First cycle
degree courses
Second cycle
degree courses
Single cycle
degree courses
School of Science
BIOTECHNOLOGY
Course unit
PHARMACEUTICAL IMMUNOLOGY
SCP4065418, A.A. 2019/20

Information concerning the students who enrolled in A.Y. 2017/18

Information on the course unit
Degree course First cycle degree in
BIOTECHNOLOGY
IF1839, Degree course structure A.Y. 2011/12, A.Y. 2019/20
N0
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Number of ECTS credits allocated 6.0
Type of assessment Mark
Course unit English denomination PHARMACEUTICAL IMMUNOLOGY
Website of the academic structure https://biotecnologie.biologia.unipd.it/lt-biotecnologie/
Department of reference Department of Biology
Mandatory attendance
Language of instruction Italian
Branch PADOVA
Single Course unit The Course unit can be attended under the option Single Course unit attendance
Optional Course unit The Course unit can be chosen as Optional Course unit

Lecturers
Teacher in charge ANTONIO ROSATO MED/04
Other lecturers SUSANNA MANDRUZZATO MED/04

ECTS: details
Type Scientific-Disciplinary Sector Credits allocated
Educational activities in elective or integrative disciplines MED/04 General Pathology 6.0

Course unit organization
Period Second semester
Year 3rd Year
Teaching method frontal

Type of hours Credits Teaching
hours
Hours of
Individual study
Shifts
Lecture 6.0 48 102.0 No turn

Calendar
Start of activities 02/03/2020
End of activities 12/06/2020
Show course schedule 2019/20 Reg.2011 course timetable

Examination board
Board From To Members of the board
3 IMMUNOLOGIA FARMACEUTICA 2018-2019 01/10/2018 30/11/2019 ROSATO ANTONIO (Presidente)
MANDRUZZATO SUSANNA (Membro Effettivo)
ZANOVELLO PAOLA (Supplente)

Syllabus
Prerequisites: The student should have a basic knowledge in anatomy, biochemistry, cell biology and physiology.
Target skills and knowledge: The course aims at providing the student with knowledge about the organization of immune system (humoral and cellular elements), its functioning modalities (antigen recognition, response to pathogens, humoral and cellular effectors) and pharmacological interventions to foster its efficacy or to limit potential side-effects. Furthermore, the course aims at providing some basic elements of immunopathology (hypersensitivity reaction I-IV) and the related principles of therapeutic intervention.
Examination methods: Multiple choice written exam (indicatively, 50-60 questions).
Assessment criteria: The final examination aims at assessing the competence of the student as compared to the main objectives stated at the beginning of the course.
Course unit contents: General characteristics of the immune system.
Cells, organs and microenvironment of the immune system.
Principles of innate and adaptive immunity.
Innate immunity. The different lines of defense and the systems of pathogen identification by cells of innate immunity: PAMPs, DAMPs, and PRR. Toll-like receptors. Cytosolic receptors for PAMP and DAMP. The inflammasome and the development of drugs capable of interacting as antagonists in inflammation.
Cells of immune system. Hemopoiesis: origin, regulation, growth factors.
Totipotent stem cells, progenitor cells and differentiated cells.
Antigens and their characteristics, antigens and antibodies. Molecular structure of antibodies. Polyclonal and monoclonal antibodies. Development of monoclonal antibodies, their molecular evolution and use as drugs.
Primary and secondary humoral response. Thymus-dependent and independent antigens.
B cell activation and antibody production.
Effector mechanisms of humoral immunity: neutralization, opsonization and phagocytosis.
The complement system: organization and functions of classical and alternative pathways. Fc and complement receptors in opsonization and phagocytosis.Immunocomplexes clearance.
Innate and adaptive immune responses to viral infections: role of IFN, NK cells, antibodies and CTL.
The Major Histocompatibility complex: genetic organization, nomenclature, structure and biological function of MHC molecules.
Serologic and molecular HLA typing; mixed leukocyte reaction (MLR).
Molecular genetics of the antigen receptor. Rearrangment of genes coding forthe antigen receptor in B and T cells. T and B lymphocyte maturation.
Functional responses of T cells: Th1, Th2, Th17 and Tregs.
Hypersensitivity reactions type I-IV.
Principles of vaccination, active and passive immunization, main types of vaccines and technology of production.
Therapeutic use of cytokines and immunomodulators of microbial origin.
Drugs used in the immunosuppressive therapy.
Prevention and therapy of allergic diseases and drug hypersensitivity.
Planned learning activities and teaching methods: Frontal and theorical-practical lessons.
Intermediate and final assessment of learning by multiple choice questionnarie.
Additional notes about suggested reading: Lectures notes and scientific articles.
Textbooks (and optional supplementary readings)
  • A. K. Abbas, A. H. Lichtman, S. Pillai., Immunologia cellulare e molecolare - 9 edizione.. --: EDRA, 2018. Cerca nel catalogo
  • K. Murphy, Immunobiologia di Janeway. --: Piccin, 2014. Cerca nel catalogo