First cycle
degree courses
Second cycle
degree courses
Single cycle
degree courses
School of Medicine
PHARMACY
Course unit
PHARMACOGENETIC AND PHARMACOGENOMIC
MEP3051891, A.A. 2018/19

Information concerning the students who enrolled in A.Y. 2014/15

Information on the course unit
Degree course 5 years single cycle degree in
PHARMACY (Ord. 2009)
FA1732, Degree course structure A.Y. 2009/10, A.Y. 2018/19
N0
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Number of ECTS credits allocated 6.0
Type of assessment Mark
Course unit English denomination PHARMACOGENETIC AND PHARMACOGENOMIC
Department of reference Department of Pharmaceutical and Pharmacological Sciences
E-Learning website https://elearning.unipd.it/dsf/course/view.php?idnumber=2018-FA1732-000ZZ-2014-MEP3051891-N0
Mandatory attendance
Language of instruction Italian
Branch PADOVA
Single Course unit The Course unit can be attended under the option Single Course unit attendance
Optional Course unit The Course unit can be chosen as Optional Course unit

Lecturers
Teacher in charge CHIARA BOLEGO BIO/14

ECTS: details
Type Scientific-Disciplinary Sector Credits allocated
Core courses BIO/14 Pharmacology 6.0

Course unit organization
Period First semester
Year 5th Year
Teaching method frontal

Type of hours Credits Teaching
hours
Hours of
Individual study
Shifts
Lecture 6.0 48 102.0 No turn

Calendar
Start of activities 01/10/2018
End of activities 18/01/2019
Show course schedule 2019/20 Reg.2018 course timetable

Examination board
Board From To Members of the board
6 Commissione a.a. 2018/19 03/12/2018 30/09/2019 BOLEGO CHIARA (Presidente)
FERRI NICOLA (Membro Effettivo)
TRENTI ANNALISA (Supplente)

Syllabus
Prerequisites: Sound principles of Pharmacology and Pharmacotherapy as well as knowledge of cellular and molecular biology are required.
Target skills and knowledge: Students will acquire advanced knowledge in personalized therapies. Particular attention will be paid to analyze how the genetic background (genes codifying for enzymes of drug metabolism and and drug targets) affects the clinical responses to currently used drugs. Other factors influencing drug resposnes including combined therapies, age and environmental factors will also be discussed. The final goal will be to identify specific biomarkers and pharmacogenetic tests helpful to personalize the clinical use of drugs.
The course will also provide information on new drug targets identified starting from pharmacogenomics.
Examination methods: Written test including both multiple choice (each correct answer +1 point; each wrong answer -0.5) and open questions. Total: 33 points (30/30 cum laude).
Students will be given the opportunity to create a PowerPoint presentation and discuss recent papers related to the subject.
Assessment criteria: Critical understanding of principles of pharmacogenetics and pharmacogenomics applied to personalized therapies will be assessed.In particular students will be asked to translate the acquired knowledge on specific gene polymorfisms/mutation to the clinical use of drugs belonging to different therapeutic classes.
Course unit contents: Factors affecting drug responses: intrinsic (genetic background, age, race) and extrinsic factors (drug-drug interactions,concurrent pathological conditions)
Genetics: functional effects of specific small- and large-scale mutations; monogenic and polygenic traits; population genetics
Methods in pharmacogenetics and pharmacogenomics (phenotyping, genotyping, GWAs, NGS)
Examples of genetic variations in drug efficacy and toxicity
Clinical implications of pharmacogenetics: identification of biomarkers for genetic tests
Pharmacogenomics for drug discovery: target therapies in the setting of tumors and genetic diseases
Pharmacogenetics and pharmacogenomics in clinical trials
Principles of epigenetics
Planned learning activities and teaching methods: Lectures and discussion based on updated review
articles.
Active-quiz.
Additional notes about suggested reading: Books on the topic are not currently available for students.

Being the subject changing quickly, students are invited to read updated papers provided by the teacher.
Textbooks (and optional supplementary readings)

Innovative teaching methods: Teaching and learning strategies
  • Lecturing
  • Active quizzes for Concept Verification Tests and class discussions
  • Loading of files and pages (web pages, Moodle, ...)
  • Learning journal

Innovative teaching methods: Software or applications used
  • Moodle (files, quizzes, workshops, ...)

Sustainable Development Goals (SDGs)
Good Health and Well-Being Quality Education