First cycle
degree courses
Second cycle
degree courses
Single cycle
degree courses
School of Engineering
BIOENGINEERING
Course unit
MEDICAL BIOTECHNOLOGIES
INP6075697, A.A. 2018/19

Information concerning the students who enrolled in A.Y. 2017/18

Information on the course unit
Degree course Second cycle degree in
BIOENGINEERING
IN0532, Degree course structure A.Y. 2011/12, A.Y. 2018/19
N0
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Number of ECTS credits allocated 6.0
Type of assessment Mark
Course unit English denomination MEDICAL BIOTECHNOLOGIES
Department of reference Department of Information Engineering
E-Learning website https://elearning.dei.unipd.it/course/view.php?idnumber=2018-IN0532-000ZZ-2017-INP6075697-N0
Mandatory attendance No
Language of instruction English
Branch PADOVA
Single Course unit The Course unit can be attended under the option Single Course unit attendance
Optional Course unit The Course unit can be chosen as Optional Course unit

Lecturers
Teacher in charge ENRICO LAVEZZO MED/07

ECTS: details
Type Scientific-Disciplinary Sector Credits allocated
Educational activities in elective or integrative disciplines MED/07 Microbiology and Clinical Microbiology 6.0

Course unit organization
Period First semester
Year 2nd Year
Teaching method frontal

Type of hours Credits Teaching
hours
Hours of
Individual study
Shifts
Lecture 6.0 48 102.0 No turn

Calendar
Start of activities 01/10/2018
End of activities 18/01/2019

Examination board
Board From To Members of the board
2 A.A. 2018/2019 01/10/2018 15/03/2020 LAVEZZO ENRICO (Presidente)
TOPPO STEFANO (Membro Effettivo)
BARZON LUISA (Supplente)
1 A.A. 2017/2018 01/10/2017 15/03/2019 LAVEZZO ENRICO (Presidente)
BARZON LUISA (Membro Effettivo)
TOPPO STEFANO (Supplente)

Syllabus
Prerequisites: Basic knowledge of biology and physiology. In particular, knowledge about structure and function of DNA, RNA and protein syntesis in eukariotic and prokariotic cells is required.
Participation in this course is also recommended for those wishing to attend the "Computational Genomics" course (second year, second semester).
Target skills and knowledge: Basic information about the fundamental technologies applied in the field of medical biotechnologies:

1. molecular cloning
2. generation of genomic libraries
3. methods for DNA amplification and sequencing
4. whole genome sequencing
5. immunological techniques
6. gene editing
7. gene therapy
8. vaccine development
9. cell reprogramming and tissue engineering
10. application to diagnosis and therapy of human diseases of the previous methods

Part of the course will focus on bioinformatics aspects of biotechnologies:

1. alignment and assembly of sequences (DNA and proteins)
2. functional inference (post-genomics)

The student will have to demonstrate knowledge and understanding of the subject, showing the ability to synthetically expose the concepts and to generalize them.
Examination methods: Written exam, open questions with a synthetic answer.
This modality allows to evaluate both the acquired knowledge and the understanding, together with the ability to synthesize the concepts.
Assessment criteria: Students will be evaluated based on their understanding and competence regarding the proposed topics, besides the ability of generalization of concepts with critical thinking.
Course unit contents: 1: Basic technologies
- molecular cloning
- genomic libraries
- DNA amplification through PCR
- DNA sequencing methods
- whole genome sequencing
- DNA and protein alignment methods

2: Diagnosis and therapy of human diseases:
- molecular diagnosis
- immunological approaches to detect protein biomarkers of disease
- molecular approaches for disease diagnosis
- RNA detection as a method for disease diagnosis

3: Basic concepts in Immunology:
- immune response
- immune system functions
- types of antibodies: applications
- immunological techniques

4: Microbiology:
- bacteria
- viruses

5: Production of therapeutic agents:
- gene expression manipulation in prokaryotes
- production of heterologous proteins in eukaryotic cells
- site-specific mutagenesis
- genome editing
- mRNA and DNA specific targeting
- viral and non-viral systems for gene transfer
- gene therapy and applications

6: Vaccines:
- vaccination
- subunit vaccines
- DNA vaccines
- attenuated vaccines
- vaccine vectors

7: Cell therapy:
- stem cell biology
- stem cell reprogramming
- tissue engineering
Planned learning activities and teaching methods: The course introduces theoretical backgrounds through frontal lessons, which will be as interactive as possible to promote a high degree of participation from the students.
Additional notes about suggested reading: The teaching material will be exclusively in english. The slides of each lecture will be provided through the Moodle platform, together with scientific reviews on specific subjects.
Suggested textbook (which however only partially covers the course program): "Gene cloning and DNA analysis: an introduction", 7th edition (T. Brown) Wiley and Sons.
Textbooks (and optional supplementary readings)
  • Brown, Terence Austen, Gene cloning and DNA analysisan introductionT. A. Brown. Chichester: Wiley Blackwell, 2016. Cerca nel catalogo

Innovative teaching methods: Teaching and learning strategies
  • Lecturing
  • Case study
  • Questioning
  • Use of online videos
  • Loading of files and pages (web pages, Moodle, ...)

Innovative teaching methods: Software or applications used
  • Moodle (files, quizzes, workshops, ...)

Sustainable Development Goals (SDGs)
Good Health and Well-Being