First cycle
degree courses
Second cycle
degree courses
Single cycle
degree courses
School of Medicine
Course unit
FAM1027344, A.A. 2018/19

Information concerning the students who enrolled in A.Y. 2016/17

Information on the course unit
Degree course 5 years single cycle degree in
PHARMACY (Ord. 2009)
FA1732, Degree course structure A.Y. 2009/10, A.Y. 2018/19
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Number of ECTS credits allocated 10.0
Type of assessment Mark
Course unit English denomination PATHOLOGY AND PHYSIOPATHOLOGY
Department of reference Department of Pharmaceutical and Pharmacological Sciences
Mandatory attendance No
Language of instruction Italian
Single Course unit The Course unit can be attended under the option Single Course unit attendance
Optional Course unit The Course unit can be chosen as Optional Course unit

Teacher in charge POMPEO VOLPE MED/04

ECTS: details
Type Scientific-Disciplinary Sector Credits allocated
Basic courses MED/04 General Pathology 10.0

Course unit organization
Period First semester
Year 3rd Year
Teaching method frontal

Type of hours Credits Teaching
Hours of
Individual study
Lecture 10.0 80 170.0 No turn

Start of activities 01/10/2018
End of activities 18/01/2019
Show course schedule 2019/20 Reg.2018 course timetable

Examination board
Board From To Members of the board
7 Commissione a.a. 2019/20 02/12/2019 30/09/2020 VOLPE POMPEO (Presidente)
NORI ALESSANDRA (Membro Effettivo)
6 Commissione a.a. 2018/19 01/12/2018 30/09/2019 VOLPE POMPEO (Presidente)
NORI ALESSANDRA (Membro Effettivo)

Prerequisites: Knowledge of Anatomy, Physiology and Biochemistry
Target skills and knowledge: The educational goal of General pathology is to provide the graduate, who shall held their profession in connection with the distribution of medication, prevention and health education, knowledge essential for the understanding of the causes and pathogenetic mechanisms that underlie diseases. The educational objective of Pathophysiology is to integrate the elements characterizing the pathology with the fundamentals of general pathophysiology.
Examination methods: Hand-written examination made up of three general questions (open questions).
Assessment criteria: For each of the three questions maximum score is 10 points for a perfect answer. The score is 9 points for an optimanl answer, 8 for a good one, 7 for an ample and correct one, 6 for an adequate one, 5 for an inadequate one, 4 for one with mistakes, 3 for a partial one with mistakes, 2 for one with several mistakes, 1 for one that is paraphrase of the question, 0 for no answer.
It will be evaluated acquisition of fundamental knowledge for a given chapter of general pathology and of pathophysiology.
It will be evaluated appropriateness of biological and medical terminology.
Course unit contents: Etiology and pathogenesis. Causes of diseases; elementary and complex mechanisms of disease. From normal to pathological.
General pathophysiology. From physiology to decompensation. Compensatory mechanisms and failure.

General etiology. Definition of disease. Etiology and pathogenesis of pathological phenomena. Internal and external factors of the disease. Etiological multiplicity. (a) Pathogenic intrinsic factors. Mutagens and genetic mutations: molecular mechanisms and modalities, phenotypic expression of mutations. Hereditary transmission mode. Hereditary diseases and genetic disorders: informational errors, alterations of the expression of genetic information and of post-translational epigenesis. Diseases caused by chromosomal abnormalities. (b) Pathogenic extrinsic factors. Adverse drug reactions.

Cellular Pathology. Reversible and irreversible alterations of cellular structure and function. Adaptive responses of cells and intercellular environment. Cell death: necrosis and apoptosis. Changes in growth and differentiation: atrophy, hypertrophy, hyperplasia, metaplasia. Regeneration and repair.

Inflammation. Definition and cardinal signs. Acute inflammation. Cells and chemical mediators of acute inflammation. Chemotaxis and phagocytosis. Macrophages. Cytokines. Complement. Chronic inflammation. Foreign body granulomas and infectious granulomas. General effects of local lesion and inflammation.

Immunology and immunopathology. The immune system. Lymphocyte populations. Characteristics of the immune response: specificity and memory. Immunological tolerance. Antigens and antibodies. Major histocompatibility antigens and rejection of transplants. Immune deficiencies. Immunosuppression. Immediate-type and retarded hypersensitivity. Pathogenesis of autoimmune diseases.

Oncology. Nature of the tumors. Types of cancers. Properties of cancer cells. Etiology of cancer: chemical, physical and viral causes. Informational errors and carcinogenesis. Pathogenesis of neoplastic transformation. Oncogenes and anti-oncogenes. Tumor angiogenesis. Local invasiveness and metastasis.

Infectious diseases. Interactions between infecting agent and host: host defenses against infections, mechanisms of action of pathogenic microorganisms. Examples of pathogenesis of microbial and viral diseases.

Pathophysiology. Criteria and classification methods. Cardiac pathophysiology. Heart failure. Circulatory pathophysiology. Edema. Ischemia, infarction. Shock. Arteriosclerosis, atherosclerosis. Pathophysiology of blood. Anemias. Pathophysiology of hemostasis. Bleeding. Thrombosis. Respiratory physiopathology. Anoxia and hypercapnia. Renal pathophysiology. Acute and chronic failure. Liver pathophysiology. Insufficiency, jaundice and hyperbilirubinemias.

Pathophysiology of metabolism. Diabetes. Pathology of lipoproteins and hypercholesterolemia. Examples of inborn errors of metabolism and gene therapy. Pathophysiology of the endocrine system. Hormone resistance syndromes. Pathophysiology of thermoregulation: hyperthermia and fever. Pathophysiology of skeletal muscle. Muscular Dystrophies. Malignant Hyperthermia. Examples of disorders of ion channels.
Planned learning activities and teaching methods: Ex cathedra lectures. Thematic insights.
Additional notes about suggested reading: Ppt files of lectures made available to students at the begining of each academic year
Textbooks (and optional supplementary readings)
  • G.M. Pontieri., Elementi di Patologia generale e Fisiopatologia generale. Padova: Piccin, 2018. Cerca nel catalogo
  • Fabio Celotti, Patologia generale e Fisiopatologia. Napoli: Edises, 2013. Cerca nel catalogo

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