First cycle
degree courses
Second cycle
degree courses
Single cycle
degree courses
School of Medicine
Course unit
MEP3053458, A.A. 2018/19

Information concerning the students who enrolled in A.Y. 2017/18

Information on the course unit
Degree course 6 years single cycle degree in
ME1730, Degree course structure A.Y. 2017/18, A.Y. 2018/19
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Number of ECTS credits allocated 6.0
Type of assessment Mark
Course unit English denomination MICROBIOLOGY
Department of reference Department of Neurosciences
Mandatory attendance
Language of instruction Italian
Single Course unit The Course unit CANNOT be attended under the option Single Course unit attendance
Optional Course unit The Course unit is available ONLY for students enrolled in SCHOOL OF DENTISTRY (Ord. 2017)

Teacher in charge ALFREDO GARZINO DEMO MED/07

ECTS: details
Type Scientific-Disciplinary Sector Credits allocated
Core courses MED/07 Microbiology and Clinical Microbiology 6.0

Course unit organization
Period First semester
Year 2nd Year
Teaching method frontal

Type of hours Credits Teaching
Hours of
Individual study
Lecture 6.0 72 78.0 No turn

Start of activities 01/10/2018
End of activities 18/01/2019
Show course schedule 2019/20 Reg.2017 course timetable

Examination board
Board From To Members of the board
7 MICROBIOLOGIA 01/10/2019 30/09/2020 GARZINO DEMO ALFREDO (Presidente)
6 MICROBIOLOGIA 01/10/2018 30/09/2019 GARZINO DEMO ALFREDO (Presidente)

Prerequisites: The student must have basic knowledge of cell biology, genetics and biochemistry.
Target skills and knowledge: At the end of the course, the student will learn fundamental facts about microbial agents, infectious diseases they transmit, microbial transmission pathways, hygiene, detergency and sterilization, antimicrobial drugs and pharmacoresistence.
Examination methods: Written exam with multiple-choice questions on the whle program.
Assessment criteria: The student will be evaluated based on the number of correct answers to the exam questions
Course unit contents: Introduction to General Microbiology.

- Microbes and humans. Microbial classification: viruses, bacteria, protozoa, mycetes, parasites, prions.
Micro-host reactions: parasitism, commensalism, mutualism. Microbial colonization.
-Principles of microbial pathogenicity.
- Transmission of infectious agents

-The bacteria: morphology and bacterial aggregate structures. Bacterial ultrastructure: capsule, pili and fimbrias, cell wall, ribosomes, chromosomal and extracellular DNA, flagellas and bacterial locomotion structures.
- Bacterial metabolism: Nutritional requirements in relation to the aerobic / anaerobic environment.
-The best spore: generation and germination of the spore. Characteristics of pathogenicity related to the sporulation.
- Bacterial toxins. Exotoxins and endotoxins. Tetanus and Botulinum Neurotoxins. Choleric toxins and enterotoxins. Anthracic toxins, diphtheria. Microbicidal superantigens. Adesine and invasion.

-Diagnosis laboratory of microbial infections: Gram, trichromatic, acid resistant. Cultures and microbial culture media. Selective media. Cell cultures and virus cultivation. Direct and indirect diagnostic systems. Serology. Molecular diagnosis and amplification of nucleic acids. Specificity and sensitivity. Qualitative and quantitative diagnostic value. Common errors in Infection Diagnosis

- Microbes, anatomical defenses, unspecified defenses, innate and adaptive immune system.

-Sera and vaccines. Principles of prophylaxis and prevention.

- Antibiotics: classification, structure, action spectrum, bacteriostatic / bactericidal action. Targeted antibiotics and toxicity. Association between antibiotic drugs: principles and effects.
- Microbial resistance to antibiotic drugs: diffusion, consequences and molecular mechanism of diffusion of nosocomial resistance. Microbial genetics: conjugation, transformation, transduction. The susceptibility.

- Viruses: general and structural characteristics and Baltimore classification. The viral replication cycle.
- Viruses and carcinogenesis.

Antiviral drugs: general characteristics and specificity. Resistance to antiviral drugs.

-Transmission, pathogenesis, tropism and prevention of pathogenic human viruses: HIV, HPV, hepatitis virus. Enteric viruses, herpesviruses, respiratory viruses. Viruses transmitted by arthropode vectors.
Congenital, perinatal and postnatal infections
- Sexually transmitted infections
-IExanthematic infections of childhood
-Respiratory infections. Pulmonary and extrapulmonary TB
-Infections transmitted by insects and ticks: TBE, Lyme borrellosis, West Nile Virus, Zika and other emerging infections. Malaria.

- Bacterial and viral infections of the central nervous system. Prions and neurodegenerative infections.

- Mycetic morphological-structural features and fungal infections. Fungal superficial infections and deep infections. Antifungal drugs and their action.

-Protozoi and parasites: Morphological-structural features. Antiprotozoal and antiparasitic drugs.

-Microbial of the oral cavity. Microbial biofilms. Microbiological aspects of caries, plaque, tartar, gingivitis, stomatitis, abscesses.

Antimicrobial Therapies: Empirical Guidelines. Mouth microbes, endocarditis, bone infections, cerebral abscesses.
Planned learning activities and teaching methods: Learning is based on traditional lessons, and on discussions on current topics or to be deepened.
Additional notes about suggested reading: In class slides.
Textbooks (and optional supplementary readings)
  • Murray, Patrick R.; Rosenthal, Ken S.; Di_Francesco, Paolo; Angiolella, Letizia, Microbiologia medicaPatrick R. Murray, Ken S. Rosenthal, Michael A. Pfalleredizione italiana a cura di Paolo Di FrancescoLetizia Angiolella ... [et al.]. Milano: Edra, Masson, 2013. Cerca nel catalogo