First cycle
degree courses
Second cycle
degree courses
Single cycle
degree courses
School of Medicine
Course unit
FAO2043791, A.A. 2019/20

Information concerning the students who enrolled in A.Y. 2016/17

Information on the course unit
Degree course 5 years single cycle degree in
PHARMACY (Ord. 2009)
FA1732, Degree course structure A.Y. 2009/10, A.Y. 2019/20
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Number of ECTS credits allocated 8.0
Type of assessment Mark
Department of reference Department of Pharmaceutical and Pharmacological Sciences
E-Learning website
Mandatory attendance No
Language of instruction Italian
Single Course unit The Course unit can be attended under the option Single Course unit attendance
Optional Course unit The Course unit can be chosen as Optional Course unit

Teacher in charge NICOLA FERRI BIO/14

ECTS: details
Type Scientific-Disciplinary Sector Credits allocated
Core courses BIO/14 Pharmacology 8.0

Course unit organization
Period First semester
Year 4th Year
Teaching method frontal

Type of hours Credits Teaching
Hours of
Individual study
Lecture 8.0 64 136.0 No turn

Start of activities 30/09/2019
End of activities 18/01/2020
Show course schedule 2019/20 Reg.2018 course timetable

Examination board
Board From To Members of the board
7 Commissione a.a. 2019/20 02/12/2019 30/09/2020 FERRI NICOLA (Presidente)

Prerequisites: Knowledge of physiology, inorganic chemistry, organic chemistry, biochemistry and pathology.
Target skills and knowledge: The course deals with aspects of general pharmacology and pharmacognosy concerning the pharmacodynamics and pharmacokinetics of drugs in the human body.
Examination methods: the exam is written with three open questions, two of general pharmacology and one of pharmacognosy
Assessment criteria: The evaluation of the student's preparation will be based on the understanding of the topics, on the acquisition of concepts and on the ability to apply them independently, mainly about 1) pharmacodynamics and pharmacokinetics, 2) pharmacological properties and their use of active components of vegetable drugs.
Course unit contents: Drugs and medicinal plants for the treatment and prevention of human diseases.
Pharmacodynamics. Regulation of the receptor response. Agonists and antagonists. Quantitative evaluation of the agonist-receptor interaction. Affinity and activity. Concentration-response curves and dose-response curves. Pure, partial or inverse agonist. Competitive, not competitive, functional antagonism. Dose-response curves in a population: the histogram of the frequencies and the cumulative curve. DE50, DL50, therapeutic index, margin of safety, NNT, risk-benefit ratio, cost-benefit ratio.
Pharmacokinetics. Routes of administration. First-pass effect. Entero-hepatic recirculation. Distribution: apparent volume, plasma proteins. Capture and efflux transporters. Metabolism: phase I and II reactions, cytochrome P450, genetic polymorphisms, bioactivation reactions, induction and enzymatic inhibition. Renal and biliary eliminations. Clearance. Bioavailability and bioequivalence. Therapeutic interval. Half-life (T1/2). Pharmacokinetic models. Pharmacokinetics of monoclonal antibodies.
Variability in response to drugs: in the individual and in the population, predictable and non-predictable factors. Reporting of ADR. Drug development, from phase one to phase four.
Pharmacognosy. Study of the pharmacological properties of the active components and their use.
- Drugs with highly potent active constituents. Digitalis spp., Strophantus spp. Papaver somniferum. Atropa belladonna. Erythroxylum coca. Physostigma venenosum. Curare. Ipecac. Rauwolfia serpentina. Ephedra sinica. Claviceps purpurea. Cannabis sativa. Catharanthus roseus. Colchicum autumnale. Taxus spp. Podophyllum peltatum.
Drugs acting on:
- CNS. Piper methysticum, Valeriana officinalis, Matricaria recutita, Anthemisis nobilis, Melissa officinalis, Eschscholtzia californica, Humulus lupulus, Lavandula angustifolia, Passiflora incarnata, Hypericum perforatum, Crocus sativus, Ginkgo biloba, Salvia officinalis.
- CVS and metabolism. Crataegus laevigata, Salvia miltiorrhiza, Allium sativum, Olea europaea, Hamamelis virginiana, Aesculus hippocastanum, Ruscus aculeatus, Melilotus officinalis, Commiphora mukul (guggul gum), Cynara scolymus, Monascus purpureus, Trigonella foenum graecum, Silybum marianum, Cyamopsis tetragonolobus (guar gum) , Plantago psyllium, Citrus aurantium, Paullinia cupana, Garcinia cambogia, Fucus vesiculosus.
- GIS. Icelandic Cetraria, Althaea officinalis, Malva sylvestris, Linum usitatissimum, Acacia senegal, Astragalus gummifer, Gentiana lutea, Cinchona spp. Artemisia absinthium, Pimpinella anisum, Illicium verum, Foeniculum vulgare, Glycyrrhiza glabra, Fraxinus ornus, Rheum officinalis, Rhamnus spp, Cassia spp, Aloe spp, Ricinus communis (oil).
- Adaptogens and immunostimulants: Panax ginseng, Eleutherococcus senticosus, Uncaria tormentosa, Echinaceae spp.
Planned learning activities and teaching methods: The lessons are mainly based on frontal teaching with discussion on different topics.
Additional notes about suggested reading: Use the lecture notes and reference texts.
The teaching material in pdf of the lesson will be made available on the e-learning platform.
The use of databases such as pubMed and pubChem and the official AIFA and EMA websites is also suggested.
Textbooks (and optional supplementary readings)
  • Clementi, Francesco; Fumagalli, Guido; Chiamulera, Cristiano, Farmacologia generale e molecolareil meccanismo d'azione dei farmaciFrancesco Clementi, Guido Fumagallico-editors: Cristiano Chiamulera ... [et al.]. Milano: Edra, 2016. Cerca nel catalogo
  • Edwards, Sarah E., Phytopharmacyan evidence-based guide to herbal medicinal productsSarah E. Edwards ... [et al.]. Chichester [etc.]: Wiley Blackwell, 2015. Cerca nel catalogo
  • Capasso, Francesco; Izzo, Angelo A., Fitoterapiaimpiego razionale delle droghe vegetaliFrancesco Capasso, Giuliano Grandolini, Angelo A. Izzo. [Milano]: Springer, 2006. Cerca nel catalogo