First cycle
degree courses
Second cycle
degree courses
Single cycle
degree courses
School of Medicine
MEDICINE AND SURGERY
Course unit
IMMUNOLOGY
ME14103788, A.A. 2017/18

Information concerning the students who enrolled in A.Y. 2016/17

Information on the course unit
Degree course 6 years single cycle degree in
MEDICINE AND SURGERY (Ord. 2015)
ME1729, Degree course structure A.Y. 2015/16, A.Y. 2017/18
N0
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Number of ECTS credits allocated 6.0
Type of assessment Mark
Course unit English denomination IMMUNOLOGY
Department of reference Department of Medicine
Mandatory attendance
Language of instruction Italian
Branch PADOVA
Single Course unit The Course unit CANNOT be attended under the option Single Course unit attendance
Optional Course unit The Course unit is available ONLY for students enrolled in MEDICINE AND SURGERY (Ord. 2015)

Lecturers
Teacher in charge ANTONIO ROSATO MED/04
Other lecturers SUSANNA MANDRUZZATO MED/04
PAOLA ZANOVELLO MED/04

ECTS: details
Type Scientific-Disciplinary Sector Credits allocated
Educational activities in elective or integrative disciplines MED/04 General Pathology 6.0

Course unit organization
Period Second semester
Year 2nd Year
Teaching method frontal

Type of hours Credits Teaching
hours
Hours of
Individual study
Shifts
Group didactic activities 0.0 24 0.0 No turn
Lecture 6.0 48 102.0 No turn

Calendar
Start of activities 26/02/2018
End of activities 01/06/2018
Show course schedule 2019/20 Reg.2015 course timetable

Examination board
Board From To Members of the board
6 COMMISSIONE DI ESAME DI IMMUNOLOGIA A.A. 2018-2019 02/10/2018 31/12/2019 ROSATO ANTONIO (Presidente)
MANDRUZZATO SUSANNA (Membro Effettivo)
5 COMMISSIONE DI ESAME DI IMMUNOLOGIA A.A. 2017-2018 02/10/2017 30/12/2018 ROSATO ANTONIO (Presidente)
MANDRUZZATO SUSANNA (Membro Effettivo)
ZANOVELLO PAOLA (Membro Effettivo)
4 IMMUNOLOGIA - COMMISSIONE D' ESAME 2017/2018 02/10/2017 30/12/2018 ZANOVELLO PAOLA (Presidente)
AMADORI ALBERTO (Membro Effettivo)
3 IMMUNOLOGIA - COMMISSIONE D' ESAME 2016/2017 01/10/2016 30/12/2018 ZANOVELLO PAOLA (Presidente)
2 IMMUNOLOGIA - COMMISSIONE D' ESAME 2014/2015 01/10/2014 30/12/2018 ZANOVELLO PAOLA (Presidente)
AMADORI ALBERTO (Membro Effettivo)
MANDRUZZATO SUSANNA (Supplente)
1 IMMUNOLOGIA - COMMISSIONE D' ESAME 2013/2014 01/10/2013 30/12/2018 ZANOVELLO PAOLA (Presidente)
AMADORI ALBERTO (Membro Effettivo)
MANDRUZZATO SUSANNA (Supplente)

Syllabus
Prerequisites: A solid background in genetics, cellular biology, molecular biology, anatomy, and histology is strictly required.
Target skills and knowledge: This Course aims at transmitting to MD students all the fundamental notions on the mechanisms that regulate immune system functioning, with special attention to its ability to guarantee the organism’s homestasis against microbial microenvironment. Moreover, this Course will provide MD students with the basic notions about the alterations/dysfunctions that the above mechanisms could undergo to, in order to empower them with the necessary instruments to better understand during their future learning itinerary all the immuno-pathologic conditions that they will frequently encounter in clinical practice.
Examination methods: Multiple choice tests, possibly integrated by a subsequent interview
Assessment criteria: A questionnaire of about 90 multiple-choice questions will be administered at the end of the Course, covering exhaustively all the items forming the teaching core. The questions will be prepared to specifically verify the ability of the Students to connect the different compartments, components and elements of the immune response.
Course unit contents: The Course is articulated into two phases:
1) A first cycle of lessons where the fundamental components of the immune system will be described; this analytical description of the elements constituting the immune system will be followed by the effort to provide an integrated view of their functioning within the economy of the immune response:
2) A second cycle of lessons will be centered on the mechanisms underlying the different hypersensitivity reactions; in this setting, the clinical pictures deriving from each of them will be alluded.
Planned learning activities and teaching methods: IMMUNOLOGY:
•THE IMMUNE SYSTEM
GENERAL FEATURES
CELLS AND ORGANS
•INNATE IMMUNITY: CELLS, RECEPTORS, MEDIATORS
•THE MAJOR HISTOCOMPATIBILITY COMPLEX (MHC)
GENE ARRANGEMENT
STRUCTURE AND BIOLOGICAL PROPERTIES OF MHC MOLECULES
•ONTOGENESIS OF T AND B CELLS
•ACQUIRED IMMUNITY RECEPTORS: THE T CELL ANTIGEN RECEPTOR (TCR)
STRUCTURE
GENERATION OF TCR AND ANTIBODY DIVERSITY
•ANTIGEN RECOGNITION AND LYMPHOCYTE ACTVATION
ANTIGEN PROCESSING AND PRESENTATION TO T LYMPOCYTES
•ACQUIRED IMMUNITY RECEPTORS: THE ANTIBODIES (Ig)
STRUCTURE
EFFECTOR FUNCTIONS
•THE COMPLEMENT SYSTEM
ORGANIZATION AND ACTIVATION
BIOLOGICAL CONSEQuENCES
•EFFECTOR MECHANISMS OF IMMUNE REACTIONS (CTL, ADCC)
•EFFECTOR PHASES OF IMMUNE RESPONSES
CYTOKINES AND CHEMOKINES
COOPERATION BETWEEN T AND B LYMPHOCYTES
TH1/TH2 POLARIZATION OF T CELLS
HUMORAL RESPONSES
CELL-MEDIATED RESPONSES

IMMUNOPATHOLOGY:
•HYPERSENSITIVITY REACTIONS:
GENERAL FEATURES AND CLASSIFICATION ACCORDING TO GELL AND COOMBS
TYPE I, II, III AND IV HYPERSENSITIVITY
•TOLERANCE AND AUTOIMMUNITY
•TUMOR IMMUNOLOGY
•TRANSPLANTATION IMMUNOLOGY
ELEMENTS ON PRIMARY AND SECONDARY IMMUNODEFICIENCIES
Textbooks (and optional supplementary readings)
  • Janeway, Charles A.; Mowat, Allan; Walport, Mark; Murphy, Kenneth; Travers, Paul, Immunobiologia. Padova: Piccin, 2014. Cerca nel catalogo
  • Abbas, Abul K.; Lichtman, Andrew H.; Sozzani, Silvano; Baker, Alexandra; Baker, David L., Immunologia cellulare e molecolare. Milano: Elsevier, 2015. Cerca nel catalogo
  • Parham, Peter, Il sistema immunitario. Napoli: Edises, 2017. Cerca nel catalogo
  • Delves, PJ, Martin SJ, Burton DR, Roitt IM, Roitt's essential Immunology. Oxford: Wiley Blackwell, 2017. Cerca nel catalogo