First cycle
degree courses
Second cycle
degree courses
Single cycle
degree courses
School of Medicine
PHARMACY
Course unit
MEDICINAL AND TOXICOLOGICAL CHEMISTRY PART 2
FA04101260, A.A. 2018/19

Information concerning the students who enrolled in A.Y. 2016/17

Information on the course unit
Degree course 5 years single cycle degree in
PHARMACY (Ord. 2009)
FA1732, Degree course structure A.Y. 2009/10, A.Y. 2018/19
N0
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Number of ECTS credits allocated 10.0
Type of assessment Mark
Course unit English denomination MEDICINAL AND TOXICOLOGICAL CHEMISTRY PART 2
Department of reference Department of Pharmaceutical and Pharmacological Sciences
E-Learning website https://elearning.unipd.it/dsf/course/view.php?idnumber=2018-FA1732-000ZZ-2016-FA04101260-N0
Mandatory attendance No
Language of instruction Italian
Branch PADOVA
Single Course unit The Course unit can be attended under the option Single Course unit attendance
Optional Course unit The Course unit can be chosen as Optional Course unit

Lecturers
Teacher in charge GIUSEPPE ZAGOTTO CHIM/08

ECTS: details
Type Scientific-Disciplinary Sector Credits allocated
Core courses CHIM/08 Pharmaceutical Chemistry 10.0

Course unit organization
Period First semester
Year 3rd Year
Teaching method frontal

Type of hours Credits Teaching
hours
Hours of
Individual study
Shifts
Lecture 10.0 80 170.0 No turn

Calendar
Start of activities 01/10/2018
End of activities 18/01/2019
Show course schedule 2019/20 Reg.2018 course timetable

Examination board
Board From To Members of the board
6 Commissione a.a. 2018/19 03/12/2018 30/09/2019 ZAGOTTO GIUSEPPE (Presidente)
CHILIN ADRIANA (Membro Effettivo)
MORO STEFANO (Membro Effettivo)

Syllabus
Prerequisites: Basic knowledge to this course are general chemistry (chemical bond, chemical equilibrium, chemical kinetic and some electrochemistry), organic chemistry (properties of the functional groups and of small organic molecules), biochemistry (aminoacids, proteins and nucleic acids), physiology (mainly CNS and nerve conduction/communication mechanisms) and pathology (mainly the inflammatory process)
Target skills and knowledge: The course deals with the chemical and physiologic properties of drugs used in the current clinical practice mainly as CNS agents, pain and inflammation relieving drugs, and hormones.
The student will learn the chemical properties (acidity/basicity, electrophilicity/nucleophilicity and Structure-Activity relationships), the biological properties (the details of the interaction with the receptor) and the therapeutic properties of the drugs.
Examination methods: The exam consists of a written and an oral part. The written part is made up of multiple choice questions and of two short open questions.
The oral exam is an interview on a couple of topics aimed at understanding the student's ability to discuss pharmaceutical chemistry and to link different aspects of drugs (e.g. chemical properties, physical properties, stability, absorption, distribution, metabolism and excretion).
Assessment criteria: The examination will valuate the knowledge and the ability to discuss the topics taught during the course.
The ability of the student to connect different parts of the course and to discuss the chemical properties of the drugs will be appreciated.
In detail the final examination will be made-up from a written test (to examine the whole learning o the course topics by the student and made of multiple choice questions plus two very short questions) and a oral test in which the student will discuss deeply a couple of drugs treated within the course.
Course unit contents: Introduction: properties of the drug-receptor interaction and examples, chemical-physical properties of the molecules and some recallings of physiology and biochemistry.
Cholinergic system drugs: muscarinic agonists, acetylcholinesterase inhibitors, muscarinic antagonists and nicotinic antagonists.
Drugs of the adrenergic system: direct α and β receptor agonists, indirect agonists, α and β receptor antagonists. Antiparkinson (direct and indirect dopaminergic agonists, central antimuscarinics).
Serotonergic system drugs.
Drugs of the purinergic system.
Sedative drugs of the CNS: sedatives and hypnotics (barbiturates, benzodiazepines, Z-drugs and melatonin), anticonvulsants (direct and indirect GABA agonists, blockers of the Na+ and Ca++ channel, other antiepileptics), antipsychotics (typical and atypical), anxiolytics.
CNS stimulant drugs: antidepressants.
Drugs and the histaminergic system: H1 antagonists. H2 antagonists, proton pump inhibitors.
General anesthetics.
Local anesthetics.
Narcotic analgesics.
Steroid hormones: corticosteroids (glucocorticoids, mineralocorticoids and anti-inflammatory steroids), androgens, estrogens, progestinics.
Thyroid hormones and drugs.
Homeostasis of calcium and drugs.
Non-steroidal anti-inflammatory drugs (NSAIDs).
Phosphodiesterase inhibitors and other medications for male conditions.
Drugs for the treatment of constipation and diarrhea
Planned learning activities and teaching methods: Classroom teaching. 10 CFU.
Additional notes about suggested reading: In addition the lessons in "Portable Document Format" (PDF) students will be provided with indications of databases or literature reports that can be useful for any further information or updates with respect to what they have been taught during the lesson.
Textbooks (and optional supplementary readings)
  • THOMAS L. LEMKE DAVID A. WILLIAMS FOYE, Foye’s Principi di Chimica Farmaceutica. Padova: Piccin, 2013. Ottimo testo Cerca nel catalogo
  • Francesco Clementi, Guido Fumagalli, Farmacologia generale e molecolare. --: UTET, 2012. E' un testo che permette un collegamento con il corso di farmacologia. Testo complementare. Cerca nel catalogo
  • Patrick, Graham L.; Costantino, Gabriele, Chimica farmaceutica Graham L. Patrick. Napoli: Edises, 2015. Testo molto utile Cerca nel catalogo
  • Foye - Lemke - Zito - Roche - Williams, Principi di chimica farmaceutica - L'essenziale. Padova: Piccin, 2017. Cerca nel catalogo

Innovative teaching methods: Teaching and learning strategies
  • Lecturing
  • Questioning