First cycle
degree courses
Second cycle
degree courses
Single cycle
degree courses
School of Medicine
Course unit
FAO2043709, A.A. 2018/19

Information concerning the students who enrolled in A.Y. 2015/16

Information on the course unit
Degree course 5 years single cycle degree in
FA1733, Degree course structure A.Y. 2009/10, A.Y. 2018/19
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Number of ECTS credits allocated 6.0
Type of assessment Mark
Course unit English denomination TOXICOLOGY
Department of reference Department of Pharmaceutical and Pharmacological Sciences
Mandatory attendance No
Language of instruction Italian
Single Course unit The Course unit can be attended under the option Single Course unit attendance
Optional Course unit The Course unit can be chosen as Optional Course unit


ECTS: details
Type Scientific-Disciplinary Sector Credits allocated
Core courses BIO/14 Pharmacology 6.0

Course unit organization
Period Second semester
Year 4th Year
Teaching method frontal

Type of hours Credits Teaching
Hours of
Individual study
Lecture 6.0 48 102.0 No turn

Start of activities 25/02/2019
End of activities 14/06/2019
Show course schedule 2019/20 Reg.2009 course timetable

Examination board
Board From To Members of the board
7 Commissione a.a. 2019/20 01/12/2019 30/07/2020 COLUCCI ROCCHINA LUCIA (Presidente)
GIRON MARIA CECILIA (Membro Effettivo)
6 Commissione a.a. 2018/19 01/12/2018 30/07/2019 COLUCCI ROCCHINA LUCIA (Presidente)
GIRON MARIA CECILIA (Membro Effettivo)

Prerequisites: Basic Knowledge of Anatomy, Physiology, Biochemistry, Pathology and Pharmacology
Target skills and knowledge: The student will be able to:
1) to focus the risk for exposure to drugs and xenobiotics toxic or potentially toxic.
2) to know the main mechanisms of cellular and organ toxicity.
3) to understand the impact of susceptibility factors included the genetic polymorphism
4) to know the general principles of “preclinical testing” with the aim to identify agent toxicity including drugs, and to define prevention and precautionary measures.
5) to know how to evaluate the drug risk/benefit ratio and problems related to their correct or improper use.
Examination methods: Written evaluations consisting of open-ended questions and multiple choice questions related to topics covered during the course.
Assessment criteria: Through the use of open-ended questions will be evaluated the ability of the student to expose in a concise but also relevant, general topics through the use of appropriate terminology, to organize a structured speech on a particular topic by referring to examples relevant to the question and to link with related topics. Multiple choice questions will allow you to evaluate the understanding of various topics covered in class.
Course unit contents: Principles of toxicocinetics. Risk factors and individual susceptibility. Evaluation and classification of toxicological risk. Labeling rules for xenobiotics. European Chemical Agency. Main international regulatory authorities on health and toxicological risk protection. Occupational toxicology and related risk. Health surveillance and biological indicators of exposure, effect, susceptibility. Parameters for defining the toxicity for single administration and for repeated administration of chemical agents: LD50, NOAEL, LOAEL. Exposure limits of toxic agents in food, water, air: ADI, TLV. Therapeutic index and margin of safety of drugs. Carcinogenesis. Genotoxic and epigenetic carcinogens. Methodological aspects for the study of tumor initiators and promoters. Reproductive toxicity. Toxicological relevance of biotransformations, induction and enzymatic inhibition and genetic polymorphisms. Cellular mechanisms of toxicity. Necrosis and apoptosis, oxidative stress. Proto-oncogens and tumor suppressor genes. DNA repair mechanisms. Ecotoxicology. Metals. Main organ toxicity from xenobiotics and drugs: pulmonary, cutaneous, hepatic, renal, cardiovascular. Endocrine disrupters.Toxicity of the immune system. CNS toxicity. Addiction, substances of abuse and doping. Analytical toxicology, poisonings, antidotes. Toxicology of biotechnological drugs. Pharmacovigilance concepts. Adverse drug reactions (ADR), Eudravigilance, clinical and observational studies, risk/benefit ratio.
Planned learning activities and teaching methods: Frontal classes on the main topics in the field of Toxicology will take place and seminar activities will be organized with references to subjects worth of particular interest for professional activity.
Additional notes about suggested reading: The course material will be made available on Moodle platform. For further information, during the course will be provided scientific publications and suggested links and databases accessible on the web.
Textbooks (and optional supplementary readings)
  • Casarett & Doull., ELEMENTI DI TOSSICOLOGIA. Rozzano (MI): Ambrosiana, 2013. Cerca nel catalogo
  • Galli, Corsini, Marinovich., TOSSICOLOGIA. Padova: PIccin, 2016. Cerca nel catalogo
  • Balduini, Costa., TOSSICOLOGIA generale e applicata ai farmaci. Milano: Edra, 2015. Cerca nel catalogo
  • Ghi., TOSSICOLOGIA Principi e applicazioni all'uso dei farmaci e dei prodotti della salute. Torino: Minerva Medica, 2009. Cerca nel catalogo

Innovative teaching methods: Teaching and learning strategies
  • Lecturing
  • Problem based learning
  • Case study
  • Working in group
  • Questioning
  • Story telling
  • Problem solving
  • Active quizzes for Concept Verification Tests and class discussions
  • Loading of files and pages (web pages, Moodle, ...)
  • Learning journal

Innovative teaching methods: Software or applications used
  • Moodle (files, quizzes, workshops, ...)

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