First cycle
degree courses
Second cycle
degree courses
Single cycle
degree courses
School of Medicine
PHARMACY
Course unit
BIOCHEMISTRY AND MEDICAL BIOCHEMISTRY
FAO2043751, A.A. 2018/19

Information concerning the students who enrolled in A.Y. 2017/18

Information on the course unit
Degree course 5 years single cycle degree in
PHARMACY (Ord. 2009)
FA1732, Degree course structure A.Y. 2009/10, A.Y. 2018/19
N0
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Number of ECTS credits allocated 10.0
Type of assessment Mark
Course unit English denomination BIOCHEMISTRY AND MEDICAL BIOCHEMISTRY
Department of reference Department of Pharmaceutical and Pharmacological Sciences
Mandatory attendance No
Language of instruction Italian
Branch PADOVA
Single Course unit The Course unit can be attended under the option Single Course unit attendance
Optional Course unit The Course unit can be chosen as Optional Course unit

Lecturers
Teacher in charge DIEGO DE STEFANI BIO/10

ECTS: details
Type Scientific-Disciplinary Sector Credits allocated
Core courses BIO/10 Biochemistry 10.0

Course unit organization
Period First semester
Year 2nd Year
Teaching method frontal

Type of hours Credits Teaching
hours
Hours of
Individual study
Shifts
Lecture 10.0 80 170.0 No turn

Calendar
Start of activities 01/10/2018
End of activities 18/01/2019

Examination board
Board From To Members of the board
6 Commissione a.a. 2018/19 03/12/2018 30/09/2019 DE STEFANI DIEGO (Presidente)
CALI' TITO (Membro Effettivo)

Syllabus
Prerequisites: This class requires basic knowledge of general, inorganic and organic chemistry, as well as of biology. All the prerequisites are provided by the courses attended during the first year.
Target skills and knowledge: Students will acquire a detail knowledge of biological-relevant molecules and biochemical processes that are relevant to the physiopathology of major organs.
Examination methods: Written exam. The test will include six open-ended questions to be answered in 2 hours. The exam is aimed to understand whether the student has understood the structure and function of biomolecules and how enzymatic reactions are controlled. In addition, the student has to demonstrate to be proficient in the knowledge of metabolic pathways and signal transduction mechanisms that control their regulation.
Assessment criteria: Each answer will be scored from zero to five. The final grade is the sum of individual answers, which will be evaluated in terms of i) clarity, ii) relevance/significance, iii) depth/breadth and iv) accuracy.
Course unit contents: This class is aimed to describe and understand the structure and function of biomedical-relevant molecules. In addition, we will learn how biochemical reactions transform these molecules in physiological and pathological conditions. The class is subdivided in two different but intertwined modules:
1. Biochemistry
Structure and function of biological molecules: carbohydrates, lipids, proteins and nucleic acids. Structure/function relationship in proteins: hemoglobin, collagen and immunoglobulin as paradigmatic cases.
Enzymology: structure, function and kinetics of enzymes; regulation of enzymatic activity; allosteric enzymes; clinical enzymology; vitamins and coenzymes.
Metabolism and bioenergetics: mitochondria, electron transport chain and oxidative phosphorylation; Non-mitochondrial electron transport chains (peroxisomes and microsomes); cytochrome P450; synthesis of nitric oxide; carbohydrates metabolism, including glycolysis, gluconeogenesis, glycogen synthesis and degradation, TCA cycle, and pentose phosphate pathway; lipid metabolism, including beta-oxidation, ketone bodies synthesis and utilization, phospholipid biosynthesis, cholesterol metabolism. Amino acids metabolism: deamination, transamination and decarboxylation; urea cycle; Heme metabolism. Nucleic acid metabolism.
2. Clinical biochemistry
Blood and antibodies. Vitamin K and clotting cascade. Atherosclerosis and lipoproteins. Integration and hormonal regulation of whole body metabolism: insulin, glucagon, phosphoinositide, catecholamine and thyroid hormones. Steroid hormones. Metabolism of arachidonic acid. Signal transduction through G-protein coupled receptors (cAMP, cGMP, IP3) and tyrosine kinase receptors. Tissue-specific biochemistry, including heart, skeletal muscle, brain, liver, kidney and connective tissue.
Planned learning activities and teaching methods: Conventional teaching through standard lectures with the support of powerpoint slides.
Additional notes about suggested reading: In addition to the suggested textbook, pdf slides used during the lectures will be available through the Moodle platform. Whenever needed, the teacher will provide additional notes to integrate textbook limitations. Additional material (links, paper, software) will be available through Moodle platform
Textbooks (and optional supplementary readings)
  • Lehninger, Albert L.; Nelson, David L., <<I >>principi di biochimica di LehningerDavid L. Nelson, Michael M. Coxedizione italiana [e revisione] a cura di Edon Melloni e Franca Salamino. Bologna: Zanichelli, 2014. Cerca nel catalogo
  • Devlin, Thomas M.; Simmaco, Maurizio; Abruzzese Saccardi, Alberto, Biochimica con aspetti clinico-farmaceuticiThomas M. Devlin[aggiornato sulla 5. ed italiana a cura di Alberto Abruzzese Saccardi ... et al.]. Napoli: EDISES, 2013. Cerca nel catalogo
  • Siliprandi, Noris; Tettamanti, Guido; Avigliano, Luciana, Biochimica medicastrutturale, metabolica e funzionaleSiliprandi & Tettamanti. Padova: Piccin, 2014, --. Cerca nel catalogo

Innovative teaching methods: Teaching and learning strategies
  • Loading of files and pages (web pages, Moodle, ...)

Innovative teaching methods: Software or applications used
  • Moodle (files, quizzes, workshops, ...)

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