First cycle
degree courses
Second cycle
degree courses
Single cycle
degree courses
School of Medicine
Course unit
MEO2045680, A.A. 2016/17

Information concerning the students who enrolled in A.Y. 2016/17

Information on the course unit
Degree course Second cycle degree in
ME1934, Degree course structure A.Y. 2012/13, A.Y. 2016/17
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Degree course track MEDICAL BIOTECHNOLOGIES [002PD]
Number of ECTS credits allocated 8.0
Type of assessment Mark
Course unit English denomination IMMUNOLOGY AND GENERAL PATHOLOGY
Department of reference Department of Molecular Medicine
Mandatory attendance No
Language of instruction English
Single Course unit The Course unit CANNOT be attended under the option Single Course unit attendance
Optional Course unit The Course unit is available ONLY for students enrolled in MEDICAL BIOTECHNOLOGIES

Teacher in charge LUISA GORZA MED/04
Other lecturers ANTONIO ROSATO MED/04

ECTS: details
Type Scientific-Disciplinary Sector Credits allocated
Core courses MED/04 General Pathology 6.0
Core courses MED/08 Pathological Anatomy 2.0

Course unit organization
Period Second semester
Year 1st Year
Teaching method frontal

Type of hours Credits Teaching
Hours of
Individual study
Lecture 8.0 64 136.0 No turn

Start of activities 27/02/2017
End of activities 09/06/2017
Show course schedule 2019/20 Reg.2012 course timetable

Examination board
Board From To Members of the board
7 Commissione 2019/2020 01/10/2019 30/10/2020 GORZA LUISA (Presidente)
ROSATO ANTONIO (Membro Effettivo)
6 Commissione 2018/19 01/10/2018 30/09/2019 GORZA LUISA (Presidente)
ROSATO ANTONIO (Membro Effettivo)
5 Commissione 2017/18 01/10/2017 30/09/2018 GORZA LUISA (Presidente)
ROSATO ANTONIO (Membro Effettivo)
4 Commissione 2016/17 01/10/2016 30/09/2017 GORZA LUISA (Presidente)
ROSATO ANTONIO (Membro Effettivo)

Prerequisites: Students are expected to know major processes in Cell Biology, Physiology, Immunology and General Pathology (cell death, inflammation, oncology).
Target skills and knowledge: The course is composed by two parts, Immunology and General Pathology.
The Immunology part will be an extension of the basic course in Immunology presenting in-depth analysis of the pathological aspects of the immune response. In particular, it will cover mechanisms and features of hypersensitivity reactions, transplantation immunity, and immunodeficiencies. Particular emphasis will be given to manipulative aspects of immune response, such as i) vaccination and vaccines (with a special focus on cancer vaccines), ii) development and clinical use of monoclonal antibodies, and iii) generation , expansion and redirection of T cells for therapeutic purposes. Finally, particular attention will be paid to current approaches utilizing in vivo molecular imaging for drug and immune response study. At the end of the course the Student should: i) be able to describe a pathological immune response and recognize the operating immunological mechanisms; ii) be aware of biotechnological potentialities connected to the manipulation of the immune response for therapeutic purposes.
The part of General Pathology will feature recently recognized mechanisms involved in cellular adaptive responses (such as atrophy, hypertrophy, cell stress response) and their involvement in the pathogenesis of major human diseases, such as diabetes, neurodegenerative diseases, atherosclerosis, heart failure and muscle atrophy. Furthermore, features of biotechnological interest concerning inflammation, cancer and reparative processes will be addressed. Students are expected to participate actively to the course. On voluntary basis and under supervision, they will present and discuss recent experimental literature addressing some course topics and leading to the identification of new signalling pathways and/or other aspects of potential biotechnological interests (drug and biomarker development).
At the end of the course the student should: i) know main signalling pathways involved in the pathogenesis of major human diseases; ii) be aware about current and possible biotechnological approaches aimed to ameliorate prevention, diagnosis and therapy; iii) be prepared for critical reading of the literature.
Examination methods: Written examination (open answer test). Additional evaluation will be summed to the credit acquired with the regular examination, on voluntary basis, for the reading and presentation of a research article from the literature.
Assessment criteria: Evaluation will consider student ability to focus on major topics treated during the course and to report them with special attention to molecular aspects, i.e. basic signal transduction pathways and transcriptional regulation, and their possible biotechnological impact.
Course unit contents: Immunology (CFU 4) (Dr. A. Rosato)
Hypersensitivity reactions (type I-IV according to Gell and Coombs classification).
Transplantation immunology and transplant rejection.
Primary and secondary immunodeficiencies
Vaccination, vaccines and adjuvants
In vivo molecular imaging

General Pathology (CFU: 4) (Prof. L. Gorza)
Cellular adaptive responses: molecular aspects of hypertrophy and atrophy (Cardiac hypertrophy and heart failure. Mechanisms of skeletal muscle atrophy. Muscular dystrophies).

Cell death: divergent effects of the cell stress-response (cytoprotection after exposure to stressors and in cancer cells; increased apoptosis in atherosclerosis). Pharmacological intervention on cellular chaperones.

Quality control of protein folding: when and how to manipulate it. Protein misfolding diseases. Cystic fibrosis. Amyloidosis and Alzheimer’s disease.

Molecular pathology of diabetes and insulin resistance. Obesity and mechanisms of food intake regulation

Inflammation: how to interfere with inflammasomes and fibrosis.

Biomarkers in cancer.
Planned learning activities and teaching methods: Ex-cathedra lessons focussing on experimental evidence. Students in small groups will be invited to critically read a recent research paper on the topics of the course, to present it to and discuss it with the classroom (Journal Club).
Additional notes about suggested reading: Powerpoint files will be available. Some topics will be implemented by selected Reviews.
Textbooks (and optional supplementary readings)
  • Kumar, Abbas, Aster, Robbins and Cotran Pathological basis of diseases. --: Elsevier, 2015. IX Edizione Cerca nel catalogo
  • Abbas, Lichtman, Pillai, Immunologia cellulare e molecolare.. --: Elsevier, --. VII Edizione Cerca nel catalogo