First cycle
degree courses
Second cycle
degree courses
Single cycle
degree courses
School of Science
Course unit
SCP3056709, A.A. 2019/20

Information concerning the students who enrolled in A.Y. 2017/18

Information on the course unit
Degree course First cycle degree in
IF1839, Degree course structure A.Y. 2011/12, A.Y. 2019/20
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Number of ECTS credits allocated 7.0
Type of assessment Mark
Course unit English denomination IMMUNOLOGY
Website of the academic structure
Department of reference Department of Biology
Mandatory attendance
Language of instruction Italian
Single Course unit The Course unit can be attended under the option Single Course unit attendance
Optional Course unit The Course unit can be chosen as Optional Course unit

Teacher in charge EMANUELE PAPINI MED/04

ECTS: details
Type Scientific-Disciplinary Sector Credits allocated
Educational activities in elective or integrative disciplines MED/04 General Pathology 7.0

Course unit organization
Period Second semester
Year 3rd Year
Teaching method frontal

Type of hours Credits Teaching
Hours of
Individual study
Lecture 7.0 56 119.0 No turn

Start of activities 02/03/2020
End of activities 12/06/2020
Show course schedule 2019/20 Reg.2011 course timetable

Examination board
Board From To Members of the board
7 IMMUNOLOGIA 2019-2020 01/10/2019 27/11/2020 PAPINI EMANUELE (Presidente)
TAVANO REGINA (Membro Effettivo)
6 IMMUNOLOGIA 2018-2019 01/10/2018 30/11/2019 PAPINI EMANUELE (Presidente)
TAVANO REGINA (Membro Effettivo)
GORZA LUISA (Supplente)

Prerequisites: the student must have a good preparation in biochemistry, cell biology, hystology
Target skills and knowledge: Understanding the concepts, the cellular actions and the molecules of body defence against foreign agents. UNdertanding the main alterations of the cells and tissues.
Examination methods: written hexam
Assessment criteria: The acquisition of the notions object of the course and the ability to examine them in depth and to link them together.
Course unit contents: 1. the notion of noxa and disease
2. Cell pathology: the cell as the elementary patient. Number and size alterations. Intracellular accumulations (watery degeneration, lipidosis, glycogenosis). Alteration of intracellular organells. Oncosis, apoptosis, pyoptosis, NETosis, Mitotic catastrophe. NLR, inflammasomes.
3. Interstitial accumulations of molecules: amyloidosis, Alzheimer plaque. Necrosis, alterations of collagen, elastin and proteoglycans
4. Innate Immunity. Body surfaces, body interior, umoral and cellular
5. Tissue reactions to damage: inflammation. Vascular and cellular phases. Acute and chronic inflammation. Tissue repair and regeneration.
6.Mucosal immunity and its alterations (IBD)- relation between the SI and the gut microbioma-the role of inflammation in tumors and in obesity.
7. Adaptive immunity
introduction to the immune system: innate and adaptive. Immune cells and limphoyd tissues: primary and secondary. Antigens and epitopes: classification and chemical nature. Molecules of the immune system devoted to antigen binding: i) antibodies. general structure. Classes, sub-classes and their functions. Polymorphism. B cell receptor (BCR). Interaction with the innate immune system. ii) T cell Receptor (TCR). Structure and cell distribution. iii) MHC I and II. Genetic organisation and polimorphism. Generation of immuneglobuline and TCR diversity: molecular mechanisms. Antigen recognition.
Antigen-antibody interaction: molecular forces, affinity, avidity, kinetics. Antigen presentation. Antigen presenting cells (APC): properties and localisation in the body. APC-linphocytes interaction. Cytokine role.T-dependent and T-independent antigens and immunological answer.
Roles of the microbial (PAMPs) and danger (DAMPs)signals in the regulation of the innate and adaptive immunity.
Cell-mediated immunity.
Regulation of the immune response: antigenic, anticorpal, due to immune-complexes and operated by linphocytes.
Planned learning activities and teaching methods: Frontal lectures
Additional notes about suggested reading: Lecture notes and other materials provided by the teacher. A text-book of general Immunology
Suggested but not mandatory: Janeway, Immunobiology, Piccin ed (or other editors for the English versions)
Textbooks (and optional supplementary readings)
  • Janeway C.A e altri 8a edizione, Immunobiologia. Padova: Piccin, 2014. Cerca nel catalogo