, Multiple Alleles, Differences among Populations, Inbreeding, Genetics and Evolution, Mutation and Migration, Irreversible Mutation, Reversible Mutation, Natural Selection, Components of Fitness, Selection-Mutation Balance, Heterozygote Superiority, Random Genetic Drift Microsatellites, minisatellites and DNA fingerprinting. Methods for the identification of genetic polymorphisms. Molecular evolution. Genome organization. Multigenic families, repeated sequences. Pseudogenes. Gene duplication. Gene conversion. Nucleotide substitution. Rates and mode of nucleotide substitution. Evolutionary rates of mitocondrial DNA. Non random usage of synonimous codons. Molecular clocks. Transposable elements, Insertion Sequences, Transposons in Bacteria, Transposons in Eucariotes, Human transposons, The P elements of Drosophila, horizontal gene transfer, The Transposons in Genetic Analysis. Extranuclear Inheritance: Recognition of Extranuclear Inheritance, Mitochondrial Genetic Diseases, Heteroplasmy, Maternal Inheritance and Maternal Effects, Organelle Heredity, The Genetic Codes of Organelles, Leaf Variegation in Four-O'clock Plants, Drug Resistance in Chlamydomonas, Respiration-Defective Mitochondrial Mutants, Cytoplasmic Male Sterility in Plants, The Evolutionary Origin of Organelles, Maternal Effect in Snail-Shell Coiling, Genomic imprinting. General Properties of Mutations, The Molecular Basis of Mutation, Base Substitutions, Insertions and Deletions, Transposable-Element Mutagenesis, Spontaneous Mutations, The Nonadaptive Nature of Mutation, Measurement of Mutation Rates, Hot Spots of Mutation, Induced Mutations, Base-Analog Mutagens, Chemical Agents That Modify DNA, Misalignment Mutagenesis, Ultraviolet Irradiation, Ionizing Radiation, Mechanisms of DNA Repair, Mismatch Repair, Photoreactivation, Excision Repair, Postreplication Repair, The SOS Repair System, Reverse Mutations and Suppressor Mutations, Intragenic Suppression, Intergenic Suppression, Reversion as a Means of Detecting Mutagens and Carcinogens, Recombination, The Holliday Model, Asymmetrical Single-Strand Break Model, Double-Strand Break Model.
Planned learning activities and teaching methods: The course consists of 16 h of laboratory and 48 h of lecture, for a total of 64 contact hours.
Laboratory training: practical laboratory sessions are organised to define the DNA profiles of participants.
Additional notes about suggested reading: Didactic materials for individual work and reading are available on the e-learning platform (https//
Textbooks (and optional supplementary readings)
  • Binelli, Giorgio; Ghisotti, Daniela; Aceto, Serena, Genetica[coordinatori] Giorgio Binelli, Daniela Ghisottiautori: Serena Aceto ... [et al.]. Napoli: EdiSes, 2018. consigliato Cerca nel catalogo
  • Pierce, Benjamin A.; Barbujani, Guido, GeneticaBenjamin A. Piercea cura di Guido Barbujani. Bologna: Zanichelli, 2016. consigliato Cerca nel catalogo