First cycle
degree courses
Second cycle
degree courses
Single cycle
degree courses
School of Medicine
PHARMACY
Course unit
TOXICOLOGICAL CHEMISTRY
MEP3051831, A.A. 2019/20

Information concerning the students who enrolled in A.Y. 2015/16

Information on the course unit
Degree course 5 years single cycle degree in
PHARMACY (Ord. 2009)
FA1732, Degree course structure A.Y. 2009/10, A.Y. 2019/20
N0
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Number of ECTS credits allocated 6.0
Type of assessment Mark
Course unit English denomination TOXICOLOGICAL CHEMISTRY
Department of reference Department of Pharmaceutical and Pharmacological Sciences
Mandatory attendance No
Language of instruction Italian
Branch PADOVA
Single Course unit The Course unit can be attended under the option Single Course unit attendance
Optional Course unit The Course unit can be chosen as Optional Course unit

Lecturers
Teacher in charge CRISTINA MARZANO CHIM/08

ECTS: details
Type Scientific-Disciplinary Sector Credits allocated
Core courses CHIM/08 Pharmaceutical Chemistry 6.0

Course unit organization
Period First semester
Year 5th Year
Teaching method frontal

Type of hours Credits Teaching
hours
Hours of
Individual study
Shifts
Lecture 6.0 48 102.0 No turn

Calendar
Start of activities 30/09/2019
End of activities 18/01/2020
Show course schedule 2019/20 Reg.2018 course timetable

Syllabus
Prerequisites: Basic knowledge in General, Inorganic and Organic Chemistry and in Biochemistry.
Target skills and knowledge: The course deals with the chemistry of toxic substances with emphasis on their interactions with biological tissue and living systems. At the end of the course, students have the knowledge, skills and abilities required to relate the chemical structure and physical characteristics of various chemicals, mainly environmental and occupational xenobiotics to their toxic effects.
Examination methods: The final exam consists of a written test (1.5 hrs long) covering the entire course program and composed of 2 open questions (0-6 points for each question) and 18 multiple-choice questions (total 0-18 points.
Assessment criteria: The assessment of learning will be done through the evaluation of the comprehension of the addressed topics and on the bases of the concepts and methodologies learnt during the class session. In particular, the acquisition of chemical-toxicological knowledge and skills concerning the main classes of xenobiotics will be evaluated.
Course unit contents: The course bridges the gap between toxicology and chemistry, emphasizing chemical aspects of toxicological phenomena, including fates and effects of xenobiotic chemicals in living systems.
The course consists of a General Part and of a Specific Part.
The General Part deals with the general principles necessary to understand and characterize a toxic effect; it examines the direct relationship between the chemical-physical properties of a chemical agent and its toxicological potential.
Introduction to Toxicological Chemistry. General toxicology principles functional to the course of toxicological chemistry. Classification of toxic substances. Biotransformation (bioactivation and detoxification) of xenobiotics. Chemical bases of mutagenic, carcinogenic and teratogenic effects.
Control of exposure to toxic substances. Risk estimation. Primary and secondary prevention, use of biomarkers as diagnostic and prognostic tools for environmental health.
The Special Part is devoted to the toxicological chemistry of various xenobiotics organized according to their chemical class. These are both natural and synthetic molecules, present in various environmental and food matrices. Particular attention is paid to emerging chemical contaminants, including endocrine disruptors.
For each class of xenobiotics are described: i) the chemical-physical properties; ii) the uses and sources of exposure; iii) the toxicokinetic properties, iv) the toxicodynamic properties, with particular emphasis on the most recent scientific findings concerning the molecular mechanisms underlying toxic effects.
Planned learning activities and teaching methods: Lectures supported by PowerPoint slides. Seminars relating to specific subjects will also be carried out.
Additional notes about suggested reading: Lecture notes. A course textbook written by the teacher is available.
Textbooks (and optional supplementary readings)
  • C.Marzano-C.Medana, Chimica Tossicologica. --: Ed. Piccin, Padova, 2018. Cerca nel catalogo

Innovative teaching methods: Teaching and learning strategies
  • Lecturing
  • Interactive lecturing
  • Questioning

Innovative teaching methods: Software or applications used
  • Moodle (files, quizzes, workshops, ...)

Sustainable Development Goals (SDGs)
Good Health and Well-Being Quality Education Gender Equality Clean Water and Sanitation Climate Action