| First cycle degree courses | Second cycle degree courses | Single cycle degree courses |
| School of Science | ||
| BIOTECHNOLOGY | ||
Course unit
GENERAL PHARMACOLOGY AND TOXICOLOGY
SCP3056621, A.A. 2018/19
Information concerning the students who enrolled in A.Y. 2016/17
GENERAL PHARMACOLOGY AND TOXICOLOGY
SCP3056621, A.A. 2018/19
Information concerning the students who enrolled in A.Y. 2016/17
Information on the course unit
| Degree course |
First cycle degree in BIOTECHNOLOGY IF1839, Degree course structure A.Y. 2011/12, A.Y. 2018/19 |
 bring this page with you |
|---|---|---|
| Number of ECTS credits allocated | 8.0 | |
| Type of assessment | Mark | |
| Course unit English denomination | GENERAL PHARMACOLOGY AND TOXICOLOGY | |
| Website of the academic structure | https://biotecnologie.biologia.unipd.it/index.php?id=113 | |
| Department of reference | Department of Biology | |
| Mandatory attendance | Sì | |
| Language of instruction | Italian | |
| Branch | PADOVA | |
| Single Course unit | The Course unit can be attended under the option Single Course unit attendance | |
| Optional Course unit | The Course unit can be chosen as Optional Course unit |
Lecturers
| Teacher in charge | PATRIZIA DEBETTO | BIO/14 | |
|---|---|---|---|
| Other lecturers | GENNY ORSO | BIO/14 |
Mutuated
| Course unit code | Course unit name | Teacher in charge | Degree course code |
|---|---|---|---|
| SCP3056677 | PHARMACOLOGY AND INTRODUCTORY PHARMACOGENOMICS | PATRIZIA DEBETTO | IF1839 |
ECTS: details
| Type | Scientific-Disciplinary Sector | Credits allocated | |
|---|---|---|---|
| Educational activities in elective or integrative disciplines | BIO/14 | Pharmacology | 8.0 |
Course unit organization
| Period | Second semester |
|---|---|
| Year | 3rd Year |
| Teaching method | frontal |
| Type of hours | Credits | Teaching hours |
Hours of Individual study |
Shifts |
|---|---|---|---|---|
| Laboratory | 1.0 | 16 | 9.0 | No turn |
| Lecture | 7.0 | 56 | 119.0 | No turn |
Examination board
| Board | From | To | Members of the board |
|---|---|---|---|
| 6 FARMACOLOGIA GENERALE E TOSSICOLOGIA 2018-2019 | 01/10/2018 | 30/11/2019 |
DEBETTO
PATRIZIA
(Presidente)
ORSO GENNY (Membro Effettivo) GIRON MARIA CECILIA (Supplente) |
| 5 FARMACOLOGIA GENERALE E TOSSICOLOGIA 2017/2018 | 01/10/2017 | 25/11/2018 |
DEBETTO
PATRIZIA
(Presidente)
ORSO GENNY (Membro Effettivo) ZUSSO MORENA (Supplente) |
| Prerequisites: | Good knowledge of human physiology and biological chemistry |
| Target skills and knowledge: | The purpose of this course is to provide students with a basic understanding of: 1) principles regulating drug-organism interaction, including the pharmacodynamics (mechanism of drug action) and pharmacokinetics (absorption, distribution, and elimination); 2) principles of general Toxicology, including types of xenobiotic toxic effects and their onset conditions |
| Examination methods: | oral exam |
| Assessment criteria: | The student ability to critically and crosswise debate asked issues, topic skill, and scientific language will be evaluated |
| Course unit contents: | Introduction to Pharmacology
• Definition and aims of Pharmacology; drug definition and sources; chemical and biotechnological drugs • Drugs and specialties; drug classification systems Pharmacodynamics • Mechanism of drug action, non specific versus specific • Molecular targets for drug action (receptors) • Quantitative aspects of drug-receptor interaction: theoretical relationship between occupancy and drug concentration; definition of affinity • From drug-receptor interaction to the effect; the receptor-occupancy theory and its modifications; graded dose-effect curve; definition of drug potency and efficacy • Definition of full agonist, partial agonist, inverse agonist, and antagonist; mechanisms of drug antagonism • Quantal dose-response curve; definition of drug selectivity and safety; therapeutic indices • Molecular structure and signal transduction of the main super-families of receptors for endogenous ligands: intracellular receptors; ligand-gated ion channel; G-protein-coupled receptors; tyrosin-kinase-linked receptors; cell adhesion receptors • Receptor adaptation mechanisms (desensitization, down- and upregulation) and their pharmacological consequences (tolerance, dependency; rebound effects) Qualitative pharmacokinetics • Ways by which drugs cross cell membranes • Routes of drug administration; absorption; bioavailability • Distribution; placental and blood-brain barrier • Biotransformation: phase I and II reactions; detoxification versus bioactivation • Environmental factors affecting drug biotransformation: enzyme induction and inhibition • Renal and biliary excretion Elements of pharmacogenetics • Genetic factors underlying the biological inter-individual variability in drug response • Polymorphisms in genes encoding drug receptors and drug biotransforming enzymes Principles of general Toxicology • Definition and aims of Toxicology; toxicant definition • Types of toxic effects: acute and chronic effects; reversible and irreversible effects; local and systemic effects • Special toxic effects: teratogenic, idiosyncrasic, and genotoxic effects • Immunotoxicity: allergic and autoimmune reactions; immunosuppression • Adverse drug reactions (ADR): type A and B reactions Research and development of new drugs |
| Planned learning activities and teaching methods: | traditional frontal lessons |
| Additional notes about suggested reading: | Lecture pdf files |
| Textbooks (and optional supplementary readings) |
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